Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task

Introduction: Subjective Cognitive Decline (SCD) is considered a preclinical stage within the AD continuum. Knowledge about the functional changes in the brain associated with episodic memory retrieval and novelty recognition in people with SCD is currently very limited. Method: The study aimed to e...

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Autores: Rivas Fernández, Miguel Ángel, Varela-López, Benxamín, Zurrón Ocio, Montserrat, Lindín Novo, Mónica, Díaz Fernández, Fernando, Galdo Álvarez, Santiago
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/38977
Acceso en línea:https://hdl.handle.net/10347/38977
Access Level:acceso abierto
Palabra clave:Alzheimer's Disease (AD)
Subjective Cognitive Decline (SCD)
Episodic memory retrieval
Novelty recognition
Default Mode Network (DMN)
Fronto-parietal control network (FPCN)
Functional magnetic resonance imaging (fMRI)
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spelling Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory taskRivas Fernández, Miguel ÁngelVarela-López, BenxamínZurrón Ocio, MontserratLindín Novo, MónicaDíaz Fernández, FernandoGaldo Álvarez, SantiagoAlzheimer's Disease (AD)Subjective Cognitive Decline (SCD)Episodic memory retrievalNovelty recognitionDefault Mode Network (DMN)Fronto-parietal control network (FPCN)Functional magnetic resonance imaging (fMRI)Introduction: Subjective Cognitive Decline (SCD) is considered a preclinical stage within the AD continuum. Knowledge about the functional changes in the brain associated with episodic memory retrieval and novelty recognition in people with SCD is currently very limited. Method: The study aimed to evaluate behavioural and neurofunctional changes in individuals with SCD, measured relative to a control group, during successful episodic memory retrieval and novelty recognition, as well as to compare the functional connectivity patterns related to these cognitive processes within the Default Mode Network (DMN) in both groups. Participants performed an old/new recognition memory task with words while the BOLD signal was acquired. Results: No between-group differences were observed in the performance of the episodic memory task. However, during the successful recognition of old words, the SCD group showed brain hypoactivity in the right rolandic operculum and reduced functional connectivity between the DMN and the fronto-parietal control network (FPCN). During the correct identification of new words, the SCD group also showed reduced connectivity between the DMN and the FPCN, and lower connectivity within the DMN. Conclusion: Despite the absence of objective evidence of cognitive impairment, people with SCD display several changes in brain activity and connectivity associated with episodic memory retrieval and novelty recognition.ElsevierUniversidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e PsicobioloxíaUniversidade de Santiago de Compostela. Instituto de Psicoloxía (IPsiUS)20242024-11-0120242024-11-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/38977reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 PSI2014-55316-C3-3-R EVOLUCION DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES PSICOFISIOLOGICOS Y DE NEUROIMAGEN FUNCIONALAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PSI2017-89389-C2-2-R ESTUDIO LONGITUDINAL DEL DETERIORO COGNITIVO EN EL DCL Y EA CON MARCADORES NEUROCOGNITIVOS. EFECTOS DE LA EST ELECTRICA T. EN UN PROGRAMA INTEGRADO DE EST. COGNITIVAAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-114521RB-C21 PREDICCION DE LA PROGRESION DESDE EL DECLIVE COGNITIVO SUBJETIVO HASTA LA DEMENCIA A LO LARGO DEL CONTINUO EVOLUTIVO UTILIZANDO MARCADORES COGNITIVOS, AFECTIVOS Y FUNCIONALESopen accesshttp://purl.org/coar/access_right/c_abf2© 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/389772026-06-15T12:47:27Z
dc.title.none.fl_str_mv Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
title Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
spellingShingle Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
Rivas Fernández, Miguel Ángel
Alzheimer's Disease (AD)
Subjective Cognitive Decline (SCD)
Episodic memory retrieval
Novelty recognition
Default Mode Network (DMN)
Fronto-parietal control network (FPCN)
Functional magnetic resonance imaging (fMRI)
title_short Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
title_full Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
title_fullStr Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
title_full_unstemmed Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
title_sort Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task
dc.creator.none.fl_str_mv Rivas Fernández, Miguel Ángel
Varela-López, Benxamín
Zurrón Ocio, Montserrat
Lindín Novo, Mónica
Díaz Fernández, Fernando
Galdo Álvarez, Santiago
author Rivas Fernández, Miguel Ángel
author_facet Rivas Fernández, Miguel Ángel
Varela-López, Benxamín
Zurrón Ocio, Montserrat
Lindín Novo, Mónica
Díaz Fernández, Fernando
Galdo Álvarez, Santiago
author_role author
author2 Varela-López, Benxamín
Zurrón Ocio, Montserrat
Lindín Novo, Mónica
Díaz Fernández, Fernando
Galdo Álvarez, Santiago
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía
Universidade de Santiago de Compostela. Instituto de Psicoloxía (IPsiUS)
dc.subject.none.fl_str_mv Alzheimer's Disease (AD)
Subjective Cognitive Decline (SCD)
Episodic memory retrieval
Novelty recognition
Default Mode Network (DMN)
Fronto-parietal control network (FPCN)
Functional magnetic resonance imaging (fMRI)
topic Alzheimer's Disease (AD)
Subjective Cognitive Decline (SCD)
Episodic memory retrieval
Novelty recognition
Default Mode Network (DMN)
Fronto-parietal control network (FPCN)
Functional magnetic resonance imaging (fMRI)
description Introduction: Subjective Cognitive Decline (SCD) is considered a preclinical stage within the AD continuum. Knowledge about the functional changes in the brain associated with episodic memory retrieval and novelty recognition in people with SCD is currently very limited. Method: The study aimed to evaluate behavioural and neurofunctional changes in individuals with SCD, measured relative to a control group, during successful episodic memory retrieval and novelty recognition, as well as to compare the functional connectivity patterns related to these cognitive processes within the Default Mode Network (DMN) in both groups. Participants performed an old/new recognition memory task with words while the BOLD signal was acquired. Results: No between-group differences were observed in the performance of the episodic memory task. However, during the successful recognition of old words, the SCD group showed brain hypoactivity in the right rolandic operculum and reduced functional connectivity between the DMN and the fronto-parietal control network (FPCN). During the correct identification of new words, the SCD group also showed reduced connectivity between the DMN and the FPCN, and lower connectivity within the DMN. Conclusion: Despite the absence of objective evidence of cognitive impairment, people with SCD display several changes in brain activity and connectivity associated with episodic memory retrieval and novelty recognition.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-11-01
2024
2024-11-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/38977
url https://hdl.handle.net/10347/38977
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 PSI2014-55316-C3-3-R EVOLUCION DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES PSICOFISIOLOGICOS Y DE NEUROIMAGEN FUNCIONAL
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PSI2017-89389-C2-2-R ESTUDIO LONGITUDINAL DEL DETERIORO COGNITIVO EN EL DCL Y EA CON MARCADORES NEUROCOGNITIVOS. EFECTOS DE LA EST ELECTRICA T. EN UN PROGRAMA INTEGRADO DE EST. COGNITIVA
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-114521RB-C21 PREDICCION DE LA PROGRESION DESDE EL DECLIVE COGNITIVO SUBJETIVO HASTA LA DEMENCIA A LO LARGO DEL CONTINUO EVOLUTIVO UTILIZANDO MARCADORES COGNITIVOS, AFECTIVOS Y FUNCIONALES
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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