Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis
Background: Cognitive profiles of BD patients show a demonstrated heterogeneity among young and middle-aged patients, but this issue has not yet deeply explored in Older Adults with bipolar disorder (OABD). The aim of the present study was to analyze cognitive variability in a sample of OABD. Method...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/225523 |
| Acceso en línea: | https://hdl.handle.net/2445/225523 |
| Access Level: | acceso abierto |
| Palabra clave: | Cognició Trastorn bipolar Neuropsicologia Anàlisi de conglomerats Cognition Manic-depressive illness Neuropsychology Cluster analysis |
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Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysisMontejo Egido, LauraJiménez Martínez, EsterSolé Cabezuelo, BrisaMurru, AndreaArbelo, NéstorBenabarre, AntonioValentí Ribas, MarcClougher, DerekRodríguez, M.A.Borràs, RogerMartínez-Arán, Anabel, 1971-Vieta i Pascual, Eduard, 1963-Bonnín Roig, Caterina del MarTorrent Font, CarlaCognicióTrastorn bipolarNeuropsicologiaAnàlisi de conglomeratsCognitionManic-depressive illnessNeuropsychologyCluster analysisBackground: Cognitive profiles of BD patients show a demonstrated heterogeneity among young and middle-aged patients, but this issue has not yet deeply explored in Older Adults with bipolar disorder (OABD). The aim of the present study was to analyze cognitive variability in a sample of OABD. Methods: A total of 138 OABD patients and 73 healthy controls were included in this study. A comprehensive neuropsychological assessment was administered. We performed a k-means cluster analysis method based on the neurocognitive performance to detect heterogeneous subgroups. Demographic, clinical, cognitive and functional variables were compared. Finally, univariate logistic regressions were conducted to detect variables associated with the severity of the cognitive impairment. Results: We identified three distinct clusters based on the severity of cognitive impairment: (1) a preserved group (n = 58; 42%) with similar cognitive performance to HC, (2) a group showing mild cognitive deficits in all cognitive domains (n = 64; 46%) and, finally, (3) a group exhibiting severe cognitive impairment (n = 16; 12%). Older age, late onset, higher number of psychiatric admissions and lower psychosocial functioning were associated with the greatest cognitive impairment. Lower age, more years of education and higher estimated IQ were associated with a preserve cognitive functioning. Limitations: The small sample size of the severely impaired group. Conclusions: Cognitive heterogeneity remains at late-life bipolar disorder. Demographic and specific illness factors are related to cognitive dysfunction. Detecting distinct cognitive subgroups may have significant clinical implications for tailoring specific intervention strategies adapted to the level of the impairment and also to prevent cognitive decline.Elsevier B.V.2026202620222026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion71 p.application/pdfhttps://hdl.handle.net/2445/225523Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.jad.2021.11.028Journal of Affective Disorders, 2022, vol. 298, num.Part A, p. 522-531https://doi.org/10.1016/j.jad.2021.11.028cc-by-nc-nd (c) Elsevier B.V., 2022http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2255232026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| title |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| spellingShingle |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis Montejo Egido, Laura Cognició Trastorn bipolar Neuropsicologia Anàlisi de conglomerats Cognition Manic-depressive illness Neuropsychology Cluster analysis |
| title_short |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| title_full |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| title_fullStr |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| title_full_unstemmed |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| title_sort |
Identifying neurocognitive heterogeneity in Older Adults with Bipolar Disorder: a cluster analysis |
| dc.creator.none.fl_str_mv |
Montejo Egido, Laura Jiménez Martínez, Ester Solé Cabezuelo, Brisa Murru, Andrea Arbelo, Néstor Benabarre, Antonio Valentí Ribas, Marc Clougher, Derek Rodríguez, M.A. Borràs, Roger Martínez-Arán, Anabel, 1971- Vieta i Pascual, Eduard, 1963- Bonnín Roig, Caterina del Mar Torrent Font, Carla |
| author |
Montejo Egido, Laura |
| author_facet |
Montejo Egido, Laura Jiménez Martínez, Ester Solé Cabezuelo, Brisa Murru, Andrea Arbelo, Néstor Benabarre, Antonio Valentí Ribas, Marc Clougher, Derek Rodríguez, M.A. Borràs, Roger Martínez-Arán, Anabel, 1971- Vieta i Pascual, Eduard, 1963- Bonnín Roig, Caterina del Mar Torrent Font, Carla |
| author_role |
author |
| author2 |
Jiménez Martínez, Ester Solé Cabezuelo, Brisa Murru, Andrea Arbelo, Néstor Benabarre, Antonio Valentí Ribas, Marc Clougher, Derek Rodríguez, M.A. Borràs, Roger Martínez-Arán, Anabel, 1971- Vieta i Pascual, Eduard, 1963- Bonnín Roig, Caterina del Mar Torrent Font, Carla |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cognició Trastorn bipolar Neuropsicologia Anàlisi de conglomerats Cognition Manic-depressive illness Neuropsychology Cluster analysis |
| topic |
Cognició Trastorn bipolar Neuropsicologia Anàlisi de conglomerats Cognition Manic-depressive illness Neuropsychology Cluster analysis |
| description |
Background: Cognitive profiles of BD patients show a demonstrated heterogeneity among young and middle-aged patients, but this issue has not yet deeply explored in Older Adults with bipolar disorder (OABD). The aim of the present study was to analyze cognitive variability in a sample of OABD. Methods: A total of 138 OABD patients and 73 healthy controls were included in this study. A comprehensive neuropsychological assessment was administered. We performed a k-means cluster analysis method based on the neurocognitive performance to detect heterogeneous subgroups. Demographic, clinical, cognitive and functional variables were compared. Finally, univariate logistic regressions were conducted to detect variables associated with the severity of the cognitive impairment. Results: We identified three distinct clusters based on the severity of cognitive impairment: (1) a preserved group (n = 58; 42%) with similar cognitive performance to HC, (2) a group showing mild cognitive deficits in all cognitive domains (n = 64; 46%) and, finally, (3) a group exhibiting severe cognitive impairment (n = 16; 12%). Older age, late onset, higher number of psychiatric admissions and lower psychosocial functioning were associated with the greatest cognitive impairment. Lower age, more years of education and higher estimated IQ were associated with a preserve cognitive functioning. Limitations: The small sample size of the severely impaired group. Conclusions: Cognitive heterogeneity remains at late-life bipolar disorder. Demographic and specific illness factors are related to cognitive dysfunction. Detecting distinct cognitive subgroups may have significant clinical implications for tailoring specific intervention strategies adapted to the level of the impairment and also to prevent cognitive decline. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
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article |
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acceptedVersion |
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https://hdl.handle.net/2445/225523 |
| url |
https://hdl.handle.net/2445/225523 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1016/j.jad.2021.11.028 Journal of Affective Disorders, 2022, vol. 298, num.Part A, p. 522-531 https://doi.org/10.1016/j.jad.2021.11.028 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) Elsevier B.V., 2022 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc-nd (c) Elsevier B.V., 2022 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
71 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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Articles publicats en revistes (Psicologia Clínica i Psicobiologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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