Cutaneous allodynia in migraine: A narrative review
Objective: In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. Background: CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has incr...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:dadun_______::50a4b89749feff62a1105487703170f1 |
| Acceso en línea: | https://hdl.handle.net/10171/124415 |
| Access Level: | acceso abierto |
| Palabra clave: | Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
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Cutaneous allodynia in migraine: A narrative reviewMínguez-Olaondo, A. (Ane)|||/items/183ce45e-af64-4049-b011-55e737f85d77Quintas, S. (Sonia)|||/items/03f29031-467a-4113-8538-f15a59cf3e92Morollón-Sánchez-Mateo, N. (Noemí)|||/items/5714f877-d8ba-4811-b743-da2a9515345aLópez-Bravo, A. (Alba)|||/items/36c6130d-bf16-4fe9-acd0-cd7df7bbd0faVila-Pueyo, M. (Marta)|||/items/7d19083c-494e-405a-8b55-cea575601030Grozeva, V. (Vesselina)|||/items/5fc30542-dc7f-4731-8288-07487605011bBelvís, R. (R.)|||/items/4f9cac53-4caf-4537-b1e4-2269b66d8a7eSantos-Lasaosa, S. (Sonia)|||/items/14213b29-8360-4b5c-aa14-da99cf287d48Irimia-Sieira, P. (Pablo)|||/items/6e718e54-cceb-41cf-afeb-c5caea0e03a6Cutaneous allodyniaMigraineMigraine chronificationRisk factorsTreatmentObjective: In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. Background: CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. Methods: We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. Results: The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. Conclusions: CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions.Frontiers Media S.A.Dadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/124415reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:dadun_______::50a4b89749feff62a1105487703170f12026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Cutaneous allodynia in migraine: A narrative review |
| title |
Cutaneous allodynia in migraine: A narrative review |
| spellingShingle |
Cutaneous allodynia in migraine: A narrative review Mínguez-Olaondo, A. (Ane)|||/items/183ce45e-af64-4049-b011-55e737f85d77 Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
| title_short |
Cutaneous allodynia in migraine: A narrative review |
| title_full |
Cutaneous allodynia in migraine: A narrative review |
| title_fullStr |
Cutaneous allodynia in migraine: A narrative review |
| title_full_unstemmed |
Cutaneous allodynia in migraine: A narrative review |
| title_sort |
Cutaneous allodynia in migraine: A narrative review |
| dc.creator.none.fl_str_mv |
Mínguez-Olaondo, A. (Ane)|||/items/183ce45e-af64-4049-b011-55e737f85d77 Quintas, S. (Sonia)|||/items/03f29031-467a-4113-8538-f15a59cf3e92 Morollón-Sánchez-Mateo, N. (Noemí)|||/items/5714f877-d8ba-4811-b743-da2a9515345a López-Bravo, A. (Alba)|||/items/36c6130d-bf16-4fe9-acd0-cd7df7bbd0fa Vila-Pueyo, M. (Marta)|||/items/7d19083c-494e-405a-8b55-cea575601030 Grozeva, V. (Vesselina)|||/items/5fc30542-dc7f-4731-8288-07487605011b Belvís, R. (R.)|||/items/4f9cac53-4caf-4537-b1e4-2269b66d8a7e Santos-Lasaosa, S. (Sonia)|||/items/14213b29-8360-4b5c-aa14-da99cf287d48 Irimia-Sieira, P. (Pablo)|||/items/6e718e54-cceb-41cf-afeb-c5caea0e03a6 |
| author |
Mínguez-Olaondo, A. (Ane)|||/items/183ce45e-af64-4049-b011-55e737f85d77 |
| author_facet |
Mínguez-Olaondo, A. (Ane)|||/items/183ce45e-af64-4049-b011-55e737f85d77 Quintas, S. (Sonia)|||/items/03f29031-467a-4113-8538-f15a59cf3e92 Morollón-Sánchez-Mateo, N. (Noemí)|||/items/5714f877-d8ba-4811-b743-da2a9515345a López-Bravo, A. (Alba)|||/items/36c6130d-bf16-4fe9-acd0-cd7df7bbd0fa Vila-Pueyo, M. (Marta)|||/items/7d19083c-494e-405a-8b55-cea575601030 Grozeva, V. (Vesselina)|||/items/5fc30542-dc7f-4731-8288-07487605011b Belvís, R. (R.)|||/items/4f9cac53-4caf-4537-b1e4-2269b66d8a7e Santos-Lasaosa, S. (Sonia)|||/items/14213b29-8360-4b5c-aa14-da99cf287d48 Irimia-Sieira, P. (Pablo)|||/items/6e718e54-cceb-41cf-afeb-c5caea0e03a6 |
| author_role |
author |
| author2 |
Quintas, S. (Sonia)|||/items/03f29031-467a-4113-8538-f15a59cf3e92 Morollón-Sánchez-Mateo, N. (Noemí)|||/items/5714f877-d8ba-4811-b743-da2a9515345a López-Bravo, A. (Alba)|||/items/36c6130d-bf16-4fe9-acd0-cd7df7bbd0fa Vila-Pueyo, M. (Marta)|||/items/7d19083c-494e-405a-8b55-cea575601030 Grozeva, V. (Vesselina)|||/items/5fc30542-dc7f-4731-8288-07487605011b Belvís, R. (R.)|||/items/4f9cac53-4caf-4537-b1e4-2269b66d8a7e Santos-Lasaosa, S. (Sonia)|||/items/14213b29-8360-4b5c-aa14-da99cf287d48 Irimia-Sieira, P. (Pablo)|||/items/6e718e54-cceb-41cf-afeb-c5caea0e03a6 |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
| topic |
Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
| description |
Objective: In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. Background: CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. Methods: We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. Results: The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. Conclusions: CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/124415 |
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https://hdl.handle.net/10171/124415 |
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Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Frontiers Media S.A. |
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Frontiers Media S.A. |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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