Obstetric complications and clinical presentation in first episode of psychosis

Objective:Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disord...

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Autores: Verdolini, N, Mezquida, G, Valli, I, Garcia-Rizo, C, Cuesta, M, Vieta, E, Bioque, M, Lobo, A, Gonzalez-Pinto, A, Pina-Camacho, L, Corripio, I, Garriga, M, Baeza, I, Martinez-Sadurni, L, Bitanihirwe, B, Cannon, M, Bernardo, M
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p16140
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16140
Access Level:acceso abierto
Palavra-chave:First-episode psychosis
obstetric complications
delivery
psychopathology
epiphenomena
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spelling Obstetric complications and clinical presentation in first episode of psychosisVerdolini, NMezquida, GValli, IGarcia-Rizo, CCuesta, MVieta, EBioque, MLobo, AGonzalez-Pinto, APina-Camacho, LCorripio, IGarriga, MBaeza, IMartinez-Sadurni, LBitanihirwe, BCannon, MBernardo, MFirst-episode psychosisobstetric complicationsdeliverypsychopathologyepiphenomenaObjective:Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods:Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results:Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions:Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.CAMBRIDGE UNIV PRESS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16140ACTA NEUROPSYCHIATRICAISSN: 16015215reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p161402026-06-14T12:41:47Z
dc.title.none.fl_str_mv Obstetric complications and clinical presentation in first episode of psychosis
title Obstetric complications and clinical presentation in first episode of psychosis
spellingShingle Obstetric complications and clinical presentation in first episode of psychosis
Verdolini, N
First-episode psychosis
obstetric complications
delivery
psychopathology
epiphenomena
title_short Obstetric complications and clinical presentation in first episode of psychosis
title_full Obstetric complications and clinical presentation in first episode of psychosis
title_fullStr Obstetric complications and clinical presentation in first episode of psychosis
title_full_unstemmed Obstetric complications and clinical presentation in first episode of psychosis
title_sort Obstetric complications and clinical presentation in first episode of psychosis
dc.creator.none.fl_str_mv Verdolini, N
Mezquida, G
Valli, I
Garcia-Rizo, C
Cuesta, M
Vieta, E
Bioque, M
Lobo, A
Gonzalez-Pinto, A
Pina-Camacho, L
Corripio, I
Garriga, M
Baeza, I
Martinez-Sadurni, L
Bitanihirwe, B
Cannon, M
Bernardo, M
author Verdolini, N
author_facet Verdolini, N
Mezquida, G
Valli, I
Garcia-Rizo, C
Cuesta, M
Vieta, E
Bioque, M
Lobo, A
Gonzalez-Pinto, A
Pina-Camacho, L
Corripio, I
Garriga, M
Baeza, I
Martinez-Sadurni, L
Bitanihirwe, B
Cannon, M
Bernardo, M
author_role author
author2 Mezquida, G
Valli, I
Garcia-Rizo, C
Cuesta, M
Vieta, E
Bioque, M
Lobo, A
Gonzalez-Pinto, A
Pina-Camacho, L
Corripio, I
Garriga, M
Baeza, I
Martinez-Sadurni, L
Bitanihirwe, B
Cannon, M
Bernardo, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv First-episode psychosis
obstetric complications
delivery
psychopathology
epiphenomena
topic First-episode psychosis
obstetric complications
delivery
psychopathology
epiphenomena
description Objective:Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods:Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results:Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions:Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16140
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16140
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv ACTA NEUROPSYCHIATRICA
ISSN: 16015215
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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