PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans

Apoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in...

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Autores: Cabello, J., Sämann, J., Gómez Orte, E., Erazo, T., Coppa, Andrea, Pujol Onofre, Aurora, Büssing, I., Schulze, B., Lizcano, José Miguel, Baumeister, R., Ferrer, Isidro (Ferrer Abizanda), Dalfó Capella, Esther
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125929
Acceso en línea:https://hdl.handle.net/2445/125929
Access Level:acceso abierto
Palabra clave:Mort cel·lular
Homeòstasi
Cell death
Homeostasis
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spelling PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegansCabello, J.Sämann, J.Gómez Orte, E.Erazo, T.Coppa, AndreaPujol Onofre, AuroraBüssing, I.Schulze, B.Lizcano, José MiguelBaumeister, R.Ferrer, Isidro (Ferrer Abizanda)Dalfó Capella, EstherMort cel·lularHomeòstasiCell deathHomeostasisApoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. In Caenorhabditis elegans, two parallel and partly redundant conserved pathways act in cell corpse engulfment. The pathway for cytoskeletal rearrangement requires the small GTPase CED-10 Rac1 acting for an efficient surround of the dead cell. The CED-10 Rac pathway is also required for the proper migration of the distal tip cells (DTCs) during the development of the C. elegans gonad. Parkin, the mammalian homolog of the C. elegans PDR-1, interacts with Rac1 in aged human brain and it is also implicated with actin dynamics and cytoskeletal rearrangements in Parkinsons's disease, suggesting that it might act on engulfment. Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation.Nature Publishing Group2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/125929Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/cddis.2014.57Cell Death and Disease, 2014, num. 5, p. e1120https://doi.org/10.1038/cddis.2014.57cc-by-nc-sa (c) Cabello, J. et al., 2014http://creativecommons.org/licenses/by-nc-sa/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1259292026-05-27T06:46:51Z
dc.title.none.fl_str_mv PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
title PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
spellingShingle PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
Cabello, J.
Mort cel·lular
Homeòstasi
Cell death
Homeostasis
title_short PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
title_full PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
title_fullStr PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
title_full_unstemmed PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
title_sort PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
dc.creator.none.fl_str_mv Cabello, J.
Sämann, J.
Gómez Orte, E.
Erazo, T.
Coppa, Andrea
Pujol Onofre, Aurora
Büssing, I.
Schulze, B.
Lizcano, José Miguel
Baumeister, R.
Ferrer, Isidro (Ferrer Abizanda)
Dalfó Capella, Esther
author Cabello, J.
author_facet Cabello, J.
Sämann, J.
Gómez Orte, E.
Erazo, T.
Coppa, Andrea
Pujol Onofre, Aurora
Büssing, I.
Schulze, B.
Lizcano, José Miguel
Baumeister, R.
Ferrer, Isidro (Ferrer Abizanda)
Dalfó Capella, Esther
author_role author
author2 Sämann, J.
Gómez Orte, E.
Erazo, T.
Coppa, Andrea
Pujol Onofre, Aurora
Büssing, I.
Schulze, B.
Lizcano, José Miguel
Baumeister, R.
Ferrer, Isidro (Ferrer Abizanda)
Dalfó Capella, Esther
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mort cel·lular
Homeòstasi
Cell death
Homeostasis
topic Mort cel·lular
Homeòstasi
Cell death
Homeostasis
description Apoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. In Caenorhabditis elegans, two parallel and partly redundant conserved pathways act in cell corpse engulfment. The pathway for cytoskeletal rearrangement requires the small GTPase CED-10 Rac1 acting for an efficient surround of the dead cell. The CED-10 Rac pathway is also required for the proper migration of the distal tip cells (DTCs) during the development of the C. elegans gonad. Parkin, the mammalian homolog of the C. elegans PDR-1, interacts with Rac1 in aged human brain and it is also implicated with actin dynamics and cytoskeletal rearrangements in Parkinsons's disease, suggesting that it might act on engulfment. Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125929
url https://hdl.handle.net/2445/125929
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/cddis.2014.57
Cell Death and Disease, 2014, num. 5, p. e1120
https://doi.org/10.1038/cddis.2014.57
dc.rights.none.fl_str_mv cc-by-nc-sa (c) Cabello, J. et al., 2014
http://creativecommons.org/licenses/by-nc-sa/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-sa (c) Cabello, J. et al., 2014
http://creativecommons.org/licenses/by-nc-sa/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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