Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies

The presence of monosomal karyotype (MK+) in acute myeloid leukemia (AML) is associated with dismal outcomes. We evaluated the impact of MK+ in AML (MK+AML, n = 240) and in myelodysplastic syndrome (MDS) (MK+MDS, n = 221) on hematopoietic cell transplantation outcomes compared with other cytogenetic...

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Detalles Bibliográficos
Autores: Pasquini, Marcelo|||0000-0003-1579-2293, Zhang, Mei-Jie, Medeiros, Bruno|||0000-0001-6972-8137, Armand, Philippe, Hu, Zhen-Huan, Nishihori, Taiga|||0000-0002-2621-7924, Aljurf, Mahmoud D., Akpek, Görgün, Cahn, Jean-Yves, Cairo, Mitchell S., Cerny, Jan|||0000-0002-6602-5505, Copelan, Edward A., Deol, Abhinav, Freytes, Cesar|||0000-0003-2880-6797, Gale, Robert Peter|||0000-0002-9156-1676, Ganguly, Siddhartha, George, Biju|||0000-0002-9847-9501, Gupta, Vikas|||0000-0002-1419-8607, Hale, Gregory A., Kamble, Rammurti T., Klumpp, Thomas R., Lazarus, Hillard M.|||0000-0002-1159-5607, Luger, Selina M., Liesveld, Jane L., Litzow, Mark|||0000-0002-9816-6302, Marks, David I., Martino Bofarull, Rodrigo|||0000-0001-5143-4042, Norkin, Maxim, Olsson, Richard|||0000-0001-5970-2128, Oran, Betul, Pawarode, Attaphol, Pulsipher, Michael A., Ramanathan, Muthalagu, Reshef, Ran, Saad, Ayman A., Saber, Wael, Savani, Bipin|||0000-0002-3304-9965, Schouten, Harry C., Ringden, Olle|||0000-0002-6092-1536, Tallman, Martin S., Uy, Geoffrey L., Wood, William A., Wirk, Baldeep Mona, Pérez, Waleska S., Batiwalla, Minoo, Weisdorf, Daniel J.
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289623
Acceso en línea:https://ddd.uab.cat/record/289623
https://dx.doi.org/urn:doi:10.1016/j.bbmt.2015.08.024
Access Level:acceso abierto
Palabra clave:Acute myeloid leukemia
Allogeneic transplantation
Monosomal karyotype
Myelodysplastic syndrome
Descripción
Sumario:The presence of monosomal karyotype (MK+) in acute myeloid leukemia (AML) is associated with dismal outcomes. We evaluated the impact of MK+ in AML (MK+AML, n = 240) and in myelodysplastic syndrome (MDS) (MK+MDS, n = 221) on hematopoietic cell transplantation outcomes compared with other cytogenetically defined groups (AML, n = 3360; MDS, n = 1373) as reported to the Center for International Blood and Marrow Transplant Research from 1998 to 2011. MK+ AML was associated with higher disease relapse (hazard ratio, 1.98; P <.01), similar transplantation-related mortality (TRM) (hazard ratio, 1.01; P =90), and worse survival (hazard ratio, 1.67; P <.01) compared with those outcomes for other cytogenetically defined AML. Among patients with MDS, MK+ MDS was associated with higher disease relapse (hazard ratio, 2.39; P <.01), higher TRM (hazard ratio, 1.80; P <.01), and worse survival (HR, 2.02; P <.01). Subset analyses comparing chromosome 7 abnormalities (del7/7q) with or without MK+ demonstrated higher mortality for MK+ disease in for both AML (hazard ratio, 1.72; P <.01) and MDS (hazard ratio, 1.79; P <.01). The strong negative impact of MK+ in myeloid malignancies was observed in all age groups and using either myeloablative or reduced-intensity conditioning regimens. Alternative approaches to mitigate disease relapse in this population are needed.

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