Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2

In the context of ongoing and future pandemics, non-pharmaceutical interventions are critical in reducing viral infections and the emergence of new antigenic variants while the population reaches immunity to limit viral transmission. This study provides information on efficient and fast methods of d...

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Autores: Bello-Pérez, Melissa, Esparza, Iris, De la Encina, Arancha, Bartolome, Teresa, Puig Molina, Teresa, Sanjuan, Elena, Falcó, Alberto, Enjuanes Sánchez, Luis, Solá Gurpegui, Isabel, Usera, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/307677
Acceso en línea:http://hdl.handle.net/10261/307677
https://api.elsevier.com/content/abstract/scopus_id/85141584004
Access Level:acceso abierto
Palabra clave:HCoV-229E
MERS-CoV
SARS-CoV-2
Coronavirus
Pulsed-xenon ultraviolet
Virus inactivation
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spelling Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2Bello-Pérez, MelissaEsparza, IrisDe la Encina, AranchaBartolome, TeresaPuig Molina, TeresaSanjuan, ElenaFalcó, AlbertoEnjuanes Sánchez, LuisSolá Gurpegui, IsabelUsera, FernandoHCoV-229EMERS-CoVSARS-CoV-2CoronavirusPulsed-xenon ultravioletVirus inactivationIn the context of ongoing and future pandemics, non-pharmaceutical interventions are critical in reducing viral infections and the emergence of new antigenic variants while the population reaches immunity to limit viral transmission. This study provides information on efficient and fast methods of disinfecting surfaces contaminated with different human coronaviruses (CoVs) in healthcare settings. The ability to disinfect three different human coronaviruses (HCoV-229E, MERS-CoV, and SARS-CoV-2) on dried surfaces with light was determined for a fully characterized pulsed-xenon ultraviolet (PX-UV) source. Thereafter, the effectiveness of this treatment to inactivate SARS-CoV-2 was compared to that of conventional low-pressure mercury UVC lamps by using equivalent irradiances of UVC wavelengths. Under the experimental conditions of this research, PX-UV light completely inactivated the CoVs tested on solid surfaces since the infectivity of the three CoVs was reduced up to 4 orders of magnitude by PX-UV irradiation, with a cumulated dose of as much as 21.162 mJ/cm2 when considering all UV wavelengths (5.402 mJ/cm2 of just UVC light). Furthermore, continuous irradiation with UVC light was less efficient in inactivating SARS-CoV-2 than treatment with PX-UV light. Therefore, PX-UV light postulates as a promising decontamination measure to tackle the propagation of future outbreaks of CoVs.This research was funded by a contract between the National Centre for Biotechnology and CLECE, S.A.Peer reviewedMolecular Diversity Preservation InternationalCSIC - Centro Nacional de Biotecnología (CNB)CleceBello-Perez, Melissa [0000-0002-9212-083XFalco, Alberto [0000-0001-7726-6577]Enjuanes Sánchez, Luis [0000-0002-0854-0226]Solá Gurpegui, Isabel [0000-0002-5704-1917]+Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/307677https://api.elsevier.com/content/abstract/scopus_id/85141584004reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational journal of environmental research and public healthhttps://doi.org/10.3390/ijerph192113780Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3076772026-05-22T06:33:51Z
dc.title.none.fl_str_mv Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
title Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
spellingShingle Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
Bello-Pérez, Melissa
HCoV-229E
MERS-CoV
SARS-CoV-2
Coronavirus
Pulsed-xenon ultraviolet
Virus inactivation
title_short Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
title_full Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
title_fullStr Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
title_full_unstemmed Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
title_sort Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
dc.creator.none.fl_str_mv Bello-Pérez, Melissa
Esparza, Iris
De la Encina, Arancha
Bartolome, Teresa
Puig Molina, Teresa
Sanjuan, Elena
Falcó, Alberto
Enjuanes Sánchez, Luis
Solá Gurpegui, Isabel
Usera, Fernando
author Bello-Pérez, Melissa
author_facet Bello-Pérez, Melissa
Esparza, Iris
De la Encina, Arancha
Bartolome, Teresa
Puig Molina, Teresa
Sanjuan, Elena
Falcó, Alberto
Enjuanes Sánchez, Luis
Solá Gurpegui, Isabel
Usera, Fernando
author_role author
author2 Esparza, Iris
De la Encina, Arancha
Bartolome, Teresa
Puig Molina, Teresa
Sanjuan, Elena
Falcó, Alberto
Enjuanes Sánchez, Luis
Solá Gurpegui, Isabel
Usera, Fernando
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv CSIC - Centro Nacional de Biotecnología (CNB)
Clece
Bello-Perez, Melissa [0000-0002-9212-083X
Falco, Alberto [0000-0001-7726-6577]
Enjuanes Sánchez, Luis [0000-0002-0854-0226]
Solá Gurpegui, Isabel [0000-0002-5704-1917]+
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv HCoV-229E
MERS-CoV
SARS-CoV-2
Coronavirus
Pulsed-xenon ultraviolet
Virus inactivation
topic HCoV-229E
MERS-CoV
SARS-CoV-2
Coronavirus
Pulsed-xenon ultraviolet
Virus inactivation
description In the context of ongoing and future pandemics, non-pharmaceutical interventions are critical in reducing viral infections and the emergence of new antigenic variants while the population reaches immunity to limit viral transmission. This study provides information on efficient and fast methods of disinfecting surfaces contaminated with different human coronaviruses (CoVs) in healthcare settings. The ability to disinfect three different human coronaviruses (HCoV-229E, MERS-CoV, and SARS-CoV-2) on dried surfaces with light was determined for a fully characterized pulsed-xenon ultraviolet (PX-UV) source. Thereafter, the effectiveness of this treatment to inactivate SARS-CoV-2 was compared to that of conventional low-pressure mercury UVC lamps by using equivalent irradiances of UVC wavelengths. Under the experimental conditions of this research, PX-UV light completely inactivated the CoVs tested on solid surfaces since the infectivity of the three CoVs was reduced up to 4 orders of magnitude by PX-UV irradiation, with a cumulated dose of as much as 21.162 mJ/cm2 when considering all UV wavelengths (5.402 mJ/cm2 of just UVC light). Furthermore, continuous irradiation with UVC light was less efficient in inactivating SARS-CoV-2 than treatment with PX-UV light. Therefore, PX-UV light postulates as a promising decontamination measure to tackle the propagation of future outbreaks of CoVs.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/307677
https://api.elsevier.com/content/abstract/scopus_id/85141584004
url http://hdl.handle.net/10261/307677
https://api.elsevier.com/content/abstract/scopus_id/85141584004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of environmental research and public health
https://doi.org/10.3390/ijerph192113780
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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