Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Harewood, Rhea; Rothwell, Joseph A.; Bešević, Jelena; Viallon, Vivian; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Wedekind, Roland; Prehn, Cornelia; Adamski, Jerzy; Schmidt, Julie A.; Jacobs, Inarie; Tjønneland, Anne; Olsen, Anja; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena Andrea; Schulze, Matthias B.; Prada, Marcela; Masala, Giovanna; Agnoli, Claudia; Panico, Salvatore; Sacerdote, Carlotta; Jakszyn, Paula; Sánchez, María-José; Castilla, Jesús; Chirlaque, Maria-Dolores; Aizpurua Atxega, Amaia; Van Guelpen, Bethany; Heath, Alicia K.; Papier, Keren; Tong, Tammy Y. N.; Summers, Scott A.; Playdon, Mary; Cross, Amanda J.; Keski-Rahkonen, Pekka; Chajès, Véronique; Murphy, Neil; Gunter, Marc J.

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined a...

Descripción completa

Detalles Bibliográficos
Autores:	Harewood, Rhea, Rothwell, Joseph A., Bešević, Jelena, Viallon, Vivian, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Wedekind, Roland, Prehn, Cornelia, Adamski, Jerzy, Schmidt, Julie A., Jacobs, Inarie, Tjønneland, Anne, Olsen, Anja, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena Andrea, Schulze, Matthias B., Prada, Marcela, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Sacerdote, Carlotta, Jakszyn, Paula, Sánchez, María-José, Castilla, Jesús, Chirlaque, Maria-Dolores, Aizpurua Atxega, Amaia, Van Guelpen, Bethany, Heath, Alicia K., Papier, Keren, Tong, Tammy Y. N., Summers, Scott A., Playdon, Mary, Cross, Amanda J., Keski-Rahkonen, Pekka, Chajès, Véronique, Murphy, Neil, Gunter, Marc J.
Tipo de recurso:	artículo
Fecha de publicación:	2024
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:20.500.14342/5055
Acceso en línea:	http://hdl.handle.net/20.500.14342/5055 https://doi.org/10.1016/j.ebiom.2024.105024
Access Level:	acceso abierto
Palabra clave:	Còlon -- Càncer Metabolòmica Lípids Glicerofosfolípids Esfingolípids Acilcarnitines

