Syndecans and Pancreatic Ductal Adenocarcinoma

Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a subfamily of proteoglycans, are involved in many physiological processes including cell proliferation,...

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Detalles Bibliográficos
Autores: Betriu, Nausika, Bertran-Mas, Juan, Andreeva, Anna, Alonso, Anna, Semino, Carlos
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/3923
Acceso en línea:http://hdl.handle.net/20.500.14342/3923
https://doi.org/10.3390/biom11030349
Access Level:acceso abierto
Palabra clave:Pancreatic ductal adenocarcinoma
Syndecans
Proteoglycans
Tumor progression
Angiogenesis
Pàncrees--Tumors
Proteoglicans
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spelling Syndecans and Pancreatic Ductal AdenocarcinomaBetriu, NausikaBertran-Mas, JuanAndreeva, AnnaAlonso, AnnaSemino, CarlosPancreatic ductal adenocarcinomaSyndecansProteoglycansTumor progressionAngiogenesisPàncrees--TumorsProteoglicans616Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a subfamily of proteoglycans, are involved in many physiological processes including cell proliferation, adhesion, and migration. Syndecans are physiologically found in many cell types and their interactions with other macromolecules enhance many pathways. In particular, extracellular matrix components, growth factors, and integrins collect the majority of syndecans associations acting as biochemical, physical, and mechanical transducers. Syndecans are transmembrane glycoproteins, but occasionally their extracellular domain can be released from the cell surface by the action of matrix metalloproteinases, converting them into soluble molecules that are capable of binding distant molecules such as extracellular matrix (ECM) components, growth factor receptors, and integrins from other cells. In this review, we explore the role of syndecans in tumorigenesis as well as their potential as therapeutic targets. Finally, this work reviews the contribution of syndecan-1 and syndecan-2 in PDAC progression and illustrates its potential to be targeted in future treatments for this devastating disease.info:eu-repo/semantics/publishedVersionMDPIUniversitat Ramon Llull. IQS202420242021info:eu-repo/semantics/article22 p.application/pdfhttp://hdl.handle.net/20.500.14342/3923https://doi.org/10.3390/biom11030349reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésBiomoleculesinfo:eu-repo/grantAgreement/MICINN/PN I+D/RTI2018-096455-B-I00© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/39232026-06-21T06:40:37Z
dc.title.none.fl_str_mv Syndecans and Pancreatic Ductal Adenocarcinoma
title Syndecans and Pancreatic Ductal Adenocarcinoma
spellingShingle Syndecans and Pancreatic Ductal Adenocarcinoma
Betriu, Nausika
Pancreatic ductal adenocarcinoma
Syndecans
Proteoglycans
Tumor progression
Angiogenesis
Pàncrees--Tumors
Proteoglicans
616
title_short Syndecans and Pancreatic Ductal Adenocarcinoma
title_full Syndecans and Pancreatic Ductal Adenocarcinoma
title_fullStr Syndecans and Pancreatic Ductal Adenocarcinoma
title_full_unstemmed Syndecans and Pancreatic Ductal Adenocarcinoma
title_sort Syndecans and Pancreatic Ductal Adenocarcinoma
dc.creator.none.fl_str_mv Betriu, Nausika
Bertran-Mas, Juan
Andreeva, Anna
Alonso, Anna
Semino, Carlos
author Betriu, Nausika
author_facet Betriu, Nausika
Bertran-Mas, Juan
Andreeva, Anna
Alonso, Anna
Semino, Carlos
author_role author
author2 Bertran-Mas, Juan
Andreeva, Anna
Alonso, Anna
Semino, Carlos
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Pancreatic ductal adenocarcinoma
Syndecans
Proteoglycans
Tumor progression
Angiogenesis
Pàncrees--Tumors
Proteoglicans
616
topic Pancreatic ductal adenocarcinoma
Syndecans
Proteoglycans
Tumor progression
Angiogenesis
Pàncrees--Tumors
Proteoglicans
616
description Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a subfamily of proteoglycans, are involved in many physiological processes including cell proliferation, adhesion, and migration. Syndecans are physiologically found in many cell types and their interactions with other macromolecules enhance many pathways. In particular, extracellular matrix components, growth factors, and integrins collect the majority of syndecans associations acting as biochemical, physical, and mechanical transducers. Syndecans are transmembrane glycoproteins, but occasionally their extracellular domain can be released from the cell surface by the action of matrix metalloproteinases, converting them into soluble molecules that are capable of binding distant molecules such as extracellular matrix (ECM) components, growth factor receptors, and integrins from other cells. In this review, we explore the role of syndecans in tumorigenesis as well as their potential as therapeutic targets. Finally, this work reviews the contribution of syndecan-1 and syndecan-2 in PDAC progression and illustrates its potential to be targeted in future treatments for this devastating disease.
publishDate 2021
dc.date.none.fl_str_mv 2021
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/3923
https://doi.org/10.3390/biom11030349
url http://hdl.handle.net/20.500.14342/3923
https://doi.org/10.3390/biom11030349
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomolecules
info:eu-repo/grantAgreement/MICINN/PN I+D/RTI2018-096455-B-I00
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
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