The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees

The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events. However, less is known about factors affecting mating patterns at a micro-geographic scale. In this study we have analyzed 726,718 autosomal single nucleotide v...

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Detalles Bibliográficos
Autores: Fibla, Joan, Maceda Porto, Iago, 1986-, Laplana, Marina, Guerrero, Montserrat, Martín Álvarez, Miguel, Burgueño, Jesús, Camps, Agustí, Fàbrega, Jordi, Felisart, Josefina, Grané, Joan, Remón, José Luis, Serra, Jordi, Moral, Pedro, Lao Grueso, Oscar, 1976-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/56246
Acceso en línea:http://hdl.handle.net/10230/56246
http://dx.doi.org/10.3389/fgene.2022.1100440
Access Level:acceso abierto
Palabra clave:Bishopric boundaries
Genetic variation
Inbreeding
Population differentiation
Rural catalan Pyrenees
Rural population
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network_name_str España
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dc.title.none.fl_str_mv The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
title The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
spellingShingle The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
Fibla, Joan
Bishopric boundaries
Genetic variation
Inbreeding
Population differentiation
Rural catalan Pyrenees
Rural population
title_short The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
title_full The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
title_fullStr The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
title_full_unstemmed The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
title_sort The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
dc.creator.none.fl_str_mv Fibla, Joan
Maceda Porto, Iago, 1986-
Laplana, Marina
Guerrero, Montserrat
Martín Álvarez, Miguel
Burgueño, Jesús
Camps, Agustí
Fàbrega, Jordi
Felisart, Josefina
Grané, Joan
Remón, José Luis
Serra, Jordi
Moral, Pedro
Lao Grueso, Oscar, 1976-
author Fibla, Joan
author_facet Fibla, Joan
Maceda Porto, Iago, 1986-
Laplana, Marina
Guerrero, Montserrat
Martín Álvarez, Miguel
Burgueño, Jesús
Camps, Agustí
Fàbrega, Jordi
Felisart, Josefina
Grané, Joan
Remón, José Luis
Serra, Jordi
Moral, Pedro
Lao Grueso, Oscar, 1976-
author_role author
author2 Maceda Porto, Iago, 1986-
Laplana, Marina
Guerrero, Montserrat
Martín Álvarez, Miguel
Burgueño, Jesús
Camps, Agustí
Fàbrega, Jordi
Felisart, Josefina
Grané, Joan
Remón, José Luis
Serra, Jordi
Moral, Pedro
Lao Grueso, Oscar, 1976-
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bishopric boundaries
Genetic variation
Inbreeding
Population differentiation
Rural catalan Pyrenees
Rural population
topic Bishopric boundaries
Genetic variation
Inbreeding
Population differentiation
Rural catalan Pyrenees
Rural population
description The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events. However, less is known about factors affecting mating patterns at a micro-geographic scale. In this study we have analyzed 726,718 autosomal single nucleotide variants in 435 individuals from the catalan Pyrenees covering around 200 km of a vast and abrupt region in the north of the Iberian Peninsula, for which we have information about the geographic origin of all grand-parents and parents. At a macro-geographic scale, our analyses recapitulate the genetic gradient observed in Spain. However, we also identified the presence of micro-population substructure among the sampled individuals. Such micro-population substructure does not correlate with geographic barriers such as the expected by the orography of the considered region, but by the bishoprics present in the covered geographic area. These results support that, on top of main human migrations, long ongoing socio-cultural factors have also shaped the genetic diversity observed at rural populations.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/56246
http://dx.doi.org/10.3389/fgene.2022.1100440
url http://hdl.handle.net/10230/56246
http://dx.doi.org/10.3389/fgene.2022.1100440
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Front Genet. 2023 Jan 10;13:1100440
info:eu-repo/grantAgreement/ES/1PE/BFU2015-68759-P
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan PyreneesFibla, JoanMaceda Porto, Iago, 1986-Laplana, MarinaGuerrero, MontserratMartín Álvarez, MiguelBurgueño, JesúsCamps, AgustíFàbrega, JordiFelisart, JosefinaGrané, JoanRemón, José LuisSerra, JordiMoral, PedroLao Grueso, Oscar, 1976-Bishopric boundariesGenetic variationInbreedingPopulation differentiationRural catalan PyreneesRural populationThe genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events. However, less is known about factors affecting mating patterns at a micro-geographic scale. In this study we have analyzed 726,718 autosomal single nucleotide variants in 435 individuals from the catalan Pyrenees covering around 200 km of a vast and abrupt region in the north of the Iberian Peninsula, for which we have information about the geographic origin of all grand-parents and parents. At a macro-geographic scale, our analyses recapitulate the genetic gradient observed in Spain. However, we also identified the presence of micro-population substructure among the sampled individuals. Such micro-population substructure does not correlate with geographic barriers such as the expected by the orography of the considered region, but by the bishoprics present in the covered geographic area. These results support that, on top of main human migrations, long ongoing socio-cultural factors have also shaped the genetic diversity observed at rural populations.This work was supported by the Diputació of Lleida grant to JF. OL and IM acknowledge the support from Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, CERCA Program/Generalitat de Catalunya, Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III, Generalitat de Catalunya through Departament de Salut and Departament d’Empresa i Coneixement, Co-financing with funds from the European Regional Development Fund by the Spanish Ministry of Science and Innovation corresponding to the Programa Operativo FEDER Plurirregional de España (POPE) 2014–2020 and by the Secretaria d’Universitats i Recerca, Departament d’Empresa i Coneixement of the Generalitat de Catalunya corresponding to the Programa Operatiu FEDER de Catalunya 2014–2020. OL gratefully acknowledges the financial support from Ministerio de Economía, Industria y Competitividad BFU 201568759-P and Generalitat de Catalunya (Government of Catalonia)—GRC 2017 SGR 937. IM gratefully acknowledges the financial support from the Government of Catalonia | Agència de Gestió d’Ajuts Universitaris i de Recerca (Agency for Management of University and Research Grants)—GRC 2014 SGR 615. MMA was supported by a FPU15/01251 from Ministerio de Ciencia, innovación y Universidades. MMA acknowledges the financial support from Precipita-FECYT (FBG 309307 project). The samples analyzed in this study are part of a much larger sample whose collection was supported by the project CGL 2011–27866 of the Ministerio de Ciencia y Tecnologia, the Fundació Moret i Marguí to PM.Frontiers202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56246http://dx.doi.org/10.3389/fgene.2022.1100440reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFront Genet. 2023 Jan 10;13:1100440info:eu-repo/grantAgreement/ES/1PE/BFU2015-68759-P© 2023 Fibla, Maceda, Laplana, Guerrero, Álvarez, Burgueño, Camps, Fàbrega, Felisart, Grané, Remón, Serra, Moral and Lao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/562462026-05-29T05:05:01Z
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