Asymmetric Synthesis of Atropisomeric Amines via Transaminase-Catalyzed Dynamic Kinetic Resolution
Atropisomeric heterobiaryl primary amines are of significant interest in both organic and pharmaceutical chemistry. A series of transaminases have been employed to synthesize these valuable compounds with high yields (up to 98% conversion) and excellent enantioselectivities (up to ≥99% ee) via dynam...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/421898 |
| Acceso en línea: | http://hdl.handle.net/10261/421898 https://api.elsevier.com/content/abstract/scopus_id/105022904595 |
| Access Level: | acceso abierto |
| Palabra clave: | Atroposelective synthesis Dynamic kinetic resolutions Selective aminations Transaminases |
| Sumario: | Atropisomeric heterobiaryl primary amines are of significant interest in both organic and pharmaceutical chemistry. A series of transaminases have been employed to synthesize these valuable compounds with high yields (up to 98% conversion) and excellent enantioselectivities (up to ≥99% ee) via dynamic kinetic resolution of the corresponding heterobiaryl aldehydes. This process features a Lewis acid–base interaction strategy to facilitate labilization of the stereogenic axis. |
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