Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial

BackgroundGiven the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of...

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Autores: Vicent-Gil, M, Raventos, B, Marin-Martinez, ED, Gonzalez-Simarro, S, Martinez-Aran, A, Bonnin, CD, Trujols, J, Perez-Blanco, J, de Diego-Adelino, J, Puigdemont, D, Serra-Blasco, M, Cardoner, N, Portella, MJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p3004
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/3004
Access Level:acceso abierto
Palabra clave:Cognitive remediation
Depression
Functional remediation
Computerized cognitive training
Clinical trial
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spelling Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trialVicent-Gil, MRaventos, BMarin-Martinez, EDGonzalez-Simarro, SMartinez-Aran, ABonnin, CDTrujols, JPerez-Blanco, Jde Diego-Adelino, JPuigdemont, DSerra-Blasco, MCardoner, NPortella, MJCognitive remediationDepressionFunctional remediationComputerized cognitive trainingClinical trialBackgroundGiven the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life.MethodsA single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR+CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes.DiscussionTo our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR+CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning.Trial registrationClinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018.BMC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/3004BMC PsychiatryISSN: 1471244Xreponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p30042026-06-21T15:30:37Z
dc.title.none.fl_str_mv Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
title Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
spellingShingle Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
Vicent-Gil, M
Cognitive remediation
Depression
Functional remediation
Computerized cognitive training
Clinical trial
title_short Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
title_full Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
title_fullStr Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
title_full_unstemmed Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
title_sort Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
dc.creator.none.fl_str_mv Vicent-Gil, M
Raventos, B
Marin-Martinez, ED
Gonzalez-Simarro, S
Martinez-Aran, A
Bonnin, CD
Trujols, J
Perez-Blanco, J
de Diego-Adelino, J
Puigdemont, D
Serra-Blasco, M
Cardoner, N
Portella, MJ
author Vicent-Gil, M
author_facet Vicent-Gil, M
Raventos, B
Marin-Martinez, ED
Gonzalez-Simarro, S
Martinez-Aran, A
Bonnin, CD
Trujols, J
Perez-Blanco, J
de Diego-Adelino, J
Puigdemont, D
Serra-Blasco, M
Cardoner, N
Portella, MJ
author_role author
author2 Raventos, B
Marin-Martinez, ED
Gonzalez-Simarro, S
Martinez-Aran, A
Bonnin, CD
Trujols, J
Perez-Blanco, J
de Diego-Adelino, J
Puigdemont, D
Serra-Blasco, M
Cardoner, N
Portella, MJ
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cognitive remediation
Depression
Functional remediation
Computerized cognitive training
Clinical trial
topic Cognitive remediation
Depression
Functional remediation
Computerized cognitive training
Clinical trial
description BackgroundGiven the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life.MethodsA single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR+CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes.DiscussionTo our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR+CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning.Trial registrationClinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/3004
url https://i3pt.portalinvestigacion.com/publicaciones/3004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv BMC Psychiatry
ISSN: 1471244X
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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