Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies...

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Autores: Bastard, Paul|||0000-0002-5926-8437, Rosen, Lindsey|||0000-0001-5894-3878, Zhang, Qian|||0000-0002-9040-3289, Michailidis, Eleftherios|||0000-0002-9907-4346, Hoffmann, Hans-Heinrich|||0000-0003-0554-0244, Zhang, Yu|||0000-0002-0332-0013, Dorgham, Karim|||0000-0001-9539-3203, Philippot, Quentin, Rosain, Jérémie|||0000-0002-2822-161X, Béziat, Vivien|||0000-0002-4020-824X, Manry, Jeremy|||0000-0001-5998-2051, Shaw, Elana|||0000-0001-9265-8026, Haljasmägi, Liis|||0000-0001-7162-9808, Peterson, Pärt|||0000-0001-6755-791X, Lorenzo, Lazaro|||0000-0001-6648-8684, Bizien, Lucy|||0000-0001-9163-9122, Trouillet-Assant, Sophie|||0000-0001-6439-4705, Dobbs, Kerry|||0000-0002-3432-3137, Almeida de Jesus, Adriana, Belot, Alexandre|||0000-0003-4902-5332, Kallaste, Anne|||0000-0002-7492-667X, Catherinot, Emilie, Tandjaoui-Lambiotte redondo, Yacine|||0000-0003-1123-4788, Le Pen, Jérémie|||0000-0001-7025-9526, Kerner, Gaspard|||0000-0003-0146-9428, Bigio, Benedetta|||0000-0001-7291-5638, Seeleuthner, Yoann|||0000-0002-1878-8567, Yang, Rui|||0000-0003-4427-2158, Bolze, Alexandre|||0000-0001-7399-2766, Spaan, András|||0000-0001-5981-7259, Delmonte, Ottavia M., Abers, Michael S., Aiuti, Alessandro|||0000-0002-5398-1717, Casari, Giorgio|||0000-0002-0115-8980, Lampasona, Vito|||0000-0001-5162-8445, Piemonti, Lorenzo|||0000-0002-2172-2198, Ciceri, Fabio|||0000-0003-0873-0123, Bilguvar, Kaya|||0000-0002-7313-7652, Lifton, Richard P., Vasse, Marc, Smadja, David M., Migaud, Mélanie|||0000-0003-3062-1214, Hadjadj, Jérome|||0000-0002-2520-3272, Terrier, Benjamin|||0000-0001-6612-7336, Duffy, Darragh|||0000-0002-8875-2308, Quintana-Murci, Lluis|||0000-0003-2429-6320, van de Beek, Diederik|||0000-0002-4571-044X, Roussel, Lucie|||0000-0001-5355-702X, Vinh, Donald C.|||0000-0003-1347-7767, Tangye, Stuart|||0000-0002-5360-5180, Haerynck, Filomeen|||0000-0001-9161-7361, Dalmau, David|||0000-0003-1936-478X, Martínez Picado, Francisco Javier|||0000-0002-4916-2129, Brodin, Petter|||0000-0002-8103-0046, Nussenzweig, Michel|||0000-0003-0592-8564, Boisson-Dupuis, Stephanie|||0000-0002-7115-116X, Rodríguez-Gallego, Carlos|||0000-0002-4344-8644, Vogt, Guillaume, Mogensen, Trine Hyrup|||0000-0002-1853-9704, Oler, Andrew J.|||0000-0002-6310-0434, Gu, Jingwen, Burbelo, Peter D.|||0000-0003-1717-048X, Cohen, Jeffrey I.|||0000-0003-0238-7176, Biondi, Andrea, Bettini, Laura Rachele|||0000-0002-0280-1704, D'Angio, Mariella|||0000-0001-7889-8576, Bonfanti, Paolo|||0000-0001-7289-8823, Rossignol, Patrick, Mayaux, Julien, Rieux-Laucat, Frédéric|||0000-0001-7858-7866, Husebye, Eystein Sverre|||0000-0002-7886-2976, Fusco, Francesca, Ursini, Matilde Valeria, Imberti, Luisa|||0000-0002-2075-8391, Sottini, Alessandra, Paghera, Simone, Quiros-Roldan, Eugenia, Rossi, Camillo, Castagnoli, Riccardo|||0000-0003-0029-9383, Montagna, Daniela, Licari, Amelia|||0000-0002-1773-6482, Marseglia, Gian Luigi|||0000-0003-3662-0159, Duval, Xavier, Ghosn, Jade, Tsang, John S.|||0000-0003-3186-3047, Goldbach-Mansky, Raphaela|||0000-0001-7865-5769, Kisand, Kai|||0000-0002-5426-4648, Lionakis, Michail S., Puel, Anne|||0000-0003-2603-0323, Zhang, Shein-Ying, Holland, Steven|||0000-0003-3207-5464, Gorochov, Guy|||0000-0003-2097-9677, Jouanguy, Emmanuelle|||0000-0002-7358-9157, Rice, Charles M.|||0000-0003-3087-8079, Cobat, Aurélie|||0000-0001-7209-6257, Notarangelo, Luigi|||0000-0002-8335-0262, Abel, Laurent|||0000-0001-7016-6493, Su, Helen C.|||0000-0002-5582-9110, Casanova, Jean-Laurent|||0000-0002-7782-4169
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:244114
Acceso en línea:https://ddd.uab.cat/record/244114
https://dx.doi.org/urn:doi:10.1126/science.abd4585
Access Level:acceso abierto
Palabra clave:Adult
Aged
Aged, 80 and over
Antibodies, Neutralizing
Asymptomatic Infections
Autoantibodies
Betacoronavirus
Case-Control Studies
Coronavirus Infections
COVID-19
Critical Illness
Female
Humans
Immunoglobulin G
Interferon alpha-2
Interferon Type I
Male
Middle Aged
Pandemics
Pneumonia, Viral
Descripción
Sumario:Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

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