The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.

We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmiss...

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Autores: Brotons, Pedro, Jordán García, Iolanda, Bassat Orellana, Quique, Henares, Desiree, Fernández de Sevilla Estrach, Mariona, Ajanovic, Sara, Redin, A., Fumadó, Victoria, Baro, Bàrbara, Claverol, Joana, Varo, Rosauro, Cuadras, Daniel, Hecht, Jochen, Barrabeig i Fabregat, Irene, García García, Juan José, Launes Montaña, Cristian, Muñoz-Almagro, Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183875
Acceso en línea:https://hdl.handle.net/2445/183875
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Enterovirus
Llar
Enteroviruses
Éssers humans
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spelling The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.Brotons, PedroJordán García, IolandaBassat Orellana, QuiqueHenares, DesireeFernández de Sevilla Estrach, MarionaAjanovic, SaraRedin, A.Fumadó, VictoriaBaro, BàrbaraClaverol, JoanaVaro, RosauroCuadras, DanielHecht, JochenBarrabeig i Fabregat, IreneGarcía García, Juan JoséLaunes Montaña, CristianMuñoz-Almagro, CarmenSARS-CoV-2EnterovirusLlarSARS-CoV-2EnterovirusesÉssers humansWe aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183875Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/v13081598Viruses, 2021, vol. 13, num. 8, p. 1598https://doi.org/10.3390/v13081598cc-by (c) Brotons, Pedro et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1838752026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
title The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
spellingShingle The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
Brotons, Pedro
SARS-CoV-2
Enterovirus
Llar
SARS-CoV-2
Enteroviruses
Éssers humans
title_short The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
title_full The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
title_fullStr The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
title_full_unstemmed The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
title_sort The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
dc.creator.none.fl_str_mv Brotons, Pedro
Jordán García, Iolanda
Bassat Orellana, Quique
Henares, Desiree
Fernández de Sevilla Estrach, Mariona
Ajanovic, Sara
Redin, A.
Fumadó, Victoria
Baro, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig i Fabregat, Irene
García García, Juan José
Launes Montaña, Cristian
Muñoz-Almagro, Carmen
author Brotons, Pedro
author_facet Brotons, Pedro
Jordán García, Iolanda
Bassat Orellana, Quique
Henares, Desiree
Fernández de Sevilla Estrach, Mariona
Ajanovic, Sara
Redin, A.
Fumadó, Victoria
Baro, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig i Fabregat, Irene
García García, Juan José
Launes Montaña, Cristian
Muñoz-Almagro, Carmen
author_role author
author2 Jordán García, Iolanda
Bassat Orellana, Quique
Henares, Desiree
Fernández de Sevilla Estrach, Mariona
Ajanovic, Sara
Redin, A.
Fumadó, Victoria
Baro, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig i Fabregat, Irene
García García, Juan José
Launes Montaña, Cristian
Muñoz-Almagro, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Enterovirus
Llar
SARS-CoV-2
Enteroviruses
Éssers humans
topic SARS-CoV-2
Enterovirus
Llar
SARS-CoV-2
Enteroviruses
Éssers humans
description We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183875
url https://hdl.handle.net/2445/183875
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/v13081598
Viruses, 2021, vol. 13, num. 8, p. 1598
https://doi.org/10.3390/v13081598
dc.rights.none.fl_str_mv cc-by (c) Brotons, Pedro et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Brotons, Pedro et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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