Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates

In order to improve the efficiency of the anti-inflammatory drug ibuprofen, cationic carbosilanedendrimers and dendrons with ibuprofen at their periphery or at their focal point, respectively, havebeen synthesized and the release of the drug was studied using HPLC. Macrophages were used toevaluate t...

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Detalhes bibliográficos
Autores: Perise-Barrios, A.J., Fuentes Paniagua, María Elena, Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285, Serramía Lobera, María Jesús, Alonso, Ester, Reguera, Rosa, Gómez Ramírez, Rafael|||0000-0001-6448-2414, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935, Muñoz Fernández, María Ángeles
Tipo de documento: artigo
Data de publicação:2016
País:España
Recursos:Universidad de Alcalá (UAH)
Repositório:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglês
OAI Identifier:oai:ebuah.uah.es:10017/34041
Acesso em linha:http://hdl.handle.net/10017/34041
https://dx.doi.org/10.1021/acs.molpharmaceut.6b00420
Access Level:Acceso aberto
Palavra-chave:Anti-inflammatory
Carbosilane dendrimers,
Dendrons
Ibuprofen
Drug release and macrophages.
Química
Chemistry
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repository_id_str
spelling Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugatesPerise-Barrios, A.J.Fuentes Paniagua, María ElenaSánchez-Nieves Fernández, Javier|||0000-0003-0410-2285Serramía Lobera, María JesúsAlonso, EsterReguera, RosaGómez Ramírez, Rafael|||0000-0001-6448-2414Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935Muñoz Fernández, María ÁngelesAnti-inflammatoryCarbosilane dendrimers,DendronsIbuprofenDrug release and macrophages.QuímicaChemistryIn order to improve the efficiency of the anti-inflammatory drug ibuprofen, cationic carbosilanedendrimers and dendrons with ibuprofen at their periphery or at their focal point, respectively, havebeen synthesized and the release of the drug was studied using HPLC. Macrophages were used toevaluate the anti-inflammatory effect of the ibuprofen-conjugated dendritic systems and comparedwith mixtures of non-ibuprofen dendritic systems in the presence of the drug. The cationic ibuprofenconjugateddendron was the compound that showed higher anti-inflammatory properties. It reduces the LPS-induced COX-2 expression, decreases the release of several inflammatory cytokines such as TNFalfa, IL-1beta, IL-6 and CCL3. These results open new perspectives in the use of these compounds asdrug carriers.Ministerio de Economía y EmpresaAmerican Chemical Society20162016-08-17journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/34041https://dx.doi.org/10.1021/acs.molpharmaceut.6b00420reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ-2014-54004-P DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓNopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/340412026-06-18T11:13:07Z
dc.title.none.fl_str_mv Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
title Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
spellingShingle Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
Perise-Barrios, A.J.
Anti-inflammatory
Carbosilane dendrimers,
Dendrons
Ibuprofen
Drug release and macrophages.
Química
Chemistry
title_short Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
title_full Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
title_fullStr Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
title_full_unstemmed Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
title_sort Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
dc.creator.none.fl_str_mv Perise-Barrios, A.J.
Fuentes Paniagua, María Elena
Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285
Serramía Lobera, María Jesús
Alonso, Ester
Reguera, Rosa
Gómez Ramírez, Rafael|||0000-0001-6448-2414
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Muñoz Fernández, María Ángeles
author Perise-Barrios, A.J.
author_facet Perise-Barrios, A.J.
Fuentes Paniagua, María Elena
Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285
Serramía Lobera, María Jesús
Alonso, Ester
Reguera, Rosa
Gómez Ramírez, Rafael|||0000-0001-6448-2414
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Muñoz Fernández, María Ángeles
author_role author
author2 Fuentes Paniagua, María Elena
Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285
Serramía Lobera, María Jesús
Alonso, Ester
Reguera, Rosa
Gómez Ramírez, Rafael|||0000-0001-6448-2414
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Muñoz Fernández, María Ángeles
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anti-inflammatory
Carbosilane dendrimers,
Dendrons
Ibuprofen
Drug release and macrophages.
Química
Chemistry
topic Anti-inflammatory
Carbosilane dendrimers,
Dendrons
Ibuprofen
Drug release and macrophages.
Química
Chemistry
description In order to improve the efficiency of the anti-inflammatory drug ibuprofen, cationic carbosilanedendrimers and dendrons with ibuprofen at their periphery or at their focal point, respectively, havebeen synthesized and the release of the drug was studied using HPLC. Macrophages were used toevaluate the anti-inflammatory effect of the ibuprofen-conjugated dendritic systems and comparedwith mixtures of non-ibuprofen dendritic systems in the presence of the drug. The cationic ibuprofenconjugateddendron was the compound that showed higher anti-inflammatory properties. It reduces the LPS-induced COX-2 expression, decreases the release of several inflammatory cytokines such as TNFalfa, IL-1beta, IL-6 and CCL3. These results open new perspectives in the use of these compounds asdrug carriers.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-08-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/34041
https://dx.doi.org/10.1021/acs.molpharmaceut.6b00420
url http://hdl.handle.net/10017/34041
https://dx.doi.org/10.1021/acs.molpharmaceut.6b00420
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ-2014-54004-P DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓN
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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