Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology

Introduction. Congenital glioblastoma multiforme represents only 3% of congenital central nervous system tumours and an infratentorial location is unusual. Case report. A newborn with congenital glioblastoma multiforme with no mutation in the TP53 gene or p53 nuclear immunoreactivity that infiltrate...

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Autores: Salas S, Agut T, Rovira C, Canizo D, Lavarino C, García-Alix A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p10228
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10228
Access Level:acceso abierto
Palabra clave:Brain tumor
Congenital tumor
Glioblastoma multiforme
Infant
p53
TP53 gene
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spelling Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biologySalas SAgut TRovira CCanizo DLavarino CGarcía-Alix ABrain tumorCongenital tumorGlioblastoma multiformeInfantp53TP53 geneIntroduction. Congenital glioblastoma multiforme represents only 3% of congenital central nervous system tumours and an infratentorial location is unusual. Case report. A newborn with congenital glioblastoma multiforme with no mutation in the TP53 gene or p53 nuclear immunoreactivity that infiltrated practically the whole brainstem and also invaded supratentorial structures. Conclusions. As far as we know, only four cases with an infratentorial location have been reported previously, three in the cerebellum and one in the brainstem. The biology of congenital glioblastoma multiforme is not well known and, unlike glioblastoma multiforme in adults and children, mutations in the TP53 gene are uncommon. However, this is not associated with a more favourable prognosis. These observations suggest that specific biological processes underlie fetal glioblastoma multiforme development.IMR PRESS2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10228REVISTA DE NEUROLOGIAISSN: 02100010ISSNe: 15766578reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuEspañolinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p102282026-05-27T12:37:41Z
dc.title.none.fl_str_mv Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
title Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
spellingShingle Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
Salas S
Brain tumor
Congenital tumor
Glioblastoma multiforme
Infant
p53
TP53 gene
title_short Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
title_full Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
title_fullStr Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
title_full_unstemmed Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
title_sort Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
dc.creator.none.fl_str_mv Salas S
Agut T
Rovira C
Canizo D
Lavarino C
García-Alix A
author Salas S
author_facet Salas S
Agut T
Rovira C
Canizo D
Lavarino C
García-Alix A
author_role author
author2 Agut T
Rovira C
Canizo D
Lavarino C
García-Alix A
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Brain tumor
Congenital tumor
Glioblastoma multiforme
Infant
p53
TP53 gene
topic Brain tumor
Congenital tumor
Glioblastoma multiforme
Infant
p53
TP53 gene
description Introduction. Congenital glioblastoma multiforme represents only 3% of congenital central nervous system tumours and an infratentorial location is unusual. Case report. A newborn with congenital glioblastoma multiforme with no mutation in the TP53 gene or p53 nuclear immunoreactivity that infiltrated practically the whole brainstem and also invaded supratentorial structures. Conclusions. As far as we know, only four cases with an infratentorial location have been reported previously, three in the cerebellum and one in the brainstem. The biology of congenital glioblastoma multiforme is not well known and, unlike glioblastoma multiforme in adults and children, mutations in the TP53 gene are uncommon. However, this is not associated with a more favourable prognosis. These observations suggest that specific biological processes underlie fetal glioblastoma multiforme development.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10228
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10228
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv IMR PRESS
publisher.none.fl_str_mv IMR PRESS
dc.source.none.fl_str_mv REVISTA DE NEUROLOGIA
ISSN: 02100010
ISSNe: 15766578
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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