Growth factor loaded-microparticles as a tool for cardiac repair

The clinical trials performed in patients with myocardial infarction and based on the intravascular injection of growth factors have failed, owing, among other reasons, to protein instability after injection. The hypothesis of this research is that a local controlled release of the growth factors by...

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Detalles Bibliográficos
Autor: Rocha, F. (Fabio)|||/items/6484a44a-2639-4dee-b5af-621db1fab03e
Tipo de recurso: tesis doctoral
Fecha de publicación:2011
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/34921
Acceso en línea:https://hdl.handle.net/10171/34921
Access Level:acceso abierto
Palabra clave:Materias Investigacion::Farmacia
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spelling Growth factor loaded-microparticles as a tool for cardiac repairRocha, F. (Fabio)|||/items/6484a44a-2639-4dee-b5af-621db1fab03eMaterias Investigacion::FarmaciaThe clinical trials performed in patients with myocardial infarction and based on the intravascular injection of growth factors have failed, owing, among other reasons, to protein instability after injection. The hypothesis of this research is that a local controlled release of the growth factors by using a polymeric delivery system could protect the growth factors from degradation and stimulate cardiac repair. To test this, the following specific objectives were proposed: 1. Design, development and physico-chemical characterization of PLGA microparticles intended for intramyocardial administration. In vivo compatibility assessment of the developed microparticles with the cardiac tissue. 2. Development of VEGF165 loaded PLGA microparticles, in vitro characterization and assessment of the potential benefit of the VEGF165-microparticles in an acute rat myocardial ischemia– reperfusion model. 3. Development of FGF-1 and NRG-1 into PLGA microparticles, in vitro characterization and evaluation of the therapeutic potential of FGF-1 and/or NRG-1 cytokines delivered from PLGA microparticles in a rat myocardial infarction model.Servicio de Publicaciones Universidad de NavarraBlanco-Prieto, M.J. (María José)Pelacho-Samper, B. (Beatriz)Dadun. Depósito Académico Digital Universidad de Navarra20142014-01-2220142014-01-0120142014-01-0120112011-12-15doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10171/34921reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/349212026-06-21T12:47:57Z
dc.title.none.fl_str_mv Growth factor loaded-microparticles as a tool for cardiac repair
title Growth factor loaded-microparticles as a tool for cardiac repair
spellingShingle Growth factor loaded-microparticles as a tool for cardiac repair
Rocha, F. (Fabio)|||/items/6484a44a-2639-4dee-b5af-621db1fab03e
Materias Investigacion::Farmacia
title_short Growth factor loaded-microparticles as a tool for cardiac repair
title_full Growth factor loaded-microparticles as a tool for cardiac repair
title_fullStr Growth factor loaded-microparticles as a tool for cardiac repair
title_full_unstemmed Growth factor loaded-microparticles as a tool for cardiac repair
title_sort Growth factor loaded-microparticles as a tool for cardiac repair
dc.creator.none.fl_str_mv Rocha, F. (Fabio)|||/items/6484a44a-2639-4dee-b5af-621db1fab03e
author Rocha, F. (Fabio)|||/items/6484a44a-2639-4dee-b5af-621db1fab03e
author_facet Rocha, F. (Fabio)|||/items/6484a44a-2639-4dee-b5af-621db1fab03e
author_role author
dc.contributor.none.fl_str_mv Blanco-Prieto, M.J. (María José)
Pelacho-Samper, B. (Beatriz)
Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Materias Investigacion::Farmacia
topic Materias Investigacion::Farmacia
description The clinical trials performed in patients with myocardial infarction and based on the intravascular injection of growth factors have failed, owing, among other reasons, to protein instability after injection. The hypothesis of this research is that a local controlled release of the growth factors by using a polymeric delivery system could protect the growth factors from degradation and stimulate cardiac repair. To test this, the following specific objectives were proposed: 1. Design, development and physico-chemical characterization of PLGA microparticles intended for intramyocardial administration. In vivo compatibility assessment of the developed microparticles with the cardiac tissue. 2. Development of VEGF165 loaded PLGA microparticles, in vitro characterization and assessment of the potential benefit of the VEGF165-microparticles in an acute rat myocardial ischemia– reperfusion model. 3. Development of FGF-1 and NRG-1 into PLGA microparticles, in vitro characterization and evaluation of the therapeutic potential of FGF-1 and/or NRG-1 cytokines delivered from PLGA microparticles in a rat myocardial infarction model.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-12-15
2014
2014-01-22
2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/34921
url https://hdl.handle.net/10171/34921
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Servicio de Publicaciones Universidad de Navarra
publisher.none.fl_str_mv Servicio de Publicaciones Universidad de Navarra
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
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