Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey

: This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observational cross-sectional study was conducted using an online survey, translated into four languages and disseminated to...

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Autores: Rebocho, Rita, Domínguez Ruiz, Marina, Englar, Ryane E., Arenas, Carolina, Pérez Alenza, Maria Dolores, Corsini, Andrea, Fracassi, Federico, Bennaim, Michael, Oliveira Leal, Rodolfo
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Alfonso X el Sabio
Repositorio:Repositorio Institucional de la Universidad Alfonso X el Sabio
Idioma:inglés
OAI Identifier:oai:archive.uax.com:20.500.12080/26218
Acceso en línea:https://hdl.handle.net/20.500.12080/26218
Access Level:acceso abierto
Palabra clave:hypoadrenocorticism
deoxycorticosterone pivalate
fludrocortisone
Europe
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spelling Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European SurveyRebocho, RitaDomínguez Ruiz, MarinaEnglar, Ryane E.Arenas, CarolinaPérez Alenza, Maria DoloresCorsini, AndreaFracassi, FedericoBennaim, MichaelOliveira Leal, Rodolfohypoadrenocorticismdeoxycorticosterone pivalatefludrocortisoneEurope: This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observational cross-sectional study was conducted using an online survey, translated into four languages and disseminated to veterinary affiliates and mailing lists in six countries of Western Continental Europe. Respondents were tasked to share their therapeutic approach to hypoadrenocorticism, whether they preferred DOCP or fludrocortisone and the specific practical use of DOCP. One-hundred and eighty-four responses were included. Of these, 79.9% indicated that they preferred prescribing DOCP over fludrocortisone as a first-line treatment for mineralocorticoid supplementation. A total of 154 respondents had used DOCP at least once. Eighty percent of those who reported their initial dosage prescribed 2.2 mg/kg. After starting DOCP, 68.2% of the respondents assess electrolytes 10 and 25 days after administration following manufacturer instructions. In stable dogs, electrolytes are monitored quarterly, monthly, semi-annually, and annually by 44.2%, 34.4%, 16.9%, and 4.6% of respondents respectively. When treatment adjustment is required, 53% prefer to reduce dosage while 47% increase the interval between doses. Overall, DOCP is the preferred mineralocorticoid supplementation among WEV. Reported variability underlies the need to investigate the best strategies for DOCP use and therapeutic adjustments.UAX Archive20212021-11-0920212021-11-09journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12080/26218reponame:Repositorio Institucional de la Universidad Alfonso X el Sabioinstname:Universidad Alfonso X el SabioInglésengopen accesshttp://purl.org/coar/access_right/c_abf2CC-BYhttp://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccessoai:archive.uax.com:20.500.12080/262182026-05-28T12:40:21Z
dc.title.none.fl_str_mv Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
spellingShingle Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
Rebocho, Rita
hypoadrenocorticism
deoxycorticosterone pivalate
fludrocortisone
Europe
title_short Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_full Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_fullStr Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_full_unstemmed Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_sort Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
dc.creator.none.fl_str_mv Rebocho, Rita
Domínguez Ruiz, Marina
Englar, Ryane E.
Arenas, Carolina
Pérez Alenza, Maria Dolores
Corsini, Andrea
Fracassi, Federico
Bennaim, Michael
Oliveira Leal, Rodolfo
author Rebocho, Rita
author_facet Rebocho, Rita
Domínguez Ruiz, Marina
Englar, Ryane E.
Arenas, Carolina
Pérez Alenza, Maria Dolores
Corsini, Andrea
Fracassi, Federico
Bennaim, Michael
Oliveira Leal, Rodolfo
author_role author
author2 Domínguez Ruiz, Marina
Englar, Ryane E.
Arenas, Carolina
Pérez Alenza, Maria Dolores
Corsini, Andrea
Fracassi, Federico
Bennaim, Michael
Oliveira Leal, Rodolfo
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UAX Archive
dc.subject.none.fl_str_mv hypoadrenocorticism
deoxycorticosterone pivalate
fludrocortisone
Europe
topic hypoadrenocorticism
deoxycorticosterone pivalate
fludrocortisone
Europe
description : This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observational cross-sectional study was conducted using an online survey, translated into four languages and disseminated to veterinary affiliates and mailing lists in six countries of Western Continental Europe. Respondents were tasked to share their therapeutic approach to hypoadrenocorticism, whether they preferred DOCP or fludrocortisone and the specific practical use of DOCP. One-hundred and eighty-four responses were included. Of these, 79.9% indicated that they preferred prescribing DOCP over fludrocortisone as a first-line treatment for mineralocorticoid supplementation. A total of 154 respondents had used DOCP at least once. Eighty percent of those who reported their initial dosage prescribed 2.2 mg/kg. After starting DOCP, 68.2% of the respondents assess electrolytes 10 and 25 days after administration following manufacturer instructions. In stable dogs, electrolytes are monitored quarterly, monthly, semi-annually, and annually by 44.2%, 34.4%, 16.9%, and 4.6% of respondents respectively. When treatment adjustment is required, 53% prefer to reduce dosage while 47% increase the interval between doses. Overall, DOCP is the preferred mineralocorticoid supplementation among WEV. Reported variability underlies the need to investigate the best strategies for DOCP use and therapeutic adjustments.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-11-09
2021
2021-11-09
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12080/26218
url https://hdl.handle.net/20.500.12080/26218
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
CC-BY
http://creativecommons.org/licenses/by/4.0/deed.es
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
CC-BY
http://creativecommons.org/licenses/by/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad Alfonso X el Sabio
instname:Universidad Alfonso X el Sabio
instname_str Universidad Alfonso X el Sabio
reponame_str Repositorio Institucional de la Universidad Alfonso X el Sabio
collection Repositorio Institucional de la Universidad Alfonso X el Sabio
repository.name.fl_str_mv
repository.mail.fl_str_mv
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