Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

27 Pág. Centro de Investigación en Sanidad Animal (CISA)

Detalles Bibliográficos
Autores: Segner, Helmut, Bailey, Christyn, Tafalla, Carolina, Bo, Jun
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285343
Acceso en línea:http://hdl.handle.net/10261/285343
https://api.elsevier.com/content/abstract/scopus_id/85114040000
Access Level:acceso abierto
Palabra clave:Aryl hydrocarbon receptor
Disease
Environmental pollution
Fish
Halogenated aromatic hydrocarbons
Immunity
Immunotoxicity
Polyaromatic hydrocarbons
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spelling Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?Segner, HelmutBailey, ChristynTafalla, CarolinaBo, JunAryl hydrocarbon receptorDiseaseEnvironmental pollutionFishHalogenated aromatic hydrocarbonsImmunityImmunotoxicityPolyaromatic hydrocarbons27 Pág. Centro de Investigación en Sanidad Animal (CISA)The impact of anthropogenic contaminants on the immune system of fishes is an issue of growing concern. An important xenobiotic receptor that mediates effects of chemicals, such as halogenated aromatic hydrocarbons (HAHs) and polyaromatic hydrocarbons (PAHs), is the aryl hydrocarbon receptor (AhR). Fish toxicological research has focused on the role of this receptor in xenobiotic biotransformation as well as in causing developmental, cardiac, and reproductive toxicity. However, biomedical research has unraveled an important physiological role of the AhR in the immune system, what suggests that this receptor could be involved in immunotoxic effects of environmental contaminants. The aims of the present review are to critically discuss the available knowledge on (i) the expression and possible function of the AhR in the immune systems of teleost fishes; and (ii) the impact of AhR-activating xenobiotics on the immune systems of fish at the levels of immune gene expression, immune cell proliferation and immune cell function, immune pathology, and resistance to infectious disease. The existing information indicates that the AhR is expressed in the fish immune system, but currently, we have little understanding of its physiological role. Exposure to AhR-activating contaminants results in the modulation of numerous immune structural and functional parameters of fish. Despite the diversity of fish species studied and the experimental conditions investigated, the published findings rather uniformly point to immunosuppressive actions of xenobiotic AhR ligands in fish. These effects are often associated with increased disease susceptibility. The fact that fish populations from HAH- and PAH-contaminated environments suffer immune disturbances and elevated disease susceptibility highlights that the immunotoxic effects of AhR-activating xenobiotics bear environmental relevance.H.S. was supported by by the grants 310030E-164266, 31003A_153427, and 31003A_130640 from the Swiss National Science Foundation SNSF. C.B. was funded by Swiss National Science Foundation (SNSF) Post Doc Mobility Fellowship number P400PB_183824. J.B. was supported by the National Natural Science Foundation of China under the number 4197721.Peer reviewedMultidisciplinary Digital Publishing InstituteSwiss National Science FoundationNational Natural Science Foundation of ChinaSegner, Helmut [0000-0002-1783-1295]Bailey, Christyn [0000-0002-0989-4587]Tafalla, Carolina [0000-0002-0860-2976]Bo, Jun [0000-0002-8726-1654]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/285343https://api.elsevier.com/content/abstract/scopus_id/85114040000reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational journal of molecular scienceshttps://doi.org/10.3390/ijms22179460Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2853432026-05-22T06:33:51Z
dc.title.none.fl_str_mv Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
title Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
spellingShingle Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
Segner, Helmut
Aryl hydrocarbon receptor
Disease
Environmental pollution
Fish
Halogenated aromatic hydrocarbons
Immunity
Immunotoxicity
Polyaromatic hydrocarbons
title_short Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
title_full Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
title_fullStr Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
title_full_unstemmed Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
title_sort Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
dc.creator.none.fl_str_mv Segner, Helmut
Bailey, Christyn
Tafalla, Carolina
Bo, Jun
author Segner, Helmut
author_facet Segner, Helmut
Bailey, Christyn
Tafalla, Carolina
Bo, Jun
author_role author
author2 Bailey, Christyn
Tafalla, Carolina
Bo, Jun
author2_role author
author
author
dc.contributor.none.fl_str_mv Swiss National Science Foundation
National Natural Science Foundation of China
Segner, Helmut [0000-0002-1783-1295]
Bailey, Christyn [0000-0002-0989-4587]
Tafalla, Carolina [0000-0002-0860-2976]
Bo, Jun [0000-0002-8726-1654]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aryl hydrocarbon receptor
Disease
Environmental pollution
Fish
Halogenated aromatic hydrocarbons
Immunity
Immunotoxicity
Polyaromatic hydrocarbons
topic Aryl hydrocarbon receptor
Disease
Environmental pollution
Fish
Halogenated aromatic hydrocarbons
Immunity
Immunotoxicity
Polyaromatic hydrocarbons
description 27 Pág. Centro de Investigación en Sanidad Animal (CISA)
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285343
https://api.elsevier.com/content/abstract/scopus_id/85114040000
url http://hdl.handle.net/10261/285343
https://api.elsevier.com/content/abstract/scopus_id/85114040000
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of molecular sciences
https://doi.org/10.3390/ijms22179460
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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