Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?

The frailty syndrome increases the morbidity/mortality in older adults, and several studies have shown a higher prevalence of this syndrome in patients with Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to identify the characteristics of frail patients with COPD to define a...

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Autores: Naval E, González MC, Giraldós S, Calatayud J, Jornet M, Lluch I, Meseguer M, Cubillan JJR, Viña J, Tarazona-Santabalbina FJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p13304
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/13304
Access Level:acceso abierto
Palabra clave:COPD
frailty
phenotype
COPD-frail
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spelling Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?Naval EGonzález MCGiraldós SCalatayud JJornet MLluch IMeseguer MCubillan JJRViña JTarazona-Santabalbina FJCOPDfrailtyphenotypeCOPD-frailThe frailty syndrome increases the morbidity/mortality in older adults, and several studies have shown a higher prevalence of this syndrome in patients with Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to identify the characteristics of frail patients with COPD to define a new phenotype called "COPD-frail." We conducted a cross-sectional study in a cohort of patients with stable COPD, classified as either frail, pre-frail, or non-frail. Sociodemographic, clinical, and biochemical variables were compared between the three groups of patients. The study included 127 patients, of which 31 were frail, 64 were pre-frail, and 32 non-frail. All subjects had FEV1/FVC below the lower limit of normal (range Z-score: -1.66 and -5.32). Patients in the frail group showed significantly higher scores in the mMRC (modified Medical Research Council) scale, the CAT (COPD Assessment Test), and the BODE (Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity) index. They also showed differences in symptoms according to GOLD (Global Initiative for Chronic Obstructive Lung Disease), as well as more COPD exacerbations, less physical activity, more anxiety and depression symptoms based on HADS (Hospital Anxiety and Depression Scale), and lower hemoglobin, hematocrit, and 25-hydroxycholecalciferol levels. Variables with independent association with frailty included the mMRC score, the HAD index for depression and age. In summary, differential characteristics of frail patients with COPD encourage the definition of a "COPD-frail" phenotype that-if identified early-would allow performing interventions to prevent a negative impact on the morbidity/mortality of these patients.TAYLOR & FRANCIS INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/13304COPD-Journal of Chronic Obstructive Pulmonary DiseaseISSN: 15412555ISSNe: 15412563reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p133042026-06-11T12:45:17Z
dc.title.none.fl_str_mv Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
title Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
spellingShingle Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
Naval E
COPD
frailty
phenotype
COPD-frail
title_short Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
title_full Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
title_fullStr Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
title_full_unstemmed Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
title_sort Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
dc.creator.none.fl_str_mv Naval E
González MC
Giraldós S
Calatayud J
Jornet M
Lluch I
Meseguer M
Cubillan JJR
Viña J
Tarazona-Santabalbina FJ
author Naval E
author_facet Naval E
González MC
Giraldós S
Calatayud J
Jornet M
Lluch I
Meseguer M
Cubillan JJR
Viña J
Tarazona-Santabalbina FJ
author_role author
author2 González MC
Giraldós S
Calatayud J
Jornet M
Lluch I
Meseguer M
Cubillan JJR
Viña J
Tarazona-Santabalbina FJ
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COPD
frailty
phenotype
COPD-frail
topic COPD
frailty
phenotype
COPD-frail
description The frailty syndrome increases the morbidity/mortality in older adults, and several studies have shown a higher prevalence of this syndrome in patients with Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to identify the characteristics of frail patients with COPD to define a new phenotype called "COPD-frail." We conducted a cross-sectional study in a cohort of patients with stable COPD, classified as either frail, pre-frail, or non-frail. Sociodemographic, clinical, and biochemical variables were compared between the three groups of patients. The study included 127 patients, of which 31 were frail, 64 were pre-frail, and 32 non-frail. All subjects had FEV1/FVC below the lower limit of normal (range Z-score: -1.66 and -5.32). Patients in the frail group showed significantly higher scores in the mMRC (modified Medical Research Council) scale, the CAT (COPD Assessment Test), and the BODE (Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity) index. They also showed differences in symptoms according to GOLD (Global Initiative for Chronic Obstructive Lung Disease), as well as more COPD exacerbations, less physical activity, more anxiety and depression symptoms based on HADS (Hospital Anxiety and Depression Scale), and lower hemoglobin, hematocrit, and 25-hydroxycholecalciferol levels. Variables with independent association with frailty included the mMRC score, the HAD index for depression and age. In summary, differential characteristics of frail patients with COPD encourage the definition of a "COPD-frail" phenotype that-if identified early-would allow performing interventions to prevent a negative impact on the morbidity/mortality of these patients.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/13304
url https://fisabio.portalinvestigacion.com/publicaciones/13304
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS INC
publisher.none.fl_str_mv TAYLOR & FRANCIS INC
dc.source.none.fl_str_mv COPD-Journal of Chronic Obstructive Pulmonary Disease
ISSN: 15412555
ISSNe: 15412563
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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