TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2

PURPOSE: During intestinal inflammation TNFα levels are increased and as a consequence malabsorption of nutrients may occur. We have previously demonstrated that TNFα inhibits galactose, fructose and leucine intestinal absorption in animal models. In continuation with our work, the purpose of the pr...

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Autores: Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26, Barber, A. (Ana)|||/items/6a842b4d-9beb-48a1-acb4-87f25c3bfab8, Lostao-Crespo, M.P. (María Pilar)|||/items/0c37f16e-d88c-407f-8cf7-18042cd3cfa9, Rodriguez-Yoldi, M.J. (M.J.)|||/items/69cd5787-9aae-4bc5-b334-74c8fe9b965e, Gascón-Corella, S. (Silvia)|||/items/d07bf664-35a2-4cb7-a383-33a13c970a0a, Sanchez, O. (O.)|||/items/9a1c6321-1af1-4881-a47e-044eaaf5076a
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/34262
Acceso en línea:https://hdl.handle.net/10171/34262
Access Level:acceso abierto
Palabra clave:Caco-2 cells
GLUT5
PKC
SGLT1
TNF-α
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spelling TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26Barber, A. (Ana)|||/items/6a842b4d-9beb-48a1-acb4-87f25c3bfab8Lostao-Crespo, M.P. (María Pilar)|||/items/0c37f16e-d88c-407f-8cf7-18042cd3cfa9Rodriguez-Yoldi, M.J. (M.J.)|||/items/69cd5787-9aae-4bc5-b334-74c8fe9b965eGascón-Corella, S. (Silvia)|||/items/d07bf664-35a2-4cb7-a383-33a13c970a0aSanchez, O. (O.)|||/items/9a1c6321-1af1-4881-a47e-044eaaf5076aCaco-2 cellsGLUT5PKCSGLT1TNF-αPURPOSE: During intestinal inflammation TNFα levels are increased and as a consequence malabsorption of nutrients may occur. We have previously demonstrated that TNFα inhibits galactose, fructose and leucine intestinal absorption in animal models. In continuation with our work, the purpose of the present study was to investigate in the human intestinal epithelial cell line Caco-2, the effect of TNFα on sugar transport and to identify the intracellular mechanisms involved. METHODS: Caco-2 cells were grown on culture plates and pre-incubated during different periods with various TNFα concentrations before measuring the apical uptake of galactose, α-methyl-glucoside (MG) or fructose for 15 min. To elucidate the signaling pathway implicated, cells were pre-incubated for 30min with the PKA inhibitor H-89 or the PKC inhibitor chelerythrine, before measuring the sugar uptake. The expression in the apical membrane of the transporters implicated in the sugars uptake process (SGLT1 and GLUT5) was determined by Western blot. RESULTS: TNFα inhibited 0.1mM MG uptake after pre-incubation of the cells for 6-48h with the cytokine and in the absence of cytokine pre-incubation. In contrast, 5mM fructose uptake was stimulated by TNFα only after long pre-incubation times (24 and 48 h). These effects were mediated by the binding of the cytokine to its specific receptor TNFR1, present in the apical membrane of the Caco-2 cells. Analysis of the expression of the MG and fructose transporters at the brush border membrane of the cells, after 24h pre-incubation with the cytokine, revealed decrease on the amount of SGLT1 and increase on the amount of GLUT5 proteins. Short-term inhibition of MG transport by TNFα was not modified by H-89 but was blocked by chelerythrine. CONCLUSIONS: SGLT1 and GLUT5 expression in the plasma membrane is regulated by TNFα in the human epithelial cell line Caco-2 cells, leading to alteration on sugars transport, suggesting that TNFα could be considered as a physiological local regulator of nutrients absorption in response to an intestinal inflammatory status.W.B. SaundersDadun. Depósito Académico Digital Universidad de Navarra20132013-10-2320132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10171/34262reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/342622026-06-21T12:47:57Z
dc.title.none.fl_str_mv TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
title TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
spellingShingle TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26
Caco-2 cells
GLUT5
PKC
SGLT1
TNF-α
title_short TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
