Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons

Hippocampal inhibitory neurons (INs) contact local targets and project to different brain areas to form synapses on distal neurons. Despite the importance of INs for hippocampal function and interregional brain communication, the impact of activity-dependent plasticity mechanisms on local and long-r...

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Autores: Hernández-Vivanco, Alicia, Jiménez-Redondo, Miguel, Cano-Adamuz, Nuria, Méndez, Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/347915
Acceso en línea:http://hdl.handle.net/10261/347915
Access Level:acceso abierto
Palabra clave:hippocampus
inhibitory neuron
parvalbumin
somatostatin
synaptic inhibition
synaptic plasticity.
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spelling Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing NeuronsHernández-Vivanco, AliciaJiménez-Redondo, MiguelCano-Adamuz, NuriaMéndez, Pablohippocampusinhibitory neuronparvalbuminsomatostatinsynaptic inhibitionsynaptic plasticity.Hippocampal inhibitory neurons (INs) contact local targets and project to different brain areas to form synapses on distal neurons. Despite the importance of INs for hippocampal function and interregional brain communication, the impact of activity-dependent plasticity mechanisms on local and long-range GABAergic synapses formed by hippocampal INs remains to be fully elucidated. Here, we use optogenetic-coupled electrophysiology in mice to show that protein kinase A (PKA), a master regulator of GABAergic synapse plasticity, causes a form of long-term potentiation of inhibitory synapses (iLTP) in hippocampal granule cells (GCs). This form of iLTP is observed in GCs synapses originated in local INs expressing the marker somatostatin (SST), but not in those expressing parvalbumin. Long-range synapses formed by SST INs onto medial septum neurons are unaffected by PKA activation. iLTP of local SST synapses on GCs is accompanied by changes in presynaptic probability of release and is occluded by pharmacological increase of synaptic activity in vivo Our results suggest that PKA-dependent inhibitory synapse plasticity is expressed in local, but not long-range, targets of SST INs and selectively modifies inhibitory microcircuits essential for hippocampal function.This work was supported by Grant RYC-2015-18545, funded by the Ministry of Science and Innovation (MCIN)/Agencia Estatal de Investigación (AEI) Grant 10.13039/501100011033 by “European Social Fund (ESF): Investing in Your Future”; and Grant BFU2017-84490-P funded by MCIN/AEI Grant 10.13039/501100011033 by the “European Regional Development Fund: A Way of Making Europe” to P.M. N.C.-A. is supported by PhD Fellowship PRE2018-084857 funded by MCIN/AEI Grant 10.13039/501100011033 by “ESF Investing in your future.”Society for NeuroscienceMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420232024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/347915reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//RYC-2015-18545info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-84490-Phttp://dx.doi.org/10.1523/ENEURO.0089-23.2023Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3479152026-05-22T06:33:51Z
dc.title.none.fl_str_mv Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
title Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
spellingShingle Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
Hernández-Vivanco, Alicia
hippocampus
inhibitory neuron
parvalbumin
somatostatin
synaptic inhibition
synaptic plasticity.
title_short Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
title_full Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
title_fullStr Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
title_full_unstemmed Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
title_sort Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons
dc.creator.none.fl_str_mv Hernández-Vivanco, Alicia
Jiménez-Redondo, Miguel
Cano-Adamuz, Nuria
Méndez, Pablo
author Hernández-Vivanco, Alicia
author_facet Hernández-Vivanco, Alicia
Jiménez-Redondo, Miguel
Cano-Adamuz, Nuria
Méndez, Pablo
author_role author
author2 Jiménez-Redondo, Miguel
Cano-Adamuz, Nuria
Méndez, Pablo
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv hippocampus
inhibitory neuron
parvalbumin
somatostatin
synaptic inhibition
synaptic plasticity.
topic hippocampus
inhibitory neuron
parvalbumin
somatostatin
synaptic inhibition
synaptic plasticity.
description Hippocampal inhibitory neurons (INs) contact local targets and project to different brain areas to form synapses on distal neurons. Despite the importance of INs for hippocampal function and interregional brain communication, the impact of activity-dependent plasticity mechanisms on local and long-range GABAergic synapses formed by hippocampal INs remains to be fully elucidated. Here, we use optogenetic-coupled electrophysiology in mice to show that protein kinase A (PKA), a master regulator of GABAergic synapse plasticity, causes a form of long-term potentiation of inhibitory synapses (iLTP) in hippocampal granule cells (GCs). This form of iLTP is observed in GCs synapses originated in local INs expressing the marker somatostatin (SST), but not in those expressing parvalbumin. Long-range synapses formed by SST INs onto medial septum neurons are unaffected by PKA activation. iLTP of local SST synapses on GCs is accompanied by changes in presynaptic probability of release and is occluded by pharmacological increase of synaptic activity in vivo Our results suggest that PKA-dependent inhibitory synapse plasticity is expressed in local, but not long-range, targets of SST INs and selectively modifies inhibitory microcircuits essential for hippocampal function.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/347915
url http://hdl.handle.net/10261/347915
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//RYC-2015-18545
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-84490-P
http://dx.doi.org/10.1523/ENEURO.0089-23.2023
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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