Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk

Background: Patients with Cushing’s disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors. Methods: Twenty-eight female non-diabetic patients with CD in remission with...

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Autores: Valassi, Elena, Chaysavanh, Manichanh, Amodru, Vincent, González Fernández, Pedro, Gaztambide, Sonia, Yañez, Francisca, Martel Duguech, Luciana, Puig Domingo, Manuel, Webb, Susan
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3819
Acceso en línea:http://hdl.handle.net/20.500.12328/3819
https://dx.doi.org/10.3389/fendo.2023.1074757
Access Level:acceso abierto
Palabra clave:Malaltia de Cushing
Microbiota
Risc cardiovascular
Triglicèrids
Fibrinogen
Enfermedad de Cushing
Riesgo cardiovascular
Triglicéridos
Fibrinógeno
Cushing's disease
Cardiovascular risk
Triglycerides
61
616.3
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spelling Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic riskValassi, ElenaChaysavanh, ManichanhAmodru, VincentGonzález Fernández, PedroGaztambide, SoniaYañez, FranciscaMartel Duguech, LucianaPuig Domingo, ManuelWebb, SusanMalaltia de CushingMicrobiotaRisc cardiovascularTriglicèridsFibrinogenEnfermedad de CushingMicrobiotaRiesgo cardiovascularTriglicéridosFibrinógenoCushing's diseaseMicrobiotaCardiovascular riskTriglyceridesFibrinogen61616.3Background: Patients with Cushing’s disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors. Methods: Twenty-eight female non-diabetic patients with CD in remission with a mean ± SD) age of 51 ± 9 years, mean ( ± SD) BMI, 26 ± 4, median (IQR) duration of remission, 11(4) years and 24 gender-, age, BMI–matched controls were included. The V4 region of the bacterial 16S rDNA was PCR amplified and sequenced to analyse microbial alpha diversity (Chao 1 index, observed number of species, Shannon index) and beta diversity analysis through the Principal Coordinates Analysis (PCoA) of weighted and unweighted UniFrac distances. Inter-group difference in microbiome composition was analysed using MaAsLin2. Results: The Chao 1 index was lower in CD as compared with controls (Kruskal-Wallis test, q = 0.002), indicating lower microbial richness in the former. Beta diversity analysis showed that faecal samples from CS patients clustered together and separated from the controls (Adonis test, p<0.05). Collinsella, a genus form of the Actinobacteria phylum was present in CD patients only, whereas Sutterella, a genus from Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as Lachnospira, a genus of the Lachnospiraceae family of the Firmicutes phylum. In CS, the Chao 1 index was associated with fibrinogen levels and inversely correlated with both triglyceride concentrations and the HOMA-IR index (p<0.05). Conclusions: Patients with CS in remission have gut microbial dysbiosis which may be one of the mechanisms whereby cardiometabolic dysfunctions persist after “cure”.info:eu-repo/semantics/publishedVersionFrontiers Media2023info:eu-repo/semantics/article10http://hdl.handle.net/20.500.12328/3819https://dx.doi.org/10.3389/fendo.2023.1074757reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Endocrinology14© 2023 Valassi, Manichanh, Amodru, Fernández, Gaztambide, Yañez, Martel-Duguech, Puig-Domingo and Webb. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/38192026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
title Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
spellingShingle Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
Valassi, Elena
Malaltia de Cushing
Microbiota
Risc cardiovascular
Triglicèrids
Fibrinogen
Enfermedad de Cushing
Microbiota
Riesgo cardiovascular
Triglicéridos
Fibrinógeno
Cushing's disease
Microbiota
Cardiovascular risk
Triglycerides
Fibrinogen
61
616.3
title_short Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
title_full Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
title_fullStr Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
title_full_unstemmed Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
title_sort Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
dc.creator.none.fl_str_mv Valassi, Elena
Chaysavanh, Manichanh
Amodru, Vincent
González Fernández, Pedro
Gaztambide, Sonia
Yañez, Francisca
Martel Duguech, Luciana
Puig Domingo, Manuel
Webb, Susan
author Valassi, Elena
author_facet Valassi, Elena
Chaysavanh, Manichanh
Amodru, Vincent
González Fernández, Pedro
Gaztambide, Sonia
Yañez, Francisca
Martel Duguech, Luciana
Puig Domingo, Manuel
Webb, Susan
author_role author
author2 Chaysavanh, Manichanh
Amodru, Vincent
González Fernández, Pedro
Gaztambide, Sonia
Yañez, Francisca
Martel Duguech, Luciana
Puig Domingo, Manuel
Webb, Susan
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Cushing
Microbiota
Risc cardiovascular
Triglicèrids
Fibrinogen
Enfermedad de Cushing
Microbiota
Riesgo cardiovascular
Triglicéridos
Fibrinógeno
Cushing's disease
Microbiota
Cardiovascular risk
Triglycerides
Fibrinogen
61
616.3
topic Malaltia de Cushing
Microbiota
Risc cardiovascular
Triglicèrids
Fibrinogen
Enfermedad de Cushing
Microbiota
Riesgo cardiovascular
Triglicéridos
Fibrinógeno
Cushing's disease
Microbiota
Cardiovascular risk
Triglycerides
Fibrinogen
61
616.3
description Background: Patients with Cushing’s disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors. Methods: Twenty-eight female non-diabetic patients with CD in remission with a mean ± SD) age of 51 ± 9 years, mean ( ± SD) BMI, 26 ± 4, median (IQR) duration of remission, 11(4) years and 24 gender-, age, BMI–matched controls were included. The V4 region of the bacterial 16S rDNA was PCR amplified and sequenced to analyse microbial alpha diversity (Chao 1 index, observed number of species, Shannon index) and beta diversity analysis through the Principal Coordinates Analysis (PCoA) of weighted and unweighted UniFrac distances. Inter-group difference in microbiome composition was analysed using MaAsLin2. Results: The Chao 1 index was lower in CD as compared with controls (Kruskal-Wallis test, q = 0.002), indicating lower microbial richness in the former. Beta diversity analysis showed that faecal samples from CS patients clustered together and separated from the controls (Adonis test, p<0.05). Collinsella, a genus form of the Actinobacteria phylum was present in CD patients only, whereas Sutterella, a genus from Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as Lachnospira, a genus of the Lachnospiraceae family of the Firmicutes phylum. In CS, the Chao 1 index was associated with fibrinogen levels and inversely correlated with both triglyceride concentrations and the HOMA-IR index (p<0.05). Conclusions: Patients with CS in remission have gut microbial dysbiosis which may be one of the mechanisms whereby cardiometabolic dysfunctions persist after “cure”.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3819
https://dx.doi.org/10.3389/fendo.2023.1074757
url http://hdl.handle.net/20.500.12328/3819
https://dx.doi.org/10.3389/fendo.2023.1074757
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Endocrinology
14
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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