Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status

Background: The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical t...

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Authors: Casós, Kelly, Ferrer Curriu, Gemma, Soler Ferrer, Paula, Pérez, María-Llanos, Permanyer, Eduard, Blasco Lucas, Arnau, Gracia Baena, Juan Manuel, Castro, Miguel A., Sureda, Carlos, Barquinero, Jordi, Galiñanes, Manuel
Format: article
Status:Published version
Publication Date:2017
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/83890
Online Access:https://doi.org/10.1371/journal.pone.0174588
http://hdl.handle.net/10459.1/83890
Access Level:Open access
Keyword:Heart Diseases
Myocardial Ischemia
Risk Factors
Sex Factors
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spelling Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox statusCasós, KellyFerrer Curriu, GemmaSoler Ferrer, PaulaPérez, María-LlanosPermanyer, EduardBlasco Lucas, ArnauGracia Baena, Juan ManuelCastro, Miguel A.Sureda, CarlosBarquinero, JordiGaliñanes, ManuelHeart DiseasesMyocardial IschemiaRisk FactorsSex FactorsBackground: The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may influence the myocardial response to I/R injury and protection. This study investigated the effect of both on myocardial susceptibility to I/R-induced injury and the protective effects of IPreC. Methods and results: Atrial myocardium from cardiac surgery patients (n = 300) was assigned to one of three groups: aerobic control, I/R alone, and IPreC. Lactate dehydrogenase leakage, as a marker of cell injury, and cell viability were measured. The basal redox status was determined in samples from 90 patients. The response to I/R varied widely. Myocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible. Tissue from females was better protected than tissue from males. Myocardium from patients with mitral valve disease was the least responsive to IPreC. The basal redox status was altered in the myocardium from patients with mitral and aortic valve disease. Conclusions: The response of the myocardium to I/R and IPreC is highly variable and influenced by the underlying cardiac pathology, dyslipidemia, sex, and the basal redox status. These results should be taken into account in the design of future clinical studies on the prevention of I/R injury and protection.Public Library of Science202220222017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1371/journal.pone.0174588http://hdl.handle.net/10459.1/83890http://hdl.handle.net/10459.1/83890reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0174588PLoS One, 2017. Vol. 12, núm. 4cc-by (c) Casós et al., 2017info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/838902026-05-29T05:05:01Z
dc.title.none.fl_str_mv Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
title Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
spellingShingle Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
Casós, Kelly
Heart Diseases
Myocardial Ischemia
Risk Factors
Sex Factors
title_short Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
title_full Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
title_fullStr Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
title_full_unstemmed Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
title_sort Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status
dc.creator.none.fl_str_mv Casós, Kelly
Ferrer Curriu, Gemma
Soler Ferrer, Paula
Pérez, María-Llanos
Permanyer, Eduard
Blasco Lucas, Arnau
Gracia Baena, Juan Manuel
Castro, Miguel A.
Sureda, Carlos
Barquinero, Jordi
Galiñanes, Manuel
author Casós, Kelly
author_facet Casós, Kelly
Ferrer Curriu, Gemma
Soler Ferrer, Paula
Pérez, María-Llanos
Permanyer, Eduard
Blasco Lucas, Arnau
Gracia Baena, Juan Manuel
Castro, Miguel A.
Sureda, Carlos
Barquinero, Jordi
Galiñanes, Manuel
author_role author
author2 Ferrer Curriu, Gemma
Soler Ferrer, Paula
Pérez, María-Llanos
Permanyer, Eduard
Blasco Lucas, Arnau
Gracia Baena, Juan Manuel
Castro, Miguel A.
Sureda, Carlos
Barquinero, Jordi
Galiñanes, Manuel
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Heart Diseases
Myocardial Ischemia
Risk Factors
Sex Factors
topic Heart Diseases
Myocardial Ischemia
Risk Factors
Sex Factors
description Background: The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may influence the myocardial response to I/R injury and protection. This study investigated the effect of both on myocardial susceptibility to I/R-induced injury and the protective effects of IPreC. Methods and results: Atrial myocardium from cardiac surgery patients (n = 300) was assigned to one of three groups: aerobic control, I/R alone, and IPreC. Lactate dehydrogenase leakage, as a marker of cell injury, and cell viability were measured. The basal redox status was determined in samples from 90 patients. The response to I/R varied widely. Myocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible. Tissue from females was better protected than tissue from males. Myocardium from patients with mitral valve disease was the least responsive to IPreC. The basal redox status was altered in the myocardium from patients with mitral and aortic valve disease. Conclusions: The response of the myocardium to I/R and IPreC is highly variable and influenced by the underlying cardiac pathology, dyslipidemia, sex, and the basal redox status. These results should be taken into account in the design of future clinical studies on the prevention of I/R injury and protection.
publishDate 2017
dc.date.none.fl_str_mv 2017
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1371/journal.pone.0174588
http://hdl.handle.net/10459.1/83890
http://hdl.handle.net/10459.1/83890
url https://doi.org/10.1371/journal.pone.0174588
http://hdl.handle.net/10459.1/83890
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0174588
PLoS One, 2017. Vol. 12, núm. 4
dc.rights.none.fl_str_mv cc-by (c) Casós et al., 2017
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Casós et al., 2017
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402701699219456
score 15,811543

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