Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms

Fütterer, A. (Agnes)|||/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3; Campanero, M.R. (Miguel R.)|||/items/80f71834-044b-43ae-9f7f-cb23edb2b5a1; Leonardo, E. (Esther)|||/items/d11f83ac-6b6d-4d2c-a4f0-c57005b153e9; Criado, L.M. (Luis M.)|||/items/7384a142-d943-490d-a1b4-07802bac7a37; Flores, J.M. (Juana M.)|||/items/eb40ca4a-bd14-43f4-8985-18a687e0ffd4; Hernandez, J.M. (J. M.)|||/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31; San-Miguel, J.F. (Jesús F.)|||/items/114f598d-f226-4fa6-aa75-909241328543; Martínez, C. (Carlos)|||/items/ea48dee3-40ec-49f2-addc-150bfe182dad

Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms

The myelodysplastic/myeloproliferative diseases (MDS/MPDs) are a heterogeneous group of myeloid neoplasms that share characteristics with chronic myeloproliferative diseases and myelodysplastic syndromes. The broad spectrum of clinical manifestations makes MDS/MPDs extremely difficult to diagnose an...

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Autores:	Fütterer, A. (Agnes)\|\|\|/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3, Campanero, M.R. (Miguel R.)\|\|\|/items/80f71834-044b-43ae-9f7f-cb23edb2b5a1, Leonardo, E. (Esther)\|\|\|/items/d11f83ac-6b6d-4d2c-a4f0-c57005b153e9, Criado, L.M. (Luis M.)\|\|\|/items/7384a142-d943-490d-a1b4-07802bac7a37, Flores, J.M. (Juana M.)\|\|\|/items/eb40ca4a-bd14-43f4-8985-18a687e0ffd4, Hernandez, J.M. (J. M.)\|\|\|/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31, San-Miguel, J.F. (Jesús F.)\|\|\|/items/114f598d-f226-4fa6-aa75-909241328543, Martínez, C. (Carlos)\|\|\|/items/ea48dee3-40ec-49f2-addc-150bfe182dad
Tipo de recurso:	artículo
Fecha de publicación:	2005
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/66279
Acceso en línea:	https://hdl.handle.net/10171/66279
Access Level:	acceso abierto
Palabra clave:	Myelodysplastic Neoplasm Syndromes Myeloproliferative

