From Mitochondria to Atherosclerosis: The Inflammation Path
© 2021 by the authors
| Autores: | , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2021 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositório: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/241619 |
| Acesso em linha: | http://hdl.handle.net/10261/241619 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Atherosclerosis Mitochondria Inflammation Inflammasome Reactive oxygen species NLRP3 |
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From Mitochondria to Atherosclerosis: The Inflammation PathSuarez-Rivero, Juan M.Pastor-Maldonado, Carmen J.Povea-Cabello, SulevaÁlvarez-Córdoba, MónicaVillalón-García, IreneTalaverón-Rey, MartaSuárez-Carrillo, AlejandraMunuera, ManuelSánchez-Alcázar, José AntonioAtherosclerosisMitochondriaInflammationInflammasomeReactive oxygen speciesNLRP3© 2021 by the authorsInflammation is a key process in metazoan organisms due to its relevance for innate defense against infections and tissue damage. However, inflammation is also implicated in pathological processes such as atherosclerosis. Atherosclerosis is a chronic inflammatory disease of the arterial wall where unstable atherosclerotic plaque rupture causing platelet aggregation and thrombosis may compromise the arterial lumen, leading to acute or chronic ischemic syndromes. In this review, we will focus on the role of mitochondria in atherosclerosis while keeping inflammation as a link. Mitochondria are the main source of cellular energy. Under stress, mitochondria are also capable of controlling inflammation through the production of reactive oxygen species (ROS) and the release of mitochondrial components, such as mitochondrial DNA (mtDNA), into the cytoplasm or into the extracellular matrix, where they act as danger signals when recognized by innate immune receptors. Primary or secondary mitochondrial dysfunctions are associated with the initiation and progression of atherosclerosis by elevating the production of ROS, altering mitochondrial dynamics and energy supply, as well as promoting inflammation. Knowing and understanding the pathways behind mitochondrial-based inflammation in atheroma progression is essential to discovering alternative or complementary treatments.This work was supported by the FIS PI16/00786 (2016) and FIS PI19/00377 (2019), Instituto de Salud Carlos III, Ministerio de Sanidad, Spain, and Fondo Europeo de Desarrollo Regional (FEDER Unión Europea), Spanish Ministry of Education, Culture and Sport, Spain. This activity has been co-financed by the European Regional Development Fund (ERDF) and by the Regional Ministry of Economic Transformation, Industry, Knowledge and Universities of the Junta de Andalucía, within the framework of the ERDF Andalusia operational program 2014–2020 thematic objective “01—Reinforcement of research, technological development and innovation” through the reference research projects CTS-5725 and PY18-850.Multidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIMinisterio de Sanidad (España)European CommissionMinisterio de Educación, Cultura y Deporte (España)Junta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/241619reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/biomedicines9030258Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2416192026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| title |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| spellingShingle |
From Mitochondria to Atherosclerosis: The Inflammation Path Suarez-Rivero, Juan M. Atherosclerosis Mitochondria Inflammation Inflammasome Reactive oxygen species NLRP3 |
| title_short |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| title_full |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| title_fullStr |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| title_full_unstemmed |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| title_sort |
From Mitochondria to Atherosclerosis: The Inflammation Path |
| dc.creator.none.fl_str_mv |
Suarez-Rivero, Juan M. Pastor-Maldonado, Carmen J. Povea-Cabello, Suleva Álvarez-Córdoba, Mónica Villalón-García, Irene Talaverón-Rey, Marta Suárez-Carrillo, Alejandra Munuera, Manuel Sánchez-Alcázar, José Antonio |
| author |
Suarez-Rivero, Juan M. |
| author_facet |
Suarez-Rivero, Juan M. Pastor-Maldonado, Carmen J. Povea-Cabello, Suleva Álvarez-Córdoba, Mónica Villalón-García, Irene Talaverón-Rey, Marta Suárez-Carrillo, Alejandra Munuera, Manuel Sánchez-Alcázar, José Antonio |
| author_role |
author |
| author2 |
Pastor-Maldonado, Carmen J. Povea-Cabello, Suleva Álvarez-Córdoba, Mónica Villalón-García, Irene Talaverón-Rey, Marta Suárez-Carrillo, Alejandra Munuera, Manuel Sánchez-Alcázar, José Antonio |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III Ministerio de Sanidad (España) European Commission Ministerio de Educación, Cultura y Deporte (España) Junta de Andalucía Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Atherosclerosis Mitochondria Inflammation Inflammasome Reactive oxygen species NLRP3 |
| topic |
Atherosclerosis Mitochondria Inflammation Inflammasome Reactive oxygen species NLRP3 |
| description |
© 2021 by the authors |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_dcae04bc Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/241619 |
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http://hdl.handle.net/10261/241619 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
http://dx.doi.org/10.3390/biomedicines9030258 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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