Propagation of Tau via extracellular vesicles

Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s d...

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Autores: Pérez Martínez, María Mar, Avila, Jesús, Hernández Pérez, Félix
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/709957
Acceso en línea:http://hdl.handle.net/10486/709957
https://dx.doi.org/10.3389/fnins.2019.00698
Access Level:acceso abierto
Palabra clave:Tau propagation
extracellular vesicles
neurodegenerative disease
Tau protein
Alzheimer’s disease
Medicina
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spelling Propagation of Tau via extracellular vesiclesPérez Martínez, María MarAvila, JesúsHernández Pérez, FélixTau propagationextracellular vesiclesneurodegenerative diseaseTau proteinAlzheimer’s diseaseMedicinaExtracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease, and prion diseases. All of these disorders are characterized by protein aggregation and deposition in specific regions of the brain. Several lines of evidence indicate that protein in exosomes is released from affected neurons and propagated along neuroanatomically connected regions of the brain, thus spreading the neurodegenerative disease. Also, different cell types contribute to the progression of tauopathy, such as microglia. Several groups have reported tau release via exosomes by cultured neurons or cells overexpressing human tau. Although the exact mechanisms underlying the propagation of protein aggregates are not fully understood, recent findings have implicated EVs in this process. The AD brain has two hallmarks, namely the presence of amyloid-β-containing plaques and neurofibrillary tangles, the latter formed by hyperphosphorylated tau protein. Both amyloid peptide and tau protein are present in specific exosomes. This review summarizes recent advances in our understanding of exosomes in the pathology of AD, with a special focus on tau proteinThis study was funded by grants from Spanish Ministry of Science, Innovation and Universities (BFU2016- 77885-P), the Comunidad de Madrid, through EU structural funds (S2017/BMD-3700 NEUROMETAD-CM), CIBERNED (ISCIII), and the Fundacion Ramon ArecesFrontiers MediaDepartamento de Anatomía, Histología y NeurocienciaDepartamento de Biología MolecularFacultad de Medicina20192019-07-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/709957https://dx.doi.org/10.3389/fnins.2019.00698reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7099572026-06-23T12:46:27Z
dc.title.none.fl_str_mv Propagation of Tau via extracellular vesicles
title Propagation of Tau via extracellular vesicles
spellingShingle Propagation of Tau via extracellular vesicles
Pérez Martínez, María Mar
Tau propagation
extracellular vesicles
neurodegenerative disease
Tau protein
Alzheimer’s disease
Medicina
title_short Propagation of Tau via extracellular vesicles
title_full Propagation of Tau via extracellular vesicles
title_fullStr Propagation of Tau via extracellular vesicles
title_full_unstemmed Propagation of Tau via extracellular vesicles
title_sort Propagation of Tau via extracellular vesicles
dc.creator.none.fl_str_mv Pérez Martínez, María Mar
Avila, Jesús
Hernández Pérez, Félix
author Pérez Martínez, María Mar
author_facet Pérez Martínez, María Mar
Avila, Jesús
Hernández Pérez, Félix
author_role author
author2 Avila, Jesús
Hernández Pérez, Félix
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Anatomía, Histología y Neurociencia
Departamento de Biología Molecular
Facultad de Medicina
dc.subject.none.fl_str_mv Tau propagation
extracellular vesicles
neurodegenerative disease
Tau protein
Alzheimer’s disease
Medicina
topic Tau propagation
extracellular vesicles
neurodegenerative disease
Tau protein
Alzheimer’s disease
Medicina
description Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease, and prion diseases. All of these disorders are characterized by protein aggregation and deposition in specific regions of the brain. Several lines of evidence indicate that protein in exosomes is released from affected neurons and propagated along neuroanatomically connected regions of the brain, thus spreading the neurodegenerative disease. Also, different cell types contribute to the progression of tauopathy, such as microglia. Several groups have reported tau release via exosomes by cultured neurons or cells overexpressing human tau. Although the exact mechanisms underlying the propagation of protein aggregates are not fully understood, recent findings have implicated EVs in this process. The AD brain has two hallmarks, namely the presence of amyloid-β-containing plaques and neurofibrillary tangles, the latter formed by hyperphosphorylated tau protein. Both amyloid peptide and tau protein are present in specific exosomes. This review summarizes recent advances in our understanding of exosomes in the pathology of AD, with a special focus on tau protein
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-07-02
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/709957
https://dx.doi.org/10.3389/fnins.2019.00698
url http://hdl.handle.net/10486/709957
https://dx.doi.org/10.3389/fnins.2019.00698
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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