Genetic heterogeneity in Algerian human populations

The demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and gene...

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Detalles Bibliográficos
Autores: Bekada, Asmahan, Arauna, Lara R, Deba, Tahria, Calafell i Majó, Francesc, Benhamamouch, Soraya, Comas, David, 1969-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/25688
Acceso en línea:http://hdl.handle.net/10230/25688
http://dx.doi.org/10.1371/journal.pone.0138453
Access Level:acceso abierto
Palabra clave:ADN mitocondrial -- Genètica
Berbers
Cromosoma Y
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repository_id_str
spelling Genetic heterogeneity in Algerian human populationsBekada, AsmahanArauna, Lara RDeba, TahriaCalafell i Majó, FrancescBenhamamouch, SorayaComas, David, 1969-ADN mitocondrial -- GenèticaBerbersCromosoma YThe demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.This study was supported by the Ministerio de Economía y Competitividad grant CGL2013-44351-P and by Direcció General de Recerca, Generalitat de Catalunya grant 2014SGR866.Public Library of Science (PLoS)201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25688http://dx.doi.org/10.1371/journal.pone.0138453reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS One. 2015;10(9):e138453info:eu-repo/grantAgreement/ES/1PE/CGL2013-44351© 2015 Bekada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/256882026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genetic heterogeneity in Algerian human populations
title Genetic heterogeneity in Algerian human populations
spellingShingle Genetic heterogeneity in Algerian human populations
Bekada, Asmahan
ADN mitocondrial -- Genètica
Berbers
Cromosoma Y
title_short Genetic heterogeneity in Algerian human populations
title_full Genetic heterogeneity in Algerian human populations
title_fullStr Genetic heterogeneity in Algerian human populations
title_full_unstemmed Genetic heterogeneity in Algerian human populations
title_sort Genetic heterogeneity in Algerian human populations
dc.creator.none.fl_str_mv Bekada, Asmahan
Arauna, Lara R
Deba, Tahria
Calafell i Majó, Francesc
Benhamamouch, Soraya
Comas, David, 1969-
author Bekada, Asmahan
author_facet Bekada, Asmahan
Arauna, Lara R
Deba, Tahria
Calafell i Majó, Francesc
Benhamamouch, Soraya
Comas, David, 1969-
author_role author
author2 Arauna, Lara R
Deba, Tahria
Calafell i Majó, Francesc
Benhamamouch, Soraya
Comas, David, 1969-
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ADN mitocondrial -- Genètica
Berbers
Cromosoma Y
topic ADN mitocondrial -- Genètica
Berbers
Cromosoma Y
description The demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25688
http://dx.doi.org/10.1371/journal.pone.0138453
url http://hdl.handle.net/10230/25688
http://dx.doi.org/10.1371/journal.pone.0138453
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS One. 2015;10(9):e138453
info:eu-repo/grantAgreement/ES/1PE/CGL2013-44351
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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