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spelling	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasmsFütterer, A. (Agnes)\|\|\|/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3Campanero, M.R. (Miguel R.)\|\|\|/items/80f71834-044b-43ae-9f7f-cb23edb2b5a1Leonardo, E. (Esther)\|\|\|/items/d11f83ac-6b6d-4d2c-a4f0-c57005b153e9Criado, L.M. (Luis M.)\|\|\|/items/7384a142-d943-490d-a1b4-07802bac7a37Flores, J.M. (Juana M.)\|\|\|/items/eb40ca4a-bd14-43f4-8985-18a687e0ffd4Hernandez, J.M. (J. M.)\|\|\|/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31San-Miguel, J.F. (Jesús F.)\|\|\|/items/114f598d-f226-4fa6-aa75-909241328543Martínez, C. (Carlos)\|\|\|/items/ea48dee3-40ec-49f2-addc-150bfe182dadMyelodysplasticNeoplasmSyndromesMyeloproliferativeThe myelodysplastic/myeloproliferative diseases (MDS/MPDs) are a heterogeneous group of myeloid neoplasms that share characteristics with chronic myeloproliferative diseases and myelodysplastic syndromes. The broad spectrum of clinical manifestations makes MDS/MPDs extremely difficult to diagnose and treat, with a median survival time of 1-5 years. No single gene defect has been firmly associated with MDS/MPDs, and no animal models have been developed for these diseases. The association of deletions on chromosome 20q with myeloid malignancies suggests the presence of unidentified tumor suppressor genes in this region. Here we show that the recently identified death inducer-obliterator (Dido) gene gives rise to at least 3 polypeptides (Dido1, Dido2, and Dido3) through alternative splicing, and we map the human gene to the long arm of chromosome 20. We found that targeting of murine Dido caused a transplantable disease whose symptoms and signs suggested MDS/MPDs. Furthermore, 100% of human MDS/MPD patients analyzed showed Dido expression abnormalities, which we also found in other myeloid but not lymphoid neoplasms or in healthy donors. Our findings suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying MDS/MPD diseases and testing new approaches to their diagnosis and treatment.Dadun. Depósito Académico Digital Universidad de Navarra20232023-05-1720052005-01-0120052005-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/66279reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/662792026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
title	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
spellingShingle	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms Fütterer, A. (Agnes)\|\|\|/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3 Myelodysplastic Neoplasm Syndromes Myeloproliferative
title_short	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
title_full	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
title_fullStr	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
title_full_unstemmed	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
title_sort	Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
dc.creator.none.fl_str_mv	Fütterer, A. (Agnes)\|\|\|/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3 Campanero, M.R. (Miguel R.)\|\|\|/items/80f71834-044b-43ae-9f7f-cb23edb2b5a1 Leonardo, E. (Esther)\|\|\|/items/d11f83ac-6b6d-4d2c-a4f0-c57005b153e9 Criado, L.M. (Luis M.)\|\|\|/items/7384a142-d943-490d-a1b4-07802bac7a37 Flores, J.M. (Juana M.)\|\|\|/items/eb40ca4a-bd14-43f4-8985-18a687e0ffd4 Hernandez, J.M. (J. M.)\|\|\|/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31 San-Miguel, J.F. (Jesús F.)\|\|\|/items/114f598d-f226-4fa6-aa75-909241328543 Martínez, C. (Carlos)\|\|\|/items/ea48dee3-40ec-49f2-addc-150bfe182dad
author	Fütterer, A. (Agnes)\|\|\|/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3
author_facet	Fütterer, A. (Agnes)\|\|\|/items/5604e5bd-58eb-4c7f-a9f1-6530bcde94b3 Campanero, M.R. (Miguel R.)\|\|\|/items/80f71834-044b-43ae-9f7f-cb23edb2b5a1 Leonardo, E. (Esther)\|\|\|/items/d11f83ac-6b6d-4d2c-a4f0-c57005b153e9 Criado, L.M. (Luis M.)\|\|\|/items/7384a142-d943-490d-a1b4-07802bac7a37 Flores, J.M. (Juana M.)\|\|\|/items/eb40ca4a-bd14-43f4-8985-18a687e0ffd4 Hernandez, J.M. (J. M.)\|\|\|/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31 San-Miguel, J.F. (Jesús F.)\|\|\|/items/114f598d-f226-4fa6-aa75-909241328543 Martínez, C. (Carlos)\|\|\|/items/ea48dee3-40ec-49f2-addc-150bfe182dad
author_role	author
author2	Campanero, M.R. (Miguel R.)\|\|\|/items/80f71834-044b-43ae-9f7f-cb23edb2b5a1 Leonardo, E. (Esther)\|\|\|/items/d11f83ac-6b6d-4d2c-a4f0-c57005b153e9 Criado, L.M. (Luis M.)\|\|\|/items/7384a142-d943-490d-a1b4-07802bac7a37 Flores, J.M. (Juana M.)\|\|\|/items/eb40ca4a-bd14-43f4-8985-18a687e0ffd4 Hernandez, J.M. (J. M.)\|\|\|/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31 San-Miguel, J.F. (Jesús F.)\|\|\|/items/114f598d-f226-4fa6-aa75-909241328543 Martínez, C. (Carlos)\|\|\|/items/ea48dee3-40ec-49f2-addc-150bfe182dad
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Myelodysplastic Neoplasm Syndromes Myeloproliferative
topic	Myelodysplastic Neoplasm Syndromes Myeloproliferative
description	The myelodysplastic/myeloproliferative diseases (MDS/MPDs) are a heterogeneous group of myeloid neoplasms that share characteristics with chronic myeloproliferative diseases and myelodysplastic syndromes. The broad spectrum of clinical manifestations makes MDS/MPDs extremely difficult to diagnose and treat, with a median survival time of 1-5 years. No single gene defect has been firmly associated with MDS/MPDs, and no animal models have been developed for these diseases. The association of deletions on chromosome 20q with myeloid malignancies suggests the presence of unidentified tumor suppressor genes in this region. Here we show that the recently identified death inducer-obliterator (Dido) gene gives rise to at least 3 polypeptides (Dido1, Dido2, and Dido3) through alternative splicing, and we map the human gene to the long arm of chromosome 20. We found that targeting of murine Dido caused a transplantable disease whose symptoms and signs suggested MDS/MPDs. Furthermore, 100% of human MDS/MPD patients analyzed showed Dido expression abnormalities, which we also found in other myeloid but not lymphoid neoplasms or in healthy donors. Our findings suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying MDS/MPD diseases and testing new approaches to their diagnosis and treatment.
publishDate	2005
dc.date.none.fl_str_mv	2005 2005-01-01 2005 2005-01-01 2023 2023-05-17
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/66279
url	https://hdl.handle.net/10171/66279
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
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Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms

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