Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma

This article belongs to the Special Issue Tumors of the Central Nervous System: An Update.

Detalles Bibliográficos
Autores: Molina, María Luisa, García-Bernal, David, Martínez, Salvador, Valdor, Ruth
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/217684
Acceso en línea:http://hdl.handle.net/10261/217684
Access Level:acceso abierto
Palabra clave:Glioblastoma
Perivascular cells
Autophagy
Tumor
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spelling Autophagy in the immunosuppressive perivascular microenvironment of glioblastomaMolina, María LuisaGarcía-Bernal, DavidMartínez, SalvadorValdor, RuthGlioblastomaPerivascular cellsAutophagyTumorThis article belongs to the Special Issue Tumors of the Central Nervous System: An Update.Glioblastoma (GB) has been shown to up-regulate autophagy with anti- or pro-oncogenic effects. Recently, our group has shown how GB cells aberrantly up-regulate chaperone-mediated autophagy (CMA) in pericytes of peritumoral areas to modulate their immune function through cell-cell interaction and in the tumor’s own benefit. Thus, to understand GB progression, the effect that GB cells could have on autophagy of immune cells that surround the tumor needs to be deeply explored. In this review, we summarize all the latest evidence of several molecular and cellular immunosuppressive mechanisms in the perivascular tumor microenvironment. This immunosuppression has been reported to facilitate GB progression and may be differently modulated by several types of autophagy as a critical point to be considered for therapeutic interventions.This study was funded mainly by Ministerio de Economia y Competitividad de España, MINECO SAF2015-73923-JIN, Agencia Estatal de Investigación/Fondos Europeos de Desarrollo Regional/ Union Europea (AEI/FEDER/UE). It was supported in part by funds from Seneca Foundation 20840/PI/18, ISCIII/Red de Terapia Celular, TERCEL (RD16/0011/0010 and RD16/0011/0001).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)European CommissionFundación SénecaAgencia Estatal de Investigación (España)Instituto de Salud Carlos IIIMolina, Maria L. [0000-0001-9190-6948]García-Bernal, David [0000-0001-6610-8442]Martínez, Salvador [0000-0002-9320-4103]Valdor, Ruth [0000-0002-2681-0779]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/217684reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-73923-JINhttps://doi.org/10.3390/cancers12010102Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2176842026-05-22T06:33:51Z
dc.title.none.fl_str_mv Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
title Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
spellingShingle Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
Molina, María Luisa
Glioblastoma
Perivascular cells
Autophagy
Tumor
title_short Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
title_full Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
title_fullStr Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
title_full_unstemmed Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
title_sort Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
dc.creator.none.fl_str_mv Molina, María Luisa
García-Bernal, David
Martínez, Salvador
Valdor, Ruth
author Molina, María Luisa
author_facet Molina, María Luisa
García-Bernal, David
Martínez, Salvador
Valdor, Ruth
author_role author
author2 García-Bernal, David
Martínez, Salvador
Valdor, Ruth
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Fundación Séneca
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
Molina, Maria L. [0000-0001-9190-6948]
García-Bernal, David [0000-0001-6610-8442]
Martínez, Salvador [0000-0002-9320-4103]
Valdor, Ruth [0000-0002-2681-0779]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Glioblastoma
Perivascular cells
Autophagy
Tumor
topic Glioblastoma
Perivascular cells
Autophagy
Tumor
description This article belongs to the Special Issue Tumors of the Central Nervous System: An Update.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/217684
url http://hdl.handle.net/10261/217684
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-73923-JIN
https://doi.org/10.3390/cancers12010102
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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