Arrhythmic genotypes in dilated cardiomyopathy and risk of advanced heart failure

Background and Certain genetic forms of dilated cardiomyopathy (DCM) entail a higher arrhythmic risk. It is unknown whether DCM pa-aims tients with high-risk arrhythmic genotypes also develop more advanced heart failure (AHF) complications. AHF events were studied according to DCM genotype. Methods...

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Detalles Bibliográficos
Autores: Mora-Ayestarán, Nerea, Ochoa, Juan Pablo, Gómez-González, Cristina, Navarro-Peñalver, Marina, Gallego-Delgado, María, Larrañaga-Moreira, José M., Robles-Mezcua, Ainhoa, Basurte-Elorz, María Teresa, Rodriguez-Palomares, Jose Fernando, Climent-Paya, Vicente, Jiménez-Jaímez, Juan, Mogollón-Jiménez, Maria Victoria, García-Granja, Pablo Elpidio, García-Álvarez, Ana, Peña-Peña, María Luisa, Barredo, María Alvarez, Ripoll-Vera, Tomas, Palomino-Doza, Julián, Bayes-Genis, Antoni, Tirón, Coloma, Fernández, Ana Isabel, Sabater-Molina, María, Toranzo, Inés, Crespo-Leiro, María G., Doncel-Abad, Victoria, Lacuey-Lecumberri, Gemma, Limeres-Freire, Javier, García-Álvarez, Maria I., Cabrera-Borrego, Eva, El Maalem, Zineb Kounka Ait, Vilches, Silvia, González-López, Esther, Villacorta, Eduardo, García-Pinilla, José M., Barriales-Villa, Roberto, Gimeno-Blanes, Juan Ramón, Garcia-Pavia, Pablo, Domínguez, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::6c12c3908bce92687fc645425a1250a1
Acceso en línea:http://hdl.handle.net/10256/28844
https://hdl.handle.net/10256/28844
Access Level:acceso abierto
Palabra clave:Genes
Heart failure
Prognosis
Cor -- Malalties
Heart -- Diseases
Gens
Insuficiència cardíaca
Prognosi
Sudden death
Mort sobtada
Descripción
Sumario:Background and Certain genetic forms of dilated cardiomyopathy (DCM) entail a higher arrhythmic risk. It is unknown whether DCM pa-aims tients with high-risk arrhythmic genotypes also develop more advanced heart failure (AHF) complications. AHF events were studied according to DCM genotype. Methods Clinical data from 1203 genotyped DCM patients were collected from 19 Spanish centres. Patients were classified into high-risk arrhythmic genotypes (LMNA, FLNC, desmosomal genes, PLN, TMEM43, RBM20), TTN, other genes, and genotype negative (Gen−). The primary endpoint was a composite of AHF events (ventricular assist device implantation, heart transplant, and AHF-related mortality). The secondary endpoint was a combination of malignant ventricular arrhythmias (MVA). Results A DCM-causing variant was identified in a high-risk arrhythmic gene in 185 patients (15.4%), 193 (16.0%) had variants in TTN, 134 (11.1%) in other genes, and 691 (57.4%) were Gen−. After a median follow-up of 5.7 years (interquartile range 2.9–9.1 years), AHF events occurred in 45 (24.3%) patients in the high-risk arrhythmic group, while in 25 (18.7%), 25 (13.0%), and 70 (10.1%) patients with other genotypes, TTN, and Gen−, respectively (hazard ratio 1.85, 95% confidence interval 1.31–2.61 for high-risk arrhythmic genes compared with other groups). MVA occurred in 55 patients (29.7%) (hazard ratio 2.52, 95% confidence interval 1.81–3.51 for high-risk genotypes vs other groups). High-risk arrhythmic genotype was the main independent predictor of AHF in multivariate analysis. High-risk arrhythmic genotype and late gadolinium enhancement were independent predictors of MVA. Conclusions Patients with high-risk arrhythmic genotypes also experience more AHF events, supporting a differential therapeutic approach in this group of patients beyond sudden death prevention.

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