Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55...

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Detalles Bibliográficos
Autores: Moreno Guillén, Estefanía, Andradas, Clara, Medrano Moya, Mireia, Caffarel, María M., Pérez-Gómez, Eduardo, Blasco-Benito, Sandra, Gómez-Cañas, María, Pazos, M. Ruth, Irving, Andrew J., Lluís i Biset, Carme, Canela Campos, Enric I. (Enric Isidre), 1949-, Fernández-Ruiz, Javier, Guzmán, Manuel, McCormick, Peter J., Sánchez Mora, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/122587
Acceso en línea:https://hdl.handle.net/2445/122587
Access Level:acceso abierto
Palabra clave:Transducció de senyal cel·lular
Càncer
Cellular signal transduction
Cancer
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spelling Targeting CB2-GPR55 receptor heteromers modulates cancer cell signalingMoreno Guillén, EstefaníaAndradas, ClaraMedrano Moya, MireiaCaffarel, María M.Pérez-Gómez, EduardoBlasco-Benito, SandraGómez-Cañas, MaríaPazos, M. RuthIrving, Andrew J.Lluís i Biset, CarmeCanela Campos, Enric I. (Enric Isidre), 1949-Fernández-Ruiz, JavierGuzmán, ManuelMcCormick, Peter J.Sánchez Mora, CristinaTransducció de senyal cel·lularCàncerCellular signal transductionCancerThe G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.American Society for Biochemistry and Molecular Biology2018201820142018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/122587Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1074/jbc.M114.561761Journal of Biological Chemistry, 2014, vol. 289, num. 32, p. 21960-21972https://doi.org/10.1074/jbc.M114.561761(c) American Society for Biochemistry and Molecular Biology, 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1225872026-05-29T05:05:01Z
dc.title.none.fl_str_mv Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
spellingShingle Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
Moreno Guillén, Estefanía
Transducció de senyal cel·lular
Càncer
Cellular signal transduction
Cancer
title_short Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_full Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_fullStr Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_full_unstemmed Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_sort Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
dc.creator.none.fl_str_mv Moreno Guillén, Estefanía
Andradas, Clara
Medrano Moya, Mireia
Caffarel, María M.
Pérez-Gómez, Eduardo
Blasco-Benito, Sandra
Gómez-Cañas, María
Pazos, M. Ruth
Irving, Andrew J.
Lluís i Biset, Carme
Canela Campos, Enric I. (Enric Isidre), 1949-
Fernández-Ruiz, Javier
Guzmán, Manuel
McCormick, Peter J.
Sánchez Mora, Cristina
author Moreno Guillén, Estefanía
author_facet Moreno Guillén, Estefanía
Andradas, Clara
Medrano Moya, Mireia
Caffarel, María M.
Pérez-Gómez, Eduardo
Blasco-Benito, Sandra
Gómez-Cañas, María
Pazos, M. Ruth
Irving, Andrew J.
Lluís i Biset, Carme
Canela Campos, Enric I. (Enric Isidre), 1949-
Fernández-Ruiz, Javier
Guzmán, Manuel
McCormick, Peter J.
Sánchez Mora, Cristina
author_role author
author2 Andradas, Clara
Medrano Moya, Mireia
Caffarel, María M.
Pérez-Gómez, Eduardo
Blasco-Benito, Sandra
Gómez-Cañas, María
Pazos, M. Ruth
Irving, Andrew J.
Lluís i Biset, Carme
Canela Campos, Enric I. (Enric Isidre), 1949-
Fernández-Ruiz, Javier
Guzmán, Manuel
McCormick, Peter J.
Sánchez Mora, Cristina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Transducció de senyal cel·lular
Càncer
Cellular signal transduction
Cancer
topic Transducció de senyal cel·lular
Càncer
Cellular signal transduction
Cancer
description The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
publishDate 2014
dc.date.none.fl_str_mv 2014
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/122587
url https://hdl.handle.net/2445/122587
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1074/jbc.M114.561761
Journal of Biological Chemistry, 2014, vol. 289, num. 32, p. 21960-21972
https://doi.org/10.1074/jbc.M114.561761
dc.rights.none.fl_str_mv (c) American Society for Biochemistry and Molecular Biology, 2014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Society for Biochemistry and Molecular Biology, 2014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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