Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries

ObjectiveTo describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status.MethodsThis was an observational, cross-sectional and multicentre study with patients who fulfilled the European Spondyloarthropathy Study Group crite...

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Autores: Puche-Larrubia, MA, Ladehesa-Pineda, L, Vázquez-Mellado, J, Escudero-Contreras, A, Gratacós, J, Juanola, X, Collantes-Estévez, E, Font-Ugalde, P, López-Medina, C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p4182
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/4182
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171959467&doi=10.1136%2frmdopen-2023-003235&partnerID=40&md5=e38e5b17fbb16d612b50edd013cde4a8
Access Level:acceso abierto
Palabra clave:spondyloarthritis
arthritis, psoriatic
low back pain
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spelling Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registriesPuche-Larrubia, MALadehesa-Pineda, LVázquez-Mellado, JEscudero-Contreras, AGratacós, JJuanola, XCollantes-Estévez, EFont-Ugalde, PLópez-Medina, Cspondyloarthritisarthritis, psoriaticlow back painObjectiveTo describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status.MethodsThis was an observational, cross-sectional and multicentre study with patients who fulfilled the European Spondyloarthropathy Study Group criteria for SpA from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) united registries. Differences in the first sign(s) or symptom(s) were compared across diagnoses and between HLA-B27 status. The diagnostic delay between patients who start the disease with musculoskeletal manifestations (MMs) and extra-MMs (EMMs) was compared.ResultsA total of 4067 patients were included (2208 from REGISPONSER and 1859 from RESPONDIA) (ankylosing spondylitis (AS): 68.3%, psoriatic arthritis (PsA): 19.9%, undifferentiated SpA: 11.8%). Overall, 3624 (89.1%) patients initiated the disease with MMs and 443 (10.9%) with EMMs. Low back pain (61.7%) and lower-limb arthritis (38.5%) were the most frequent initial symptoms. In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. The diagnostic delay was longer in patients with initial MMs than in those with EMMs (7.2 (34.8) vs 4.5 (7.6) years, respectively).ConclusionIn this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen.BMJ PUBLISHING GROUP2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/4182https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171959467&doi=10.1136%2frmdopen-2023-003235&partnerID=40&md5=e38e5b17fbb16d612b50edd013cde4a8RMD OpenISSN: 20565933reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p41822026-06-21T15:30:37Z
dc.title.none.fl_str_mv Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
title Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
spellingShingle Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
Puche-Larrubia, MA
spondyloarthritis
arthritis, psoriatic
low back pain
title_short Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
title_full Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
title_fullStr Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
title_full_unstemmed Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
title_sort Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
dc.creator.none.fl_str_mv Puche-Larrubia, MA
Ladehesa-Pineda, L
Vázquez-Mellado, J
Escudero-Contreras, A
Gratacós, J
Juanola, X
Collantes-Estévez, E
Font-Ugalde, P
López-Medina, C
author Puche-Larrubia, MA
author_facet Puche-Larrubia, MA
Ladehesa-Pineda, L
Vázquez-Mellado, J
Escudero-Contreras, A
Gratacós, J
Juanola, X
Collantes-Estévez, E
Font-Ugalde, P
López-Medina, C
author_role author
author2 Ladehesa-Pineda, L
Vázquez-Mellado, J
Escudero-Contreras, A
Gratacós, J
Juanola, X
Collantes-Estévez, E
Font-Ugalde, P
López-Medina, C
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv spondyloarthritis
arthritis, psoriatic
low back pain
topic spondyloarthritis
arthritis, psoriatic
low back pain
description ObjectiveTo describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status.MethodsThis was an observational, cross-sectional and multicentre study with patients who fulfilled the European Spondyloarthropathy Study Group criteria for SpA from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) united registries. Differences in the first sign(s) or symptom(s) were compared across diagnoses and between HLA-B27 status. The diagnostic delay between patients who start the disease with musculoskeletal manifestations (MMs) and extra-MMs (EMMs) was compared.ResultsA total of 4067 patients were included (2208 from REGISPONSER and 1859 from RESPONDIA) (ankylosing spondylitis (AS): 68.3%, psoriatic arthritis (PsA): 19.9%, undifferentiated SpA: 11.8%). Overall, 3624 (89.1%) patients initiated the disease with MMs and 443 (10.9%) with EMMs. Low back pain (61.7%) and lower-limb arthritis (38.5%) were the most frequent initial symptoms. In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. The diagnostic delay was longer in patients with initial MMs than in those with EMMs (7.2 (34.8) vs 4.5 (7.6) years, respectively).ConclusionIn this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/4182
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171959467&doi=10.1136%2frmdopen-2023-003235&partnerID=40&md5=e38e5b17fbb16d612b50edd013cde4a8
url https://i3pt.portalinvestigacion.com/publicaciones/4182
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171959467&doi=10.1136%2frmdopen-2023-003235&partnerID=40&md5=e38e5b17fbb16d612b50edd013cde4a8
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ PUBLISHING GROUP
publisher.none.fl_str_mv BMJ PUBLISHING GROUP
dc.source.none.fl_str_mv RMD Open
ISSN: 20565933
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
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