title_full TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
title_fullStr TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
title_full_unstemmed TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
title_sort TNFalpha regulates sugar transporters in the human intestinal epithelial cell line Caco-2
dc.creator.none.fl_str_mv Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26
Barber, A. (Ana)|||/items/6a842b4d-9beb-48a1-acb4-87f25c3bfab8
Lostao-Crespo, M.P. (María Pilar)|||/items/0c37f16e-d88c-407f-8cf7-18042cd3cfa9
Rodriguez-Yoldi, M.J. (M.J.)|||/items/69cd5787-9aae-4bc5-b334-74c8fe9b965e
Gascón-Corella, S. (Silvia)|||/items/d07bf664-35a2-4cb7-a383-33a13c970a0a
Sanchez, O. (O.)|||/items/9a1c6321-1af1-4881-a47e-044eaaf5076a
author Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26
author_facet Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26
Barber, A. (Ana)|||/items/6a842b4d-9beb-48a1-acb4-87f25c3bfab8
Lostao-Crespo, M.P. (María Pilar)|||/items/0c37f16e-d88c-407f-8cf7-18042cd3cfa9
Rodriguez-Yoldi, M.J. (M.J.)|||/items/69cd5787-9aae-4bc5-b334-74c8fe9b965e
Gascón-Corella, S. (Silvia)|||/items/d07bf664-35a2-4cb7-a383-33a13c970a0a
Sanchez, O. (O.)|||/items/9a1c6321-1af1-4881-a47e-044eaaf5076a
author_role author
author2 Barber, A. (Ana)|||/items/6a842b4d-9beb-48a1-acb4-87f25c3bfab8
Lostao-Crespo, M.P. (María Pilar)|||/items/0c37f16e-d88c-407f-8cf7-18042cd3cfa9
Rodriguez-Yoldi, M.J. (M.J.)|||/items/69cd5787-9aae-4bc5-b334-74c8fe9b965e
Gascón-Corella, S. (Silvia)|||/items/d07bf664-35a2-4cb7-a383-33a13c970a0a
Sanchez, O. (O.)|||/items/9a1c6321-1af1-4881-a47e-044eaaf5076a
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Caco-2 cells
GLUT5
PKC
SGLT1
TNF-α
topic Caco-2 cells
GLUT5
PKC
SGLT1
TNF-α
description PURPOSE: During intestinal inflammation TNFα levels are increased and as a consequence malabsorption of nutrients may occur. We have previously demonstrated that TNFα inhibits galactose, fructose and leucine intestinal absorption in animal models. In continuation with our work, the purpose of the present study was to investigate in the human intestinal epithelial cell line Caco-2, the effect of TNFα on sugar transport and to identify the intracellular mechanisms involved. METHODS: Caco-2 cells were grown on culture plates and pre-incubated during different periods with various TNFα concentrations before measuring the apical uptake of galactose, α-methyl-glucoside (MG) or fructose for 15 min. To elucidate the signaling pathway implicated, cells were pre-incubated for 30min with the PKA inhibitor H-89 or the PKC inhibitor chelerythrine, before measuring the sugar uptake. The expression in the apical membrane of the transporters implicated in the sugars uptake process (SGLT1 and GLUT5) was determined by Western blot. RESULTS: TNFα inhibited 0.1mM MG uptake after pre-incubation of the cells for 6-48h with the cytokine and in the absence of cytokine pre-incubation. In contrast, 5mM fructose uptake was stimulated by TNFα only after long pre-incubation times (24 and 48 h). These effects were mediated by the binding of the cytokine to its specific receptor TNFR1, present in the apical membrane of the Caco-2 cells. Analysis of the expression of the MG and fructose transporters at the brush border membrane of the cells, after 24h pre-incubation with the cytokine, revealed decrease on the amount of SGLT1 and increase on the amount of GLUT5 proteins. Short-term inhibition of MG transport by TNFα was not modified by H-89 but was blocked by chelerythrine. CONCLUSIONS: SGLT1 and GLUT5 expression in the plasma membrane is regulated by TNFα in the human epithelial cell line Caco-2 cells, leading to alteration on sugars transport, suggesting that TNFα could be considered as a physiological local regulator of nutrients absorption in response to an intestinal inflammatory status.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-10-23
2013
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/34262
url https://hdl.handle.net/10171/34262
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv W.B. Saunders
publisher.none.fl_str_mv W.B. Saunders
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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