Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial

Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve p...

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Detalles Bibliográficos
Autores: García-Lunar, Inés, Blanco, Isabel|||0000-0001-9452-3432, Fernández-Friera, Leticia, Prat-Gonzàlez, Susanna, Jordà, Paloma|||0000-0002-9236-1713, Sánchez, Javier, Pereda, Daniel, Pujadas, Sandra|||0000-0001-5232-4865, Rivas, Mercedes, Solé González, Eduard|||0000-0002-5727-9925, Vázquez, Jorge, Blázquez-Bermejo, Zorba|||0000-0001-7372-2950, García-Picart, Juan, Caravaca Perez, Pedro|||0000-0001-9362-8371, Escalera, Noemí, García-Pavía, Pablo|||0000-0002-5470-2257, Delgado-Jiménez, Juan Francisco|||0000-0002-5401-8324, Segovia, Javier|||0000-0002-4606-3416, Fuster, Valentín, Roig, Eulàlia|||0000-0002-3421-4985, Barberà i Mir, Joan Albert|||0000-0003-1469-4990, Ibañez, Borja|||0000-0002-5036-254X, García-Álvarez, Ana|||0000-0002-1718-2424
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:227751
Acceso en línea:https://ddd.uab.cat/record/227751
https://dx.doi.org/urn:doi:10.1016/j.jacbts.2020.01.009
Access Level:acceso abierto
Palabra clave:Adrenoreceptors
Imaging
Pulmonary hypertension
Treatment
β3AR, beta-3 adrenoreceptor
CCT, cardiac computed tomography
CGMP, cyclic guanosine monophosphate
CMR, cardiac magnetic resonance
CpcPH, combined pre- and post-capillary pulmonary hypertension
ECG, electrocardiography
HF, heart failure
IpcPH, isolated post-capillary pulmonary hypertension
ITT, intention to treat
LHD, left heart disease
LV, left ventricular
LVEF, left ventricular ejection fraction
NT-proBNP, N-terminal prohormone of brain natriuretic peptide
NYHA, New York Heart Association
PAP, pulmonary artery pressure
PH, pulmonary hypertension
PP, Per protocol
PVR, pulmonary vascular resistance
RV, right ventricle
Descripción
Sumario:Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; ).

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