Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits

[EN] Background Livestock populations are under constant selective pressure for higher productivity levels for different selective purposes. This pressure results in the selection of animals with unique adaptive and production traits. The study of genomic regions associated with these unique charact...

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Detalhes bibliográficos
Autores: Souza Fonseca, Pablo Augusto de, Suárez Vega, Aroa, Arranz Santos, Juan José, Gutiérrez Gil, Beatriz
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/23924
Acesso em linha:https://gsejournal.biomedcentral.com/articles/10.1186/s12711-024-00910-w#auth-Juan_J_-Arranz-Aff1
https://hdl.handle.net/10612/23924
Access Level:acceso abierto
Palavra-chave:Genética
Selective sweeps
Adaptation
Production
Sheep
3109.02 Genética
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spelling Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traitsSouza Fonseca, Pablo Augusto deSuárez Vega, AroaArranz Santos, Juan JoséGutiérrez Gil, BeatrizGenéticaSelective sweepsAdaptationProductionSheep3109.02 Genética[EN] Background Livestock populations are under constant selective pressure for higher productivity levels for different selective purposes. This pressure results in the selection of animals with unique adaptive and production traits. The study of genomic regions associated with these unique characteristics has the potential to improve biological knowledge regarding the adaptive process and how it is connected to production levels and resilience, which is the ability of an animal to adapt to stress or an imbalance in homeostasis. Sheep is a species that has been subjected to several natural and artificial selective pressures during its history, resulting in a highly specialized species for production and adaptation to challenging environments. Here, the data from multiple studies that aim at mapping selective sweeps across the sheep genome associated with production and adaptation traits were integrated to identify confirmed selective sweeps (CSS). Results In total, 37 studies were used to identify 518 CSS across the sheep genome, which were classified as production (147 prodCSS) and adaptation (219 adapCSS) CSS based on the frequency of each type of associated study. The genes within the CSS were associated with relevant biological processes for adaptation and production. For example, for adapCSS, the associated genes were related to the control of seasonality, circadian rhythm, and thermoregulation. On the other hand, genes associated with prodCSS were related to the control of feeding behaviour, reproduction, and cellular differentiation. In addition, genes harbouring both prodCSS and adapCSS showed an interesting association with lipid metabolism, suggesting a potential role of this process in the regulation of pleiotropic effects between these classes of traits. Conclusions The findings of this study contribute to a deeper understanding of the genetic link between productivity and adaptability in sheep breeds. This information may provide insights into the genetic mechanisms that underlie undesirable genetic correlations between these two groups of traits and pave the way for a better understanding of resilience as a positive ability to respond to environmental stressors, where the negative effects on production level are minimized.SISpringerGeneticaFacultad de Veterinaria2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://gsejournal.biomedcentral.com/articles/10.1186/s12711-024-00910-w#auth-Juan_J_-Arranz-Aff1https://hdl.handle.net/10612/23924reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónInglésinfo:eu-repo/grantAgreement/AEI/ Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia / PID2022-138676OB-100 http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/239242026-06-24T12:43:27Z
dc.title.none.fl_str_mv Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
title Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
spellingShingle Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
Souza Fonseca, Pablo Augusto de
Genética
Selective sweeps
Adaptation
Production
Sheep
3109.02 Genética
title_short Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
title_full Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
title_fullStr Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
title_full_unstemmed Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
title_sort Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits
dc.creator.none.fl_str_mv Souza Fonseca, Pablo Augusto de
Suárez Vega, Aroa
Arranz Santos, Juan José
Gutiérrez Gil, Beatriz
author Souza Fonseca, Pablo Augusto de
author_facet Souza Fonseca, Pablo Augusto de
Suárez Vega, Aroa
Arranz Santos, Juan José
Gutiérrez Gil, Beatriz
author_role author
author2 Suárez Vega, Aroa
Arranz Santos, Juan José
Gutiérrez Gil, Beatriz
author2_role author
author
author
dc.contributor.none.fl_str_mv Genetica
Facultad de Veterinaria
dc.subject.none.fl_str_mv Genética
Selective sweeps
Adaptation
Production
Sheep
3109.02 Genética
topic Genética
Selective sweeps
Adaptation
Production
Sheep
3109.02 Genética
description [EN] Background Livestock populations are under constant selective pressure for higher productivity levels for different selective purposes. This pressure results in the selection of animals with unique adaptive and production traits. The study of genomic regions associated with these unique characteristics has the potential to improve biological knowledge regarding the adaptive process and how it is connected to production levels and resilience, which is the ability of an animal to adapt to stress or an imbalance in homeostasis. Sheep is a species that has been subjected to several natural and artificial selective pressures during its history, resulting in a highly specialized species for production and adaptation to challenging environments. Here, the data from multiple studies that aim at mapping selective sweeps across the sheep genome associated with production and adaptation traits were integrated to identify confirmed selective sweeps (CSS). Results In total, 37 studies were used to identify 518 CSS across the sheep genome, which were classified as production (147 prodCSS) and adaptation (219 adapCSS) CSS based on the frequency of each type of associated study. The genes within the CSS were associated with relevant biological processes for adaptation and production. For example, for adapCSS, the associated genes were related to the control of seasonality, circadian rhythm, and thermoregulation. On the other hand, genes associated with prodCSS were related to the control of feeding behaviour, reproduction, and cellular differentiation. In addition, genes harbouring both prodCSS and adapCSS showed an interesting association with lipid metabolism, suggesting a potential role of this process in the regulation of pleiotropic effects between these classes of traits. Conclusions The findings of this study contribute to a deeper understanding of the genetic link between productivity and adaptability in sheep breeds. This information may provide insights into the genetic mechanisms that underlie undesirable genetic correlations between these two groups of traits and pave the way for a better understanding of resilience as a positive ability to respond to environmental stressors, where the negative effects on production level are minimized.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://gsejournal.biomedcentral.com/articles/10.1186/s12711-024-00910-w#auth-Juan_J_-Arranz-Aff1
https://hdl.handle.net/10612/23924
url https://gsejournal.biomedcentral.com/articles/10.1186/s12711-024-00910-w#auth-Juan_J_-Arranz-Aff1
https://hdl.handle.net/10612/23924
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/ Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia / PID2022-138676OB-100
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad de León
instname_str Universidad de León
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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