Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplet...

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Authors: Fages, Anne, Duarte Salles, Talita, Stepien, Magdalena, Ferrari, Pietro, Fedirko, Veronika, Pontoizeau, Clément, Trichopoulou, Antonia, Aleksandrova, Krasimira, Tjønneland, Anne, Olsen, Anja, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Kaaks, Rudolf, Kuhn, Tilman, Floegel, Anna, Boeing, Heiner, Lagiou, Pagona, Bamia, Christina, Trichopoulos, Dimitrios, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Weiderpass, Elisabete, Agudo, Antonio, Molina Montes, Esther, Huerta Castaño, José María, Ardanaz, Eva, Dorronsoro, Miren, Sjöberg, Klas, Ohlsson, Bodil, Khaw, Kay-Tee, Wareham, Nicholas J., Travis, Ruth C., Schmidt, Julie A., Cross, Amanda J., Gunter, Marc J., Riboli, Elio, Scalbert, Augustin, Romieu, Isabelle, Elena-Herrmann, Benedicte, Jenab, Mazda
Format: article
Status:Published version
Publication Date:2015
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126856
Online Access:https://hdl.handle.net/2445/126856
Access Level:Open access
Keyword:Epidemiologia
Càncer de fetge
Epidemiology
Liver cancer
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repository_id_str
spelling Metabolomic profiles of hepatocellular carcinoma in a European prospective cohortFages, AnneDuarte Salles, TalitaStepien, MagdalenaFerrari, PietroFedirko, VeronikaPontoizeau, ClémentTrichopoulou, AntoniaAleksandrova, KrasimiraTjønneland, AnneOlsen, AnjaClavel-Chapelon, FrançoiseBoutron-Ruault, Marie-ChristineSeveri, GianlucaKaaks, RudolfKuhn, TilmanFloegel, AnnaBoeing, HeinerLagiou, PagonaBamia, ChristinaTrichopoulos, DimitriosPalli, DomenicoPala, ValeriaPanico, SalvatoreTumino, RosarioVineis, PaoloBueno de Mesquita, H. BasPeeters, Petra H. M.Weiderpass, ElisabeteAgudo, AntonioMolina Montes, EstherHuerta Castaño, José MaríaArdanaz, EvaDorronsoro, MirenSjöberg, KlasOhlsson, BodilKhaw, Kay-TeeWareham, Nicholas J.Travis, Ruth C.Schmidt, Julie A.Cross, Amanda J.Gunter, Marc J.Riboli, ElioScalbert, AugustinRomieu, IsabelleElena-Herrmann, BenedicteJenab, MazdaEpidemiologiaCàncer de fetgeEpidemiologyLiver cancerBackground: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer.BioMed Central2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126856Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s12916-015-0462-9BMC Medicine, 2015, vol. 13, num. 242https://doi.org/10.1186/s12916-015-0462-9info:eu-repo/grantAgreement/EC/FP7/232997cc by (c) Fages et al., 2015http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1268562026-05-27T06:46:51Z
dc.title.none.fl_str_mv Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
title Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
spellingShingle Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
Fages, Anne
Epidemiologia
Càncer de fetge
Epidemiology
Liver cancer
title_short Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
title_full Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
title_fullStr Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
title_full_unstemmed Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
title_sort Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
dc.creator.none.fl_str_mv Fages, Anne
Duarte Salles, Talita
Stepien, Magdalena
Ferrari, Pietro
Fedirko, Veronika
Pontoizeau, Clément
Trichopoulou, Antonia
Aleksandrova, Krasimira
Tjønneland, Anne
Olsen, Anja
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Kaaks, Rudolf
Kuhn, Tilman
Floegel, Anna
Boeing, Heiner
Lagiou, Pagona
Bamia, Christina
Trichopoulos, Dimitrios
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Bueno de Mesquita, H. Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Agudo, Antonio
Molina Montes, Esther
Huerta Castaño, José María
Ardanaz, Eva
Dorronsoro, Miren
Sjöberg, Klas
Ohlsson, Bodil
Khaw, Kay-Tee
Wareham, Nicholas J.
Travis, Ruth C.
Schmidt, Julie A.
Cross, Amanda J.
Gunter, Marc J.
Riboli, Elio
Scalbert, Augustin
Romieu, Isabelle
Elena-Herrmann, Benedicte
Jenab, Mazda
author Fages, Anne
author_facet Fages, Anne
Duarte Salles, Talita
Stepien, Magdalena
Ferrari, Pietro
Fedirko, Veronika
Pontoizeau, Clément
Trichopoulou, Antonia
Aleksandrova, Krasimira
Tjønneland, Anne
Olsen, Anja
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Kaaks, Rudolf
Kuhn, Tilman
Floegel, Anna
Boeing, Heiner
Lagiou, Pagona
Bamia, Christina
Trichopoulos, Dimitrios
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Bueno de Mesquita, H. Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Agudo, Antonio
Molina Montes, Esther
Huerta Castaño, José María
Ardanaz, Eva
Dorronsoro, Miren
Sjöberg, Klas
Ohlsson, Bodil
Khaw, Kay-Tee
Wareham, Nicholas J.
Travis, Ruth C.
Schmidt, Julie A.
Cross, Amanda J.
Gunter, Marc J.
Riboli, Elio
Scalbert, Augustin
Romieu, Isabelle
Elena-Herrmann, Benedicte
Jenab, Mazda
author_role author
author2 Duarte Salles, Talita
Stepien, Magdalena
Ferrari, Pietro
Fedirko, Veronika
Pontoizeau, Clément
Trichopoulou, Antonia
Aleksandrova, Krasimira
Tjønneland, Anne
Olsen, Anja
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Kaaks, Rudolf
Kuhn, Tilman
Floegel, Anna
Boeing, Heiner
Lagiou, Pagona
Bamia, Christina
Trichopoulos, Dimitrios
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Bueno de Mesquita, H. Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Agudo, Antonio
Molina Montes, Esther
Huerta Castaño, José María
Ardanaz, Eva
Dorronsoro, Miren
Sjöberg, Klas
Ohlsson, Bodil
Khaw, Kay-Tee
Wareham, Nicholas J.
Travis, Ruth C.
Schmidt, Julie A.
Cross, Amanda J.
Gunter, Marc J.
Riboli, Elio
Scalbert, Augustin
Romieu, Isabelle
Elena-Herrmann, Benedicte
Jenab, Mazda
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epidemiologia
Càncer de fetge
Epidemiology
Liver cancer
topic Epidemiologia
Càncer de fetge
Epidemiology
Liver cancer
description Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126856
url https://hdl.handle.net/2445/126856
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12916-015-0462-9
BMC Medicine, 2015, vol. 13, num. 242
https://doi.org/10.1186/s12916-015-0462-9
info:eu-repo/grantAgreement/EC/FP7/232997
dc.rights.none.fl_str_mv cc by (c) Fages et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Fages et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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