id	ES_01ac0a1bd51d0a7423af46c4fb47792c
oai_identifier_str	oai:recercat.cat:20.500.14342/5055
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)Harewood, RheaRothwell, Joseph A.Bešević, JelenaViallon, VivianAchaintre, DavidGicquiau, AudreyRinaldi, SabinaWedekind, RolandPrehn, CorneliaAdamski, JerzySchmidt, Julie A.Jacobs, InarieTjønneland, AnneOlsen, AnjaSeveri, GianlucaKaaks, RudolfKatzke, Verena AndreaSchulze, Matthias B.Prada, MarcelaMasala, GiovannaAgnoli, ClaudiaPanico, SalvatoreSacerdote, CarlottaJakszyn, PaulaSánchez, María-JoséCastilla, JesúsChirlaque, Maria-DoloresAizpurua Atxega, AmaiaVan Guelpen, BethanyHeath, Alicia K.Papier, KerenTong, Tammy Y. N.Summers, Scott A.Playdon, MaryCross, Amanda J.Keski-Rahkonen, PekkaChajès, VéroniqueMurphy, NeilGunter, Marc J.Còlon -- CàncerMetabolòmicaLípidsGlicerofosfolípidsEsfingolípidsAcilcarnitinesBackground Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. Findings Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (ORper doubling 0.60, 95% CI 0.47–0.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (ORper doubling 0.71, 95% CI 0.59–0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer. Interpretation Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations.info:eu-repo/semantics/publishedVersionElsevierUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2024info:eu-repo/semantics/article15 p.http://hdl.handle.net/20.500.14342/5055https://doi.org/10.1016/j.ebiom.2024.105024reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)IngléseBioMedicine, 2024, 101: 105024© L'autor/aAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/50552026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
title	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
spellingShingle	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) Harewood, Rhea Còlon -- Càncer Metabolòmica Lípids Glicerofosfolípids Esfingolípids Acilcarnitines
title_short	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_full	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_fullStr	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_full_unstemmed	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_sort	Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
dc.creator.none.fl_str_mv	Harewood, Rhea Rothwell, Joseph A. Bešević, Jelena Viallon, Vivian Achaintre, David Gicquiau, Audrey Rinaldi, Sabina Wedekind, Roland Prehn, Cornelia Adamski, Jerzy Schmidt, Julie A. Jacobs, Inarie Tjønneland, Anne Olsen, Anja Severi, Gianluca Kaaks, Rudolf Katzke, Verena Andrea Schulze, Matthias B. Prada, Marcela Masala, Giovanna Agnoli, Claudia Panico, Salvatore Sacerdote, Carlotta Jakszyn, Paula Sánchez, María-José Castilla, Jesús Chirlaque, Maria-Dolores Aizpurua Atxega, Amaia Van Guelpen, Bethany Heath, Alicia K. Papier, Keren Tong, Tammy Y. N. Summers, Scott A. Playdon, Mary Cross, Amanda J. Keski-Rahkonen, Pekka Chajès, Véronique Murphy, Neil Gunter, Marc J.
author	Harewood, Rhea
author_facet	Harewood, Rhea Rothwell, Joseph A. Bešević, Jelena Viallon, Vivian Achaintre, David Gicquiau, Audrey Rinaldi, Sabina Wedekind, Roland Prehn, Cornelia Adamski, Jerzy Schmidt, Julie A. Jacobs, Inarie Tjønneland, Anne Olsen, Anja Severi, Gianluca Kaaks, Rudolf Katzke, Verena Andrea Schulze, Matthias B. Prada, Marcela Masala, Giovanna Agnoli, Claudia Panico, Salvatore Sacerdote, Carlotta Jakszyn, Paula Sánchez, María-José Castilla, Jesús Chirlaque, Maria-Dolores Aizpurua Atxega, Amaia Van Guelpen, Bethany Heath, Alicia K. Papier, Keren Tong, Tammy Y. N. Summers, Scott A. Playdon, Mary Cross, Amanda J. Keski-Rahkonen, Pekka Chajès, Véronique Murphy, Neil Gunter, Marc J.
author_role	author
author2	Rothwell, Joseph A. Bešević, Jelena Viallon, Vivian Achaintre, David Gicquiau, Audrey Rinaldi, Sabina Wedekind, Roland Prehn, Cornelia Adamski, Jerzy Schmidt, Julie A. Jacobs, Inarie Tjønneland, Anne Olsen, Anja Severi, Gianluca Kaaks, Rudolf Katzke, Verena Andrea Schulze, Matthias B. Prada, Marcela Masala, Giovanna Agnoli, Claudia Panico, Salvatore Sacerdote, Carlotta Jakszyn, Paula Sánchez, María-José Castilla, Jesús Chirlaque, Maria-Dolores Aizpurua Atxega, Amaia Van Guelpen, Bethany Heath, Alicia K. Papier, Keren Tong, Tammy Y. N. Summers, Scott A. Playdon, Mary Cross, Amanda J. Keski-Rahkonen, Pekka Chajès, Véronique Murphy, Neil Gunter, Marc J.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv	Còlon -- Càncer Metabolòmica Lípids Glicerofosfolípids Esfingolípids Acilcarnitines
topic	Còlon -- Càncer Metabolòmica Lípids Glicerofosfolípids Esfingolípids Acilcarnitines
description	Background Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. Findings Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (ORper doubling 0.60, 95% CI 0.47–0.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (ORper doubling 0.71, 95% CI 0.59–0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer. Interpretation Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations.
publishDate	2024
dc.date.none.fl_str_mv	2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.14342/5055 https://doi.org/10.1016/j.ebiom.2024.105024
url	http://hdl.handle.net/20.500.14342/5055 https://doi.org/10.1016/j.ebiom.2024.105024
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	eBioMedicine, 2024, 101: 105024
dc.rights.none.fl_str_mv	© L'autor/a Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	© L'autor/a Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	15 p.
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869402600525266944
score	15,811543

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Similares en LA Referencia