From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model

Background: The clinical utility of skin allografts (SA) is well established. However, the donation and procurement of cadaveric skin-historically the primary source of SA-remain limited in many countries. A skin donation model based on the use of excess surgical tissue from body contouring procedur...

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Autores: Fonseca, M, Cañete, A, Mandriaza, L, Gómez, J, Masiá, J, Marcelain, K, Ibaceta, D, Erazo, C, Gamez, B, Soto, C, Valdés, C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19835
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19835
Access Level:acceso abierto
Palabra clave:Allografts
Skin
Skin transplantation
Skin banks
Tissue donors
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spelling From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation modelFonseca, MCañete, AMandriaza, LGómez, JMasiá, JMarcelain, KIbaceta, DErazo, CGamez, BSoto, CValdés, CAllograftsSkinSkin transplantationSkin banksTissue donorsBackground: The clinical utility of skin allografts (SA) is well established. However, the donation and procurement of cadaveric skin-historically the primary source of SA-remain limited in many countries. A skin donation model based on the use of excess surgical tissue from body contouring procedures was introduced and compared with the traditional cadaveric donation model. Methods: A retrospective review of skin donations in Chile was conducted over two periods (2017-2019 and 2022-2024), analyzing the performance and characteristics of two donation pathways: cadaveric and living donors. Results: During the first period (2017-2019), four cadaveric donors provided a total of 10,959 cm2 of skin. In the second period (2022-2024), 353 donors contributed 153,585 cm2 of skin, of which 348 were living donors (131,997 cm2) and five were cadaveric (21,588 cm2). Conclusions: Initially conceived as a complementary strategy, the living donor model has evolved to become the primary source of skin allografts in Chile. This approach significantly increases the availability of SA, broadens therapeutic indications, and promotes the concept of transforming excess surgical tissue into valuable therapeutic resources. Moreover, it enables the production of cryopreserved full-thickness skin allografts (CTSA), which serve not only as temporary wound coverage but also as dermal regenerative scaffolds, particularly beneficial in the treatment of burns affecting functionally and aesthetically critical areas. This new paradigm supports a more accessible and sustainable culture of skin donation while offering promising benefits for regenerative burn care.ELSEVIER SCI LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19835BURNSISSN: 03054179ISSNe: 18791409reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p198352026-06-14T12:41:47Z
dc.title.none.fl_str_mv From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
title From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
spellingShingle From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
Fonseca, M
Allografts
Skin
Skin transplantation
Skin banks
Tissue donors
title_short From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
title_full From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
title_fullStr From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
title_full_unstemmed From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
title_sort From cadaveric donation to cryopreserved total skin allografts: Transforming the Chilean skin donation model
dc.creator.none.fl_str_mv Fonseca, M
Cañete, A
Mandriaza, L
Gómez, J
Masiá, J
Marcelain, K
Ibaceta, D
Erazo, C
Gamez, B
Soto, C
Valdés, C
author Fonseca, M
author_facet Fonseca, M
Cañete, A
Mandriaza, L
Gómez, J
Masiá, J
Marcelain, K
Ibaceta, D
Erazo, C
Gamez, B
Soto, C
Valdés, C
author_role author
author2 Cañete, A
Mandriaza, L
Gómez, J
Masiá, J
Marcelain, K
Ibaceta, D
Erazo, C
Gamez, B
Soto, C
Valdés, C
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Allografts
Skin
Skin transplantation
Skin banks
Tissue donors
topic Allografts
Skin
Skin transplantation
Skin banks
Tissue donors
description Background: The clinical utility of skin allografts (SA) is well established. However, the donation and procurement of cadaveric skin-historically the primary source of SA-remain limited in many countries. A skin donation model based on the use of excess surgical tissue from body contouring procedures was introduced and compared with the traditional cadaveric donation model. Methods: A retrospective review of skin donations in Chile was conducted over two periods (2017-2019 and 2022-2024), analyzing the performance and characteristics of two donation pathways: cadaveric and living donors. Results: During the first period (2017-2019), four cadaveric donors provided a total of 10,959 cm2 of skin. In the second period (2022-2024), 353 donors contributed 153,585 cm2 of skin, of which 348 were living donors (131,997 cm2) and five were cadaveric (21,588 cm2). Conclusions: Initially conceived as a complementary strategy, the living donor model has evolved to become the primary source of skin allografts in Chile. This approach significantly increases the availability of SA, broadens therapeutic indications, and promotes the concept of transforming excess surgical tissue into valuable therapeutic resources. Moreover, it enables the production of cryopreserved full-thickness skin allografts (CTSA), which serve not only as temporary wound coverage but also as dermal regenerative scaffolds, particularly beneficial in the treatment of burns affecting functionally and aesthetically critical areas. This new paradigm supports a more accessible and sustainable culture of skin donation while offering promising benefits for regenerative burn care.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19835
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19835
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv BURNS
ISSN: 03054179
ISSNe: 18791409
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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