Chitin Synthesis in Yeast: A Matter of Trafficking

Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin sy...

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Authors: Sánchez Núñez, Noelia, Roncero, Cesar
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/288332
Online Access:http://hdl.handle.net/10261/288332
Access Level:Open access
Keyword:Yeasts
Chitin synthase
Intracellular traffic
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spelling Chitin Synthesis in Yeast: A Matter of TraffickingSánchez Núñez, NoeliaRoncero, CesarYeastsChitin synthaseIntracellular trafficChitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin synthase in yeast, Chs3, as an authentic paradigm in the field of the intracellular trafficking of integral membrane proteins. Over the years, researchers have shown how the intracellular trafficking of Chs3 recapitulates all the steps in the intracellular trafficking of integral membrane proteins, from their synthesis in the endoplasmic reticulum to their degradation in the vacuole. This trafficking includes specific mechanisms for sorting in the trans-Golgi network, regulated endocytosis, and endosomal recycling at different levels. This review summarizes the work carried out on chitin synthesis regulation, mostly focusing on Chs3 as a molecular model to study the mechanisms involved in the control of the intracellular trafficking of proteins.The funding for this research was provided by the Ministerio de Ciencia e Innovacion of Spain (Grant PID2020-115111GB-I00) and an institutional grant to the IBFG (CLU-2017-03) provided by the Junta the Castilla y León through the program “Escalera de Excelencia,” co-financed by the PO FEDER of Castilla y León 14-20. N.S. was supported by an FPU fellowship from the Spanish Ministry of Education.Multidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)Junta de Castilla y LeónEuropean CommissionMinisterio de Educación (España)Roncero, Cesar [0000-0001-5964-3252]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/288332reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115111GB-I00http://dx.doi.org/10.3390/ijms232012251Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2883322026-05-22T06:33:51Z
dc.title.none.fl_str_mv Chitin Synthesis in Yeast: A Matter of Trafficking
title Chitin Synthesis in Yeast: A Matter of Trafficking
spellingShingle Chitin Synthesis in Yeast: A Matter of Trafficking
Sánchez Núñez, Noelia
Yeasts
Chitin synthase
Intracellular traffic
title_short Chitin Synthesis in Yeast: A Matter of Trafficking
title_full Chitin Synthesis in Yeast: A Matter of Trafficking
title_fullStr Chitin Synthesis in Yeast: A Matter of Trafficking
title_full_unstemmed Chitin Synthesis in Yeast: A Matter of Trafficking
title_sort Chitin Synthesis in Yeast: A Matter of Trafficking
dc.creator.none.fl_str_mv Sánchez Núñez, Noelia
Roncero, Cesar
author Sánchez Núñez, Noelia
author_facet Sánchez Núñez, Noelia
Roncero, Cesar
author_role author
author2 Roncero, Cesar
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Junta de Castilla y León
European Commission
Ministerio de Educación (España)
Roncero, Cesar [0000-0001-5964-3252]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Yeasts
Chitin synthase
Intracellular traffic
topic Yeasts
Chitin synthase
Intracellular traffic
description Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin synthase in yeast, Chs3, as an authentic paradigm in the field of the intracellular trafficking of integral membrane proteins. Over the years, researchers have shown how the intracellular trafficking of Chs3 recapitulates all the steps in the intracellular trafficking of integral membrane proteins, from their synthesis in the endoplasmic reticulum to their degradation in the vacuole. This trafficking includes specific mechanisms for sorting in the trans-Golgi network, regulated endocytosis, and endosomal recycling at different levels. This review summarizes the work carried out on chitin synthesis regulation, mostly focusing on Chs3 as a molecular model to study the mechanisms involved in the control of the intracellular trafficking of proteins.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/288332
url http://hdl.handle.net/10261/288332
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115111GB-I00
http://dx.doi.org/10.3390/ijms232012251
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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