Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain

Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D). A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic...

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Autores: Pérez, Antonio|||0000-0001-5528-1143, Redondo-Antón, J.|||0000-0003-2661-5866, Romera, I., Lizán, L., Rubio-de Santos, M., Díaz-Cerezo, Silvia, Orozco-Beltrán, D.
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:296633
Acceso en línea:https://ddd.uab.cat/record/296633
https://dx.doi.org/urn:doi:10.1007/s13300-023-01503-4
Access Level:acceso abierto
Palabra clave:Burden of illness
HbA1c
Obesity
Type 2 diabetes mellitus
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spelling Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in SpainA Systematic Literature ReviewPérez, Antonio|||0000-0001-5528-1143Redondo-Antón, J.|||0000-0003-2661-5866Romera, I.Lizán, L.Rubio-de Santos, M.Díaz-Cerezo, SilviaOrozco-Beltrán, D.Burden of illnessHbA1cObesityType 2 diabetes mellitusPoor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D). A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years. Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP. Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/296633https://dx.doi.org/urn:doi:10.1007/s13300-023-01503-4reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2966332026-06-06T12:50:31Z
dc.title.none.fl_str_mv Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
A Systematic Literature Review
title Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
spellingShingle Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
Pérez, Antonio|||0000-0001-5528-1143
Burden of illness
HbA1c
Obesity
Type 2 diabetes mellitus
title_short Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
title_full Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
title_fullStr Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
title_full_unstemmed Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
title_sort Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain
dc.creator.none.fl_str_mv Pérez, Antonio|||0000-0001-5528-1143
Redondo-Antón, J.|||0000-0003-2661-5866
Romera, I.
Lizán, L.
Rubio-de Santos, M.
Díaz-Cerezo, Silvia
Orozco-Beltrán, D.
author Pérez, Antonio|||0000-0001-5528-1143
author_facet Pérez, Antonio|||0000-0001-5528-1143
Redondo-Antón, J.|||0000-0003-2661-5866
Romera, I.
Lizán, L.
Rubio-de Santos, M.
Díaz-Cerezo, Silvia
Orozco-Beltrán, D.
author_role author
author2 Redondo-Antón, J.|||0000-0003-2661-5866
Romera, I.
Lizán, L.
Rubio-de Santos, M.
Díaz-Cerezo, Silvia
Orozco-Beltrán, D.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Burden of illness
HbA1c
Obesity
Type 2 diabetes mellitus
topic Burden of illness
HbA1c
Obesity
Type 2 diabetes mellitus
description Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D). A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years. Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP. Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/296633
https://dx.doi.org/urn:doi:10.1007/s13300-023-01503-4
url https://ddd.uab.cat/record/296633
https://dx.doi.org/urn:doi:10.1007/s13300-023-01503-4
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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