Adverse Drug Reactions in Pediatric Oncohematology

Introduction: Adverse drug reactions (ADR) are an important cause of morbidity and mortality in pediatric patients. Due to the disease severity and chemotherapy safety profile, oncologic patients are at higher risk of ADR. However, there is little evidence on pharmacovigilance studies evaluating dru...

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Autores: Amaro-Hosey, Kristopher|||0000-0003-3801-1568, Danés Carreras, Immaculada|||0000-0002-8711-9666, Agustí Escasany, M. Antònia|||0000-0003-4594-1122
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:256082
Acesso em linha:https://ddd.uab.cat/record/256082
https://dx.doi.org/urn:doi:10.3389/fphar.2021.777498
Access Level:Acceso aberto
Palavra-chave:Pharmacovigilance
Adverse drug reactions
Pediatrics
Hematology
Oncology
Neoplasms
Systematic review
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spelling Adverse Drug Reactions in Pediatric OncohematologyA Systematic ReviewAmaro-Hosey, Kristopher|||0000-0003-3801-1568Danés Carreras, Immaculada|||0000-0002-8711-9666Agustí Escasany, M. Antònia|||0000-0003-4594-1122PharmacovigilanceAdverse drug reactionsPediatricsHematologyOncologyNeoplasmsSystematic reviewIntroduction: Adverse drug reactions (ADR) are an important cause of morbidity and mortality in pediatric patients. Due to the disease severity and chemotherapy safety profile, oncologic patients are at higher risk of ADR. However, there is little evidence on pharmacovigilance studies evaluating drug safety in this specific population. Methods: In order to assess the incidence and characteristics of ADR in pediatric patients with oncohematogical diseases and the methodology used in the studies, a systematic review was carried out using both free search and a combination of MeSH terms. Data extraction and critical appraisal were performed independently using a predefined form. Results: Fourteen studies were included, of which eight were prospective and half focused in inpatients. Sample size and study duration varied widely. Different methods of ADR identification were detected, used alone or combined. Causality and severity were assessed frequently, whereas preventability was lacking in most studies. ADR incidence varied between 14.4 and 67% in inpatients, and 19.6-68.1% in admissions, mainly in the form of hematological, gastrointestinal and skin toxicity. Between 11 and 16.4% ADR were considered severe, and preventability ranged from 0 to 74.5%. Conclusion: ADR in oncohematology pediatric patients are frequent. A high variability in study design and results has been found. The use of methodological standards and preventability assessment should be reinforced in order to allow results comparison between studies and centers, and to detected areas of improvement. Systematic Review Registration: , identifier CRD42018096513. 22022-01-0120222022-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256082https://dx.doi.org/urn:doi:10.3389/fphar.2021.777498reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2560822026-06-06T12:50:31Z
dc.title.none.fl_str_mv Adverse Drug Reactions in Pediatric Oncohematology
A Systematic Review
title Adverse Drug Reactions in Pediatric Oncohematology
spellingShingle Adverse Drug Reactions in Pediatric Oncohematology
Amaro-Hosey, Kristopher|||0000-0003-3801-1568
Pharmacovigilance
Adverse drug reactions
Pediatrics
Hematology
Oncology
Neoplasms
Systematic review
title_short Adverse Drug Reactions in Pediatric Oncohematology
title_full Adverse Drug Reactions in Pediatric Oncohematology
title_fullStr Adverse Drug Reactions in Pediatric Oncohematology
title_full_unstemmed Adverse Drug Reactions in Pediatric Oncohematology
title_sort Adverse Drug Reactions in Pediatric Oncohematology
dc.creator.none.fl_str_mv Amaro-Hosey, Kristopher|||0000-0003-3801-1568
Danés Carreras, Immaculada|||0000-0002-8711-9666
Agustí Escasany, M. Antònia|||0000-0003-4594-1122
author Amaro-Hosey, Kristopher|||0000-0003-3801-1568
author_facet Amaro-Hosey, Kristopher|||0000-0003-3801-1568
Danés Carreras, Immaculada|||0000-0002-8711-9666
Agustí Escasany, M. Antònia|||0000-0003-4594-1122
author_role author
author2 Danés Carreras, Immaculada|||0000-0002-8711-9666
Agustí Escasany, M. Antònia|||0000-0003-4594-1122
author2_role author
author
dc.subject.none.fl_str_mv Pharmacovigilance
Adverse drug reactions
Pediatrics
Hematology
Oncology
Neoplasms
Systematic review
topic Pharmacovigilance
Adverse drug reactions
Pediatrics
Hematology
Oncology
Neoplasms
Systematic review
description Introduction: Adverse drug reactions (ADR) are an important cause of morbidity and mortality in pediatric patients. Due to the disease severity and chemotherapy safety profile, oncologic patients are at higher risk of ADR. However, there is little evidence on pharmacovigilance studies evaluating drug safety in this specific population. Methods: In order to assess the incidence and characteristics of ADR in pediatric patients with oncohematogical diseases and the methodology used in the studies, a systematic review was carried out using both free search and a combination of MeSH terms. Data extraction and critical appraisal were performed independently using a predefined form. Results: Fourteen studies were included, of which eight were prospective and half focused in inpatients. Sample size and study duration varied widely. Different methods of ADR identification were detected, used alone or combined. Causality and severity were assessed frequently, whereas preventability was lacking in most studies. ADR incidence varied between 14.4 and 67% in inpatients, and 19.6-68.1% in admissions, mainly in the form of hematological, gastrointestinal and skin toxicity. Between 11 and 16.4% ADR were considered severe, and preventability ranged from 0 to 74.5%. Conclusion: ADR in oncohematology pediatric patients are frequent. A high variability in study design and results has been found. The use of methodological standards and preventability assessment should be reinforced in order to allow results comparison between studies and centers, and to detected areas of improvement. Systematic Review Registration: , identifier CRD42018096513.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
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https://dx.doi.org/urn:doi:10.3389/fphar.2021.777498
url https://ddd.uab.cat/record/256082
https://dx.doi.org/urn:doi:10.3389/fphar.2021.777498
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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