Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Current knowledge of thalamocortical interaction comes mainly fro...

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Detalles Bibliográficos
Autores: Castejón, Carlos, Barros-Zulaica, Natali, Núñez Molina, Ángel
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/676659
Acceso en línea:http://hdl.handle.net/10486/676659
https://dx.doi.org/10.1371/journal.pone.0148169
Access Level:acceso abierto
Palabra clave:Brain function
Electrophysiology parameters
Primary somatosensory cortex
Somatosensory cortex
Medicina
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spelling Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical functionCastejón, CarlosBarros-Zulaica, NataliNúñez Molina, ÁngelBrain functionElectrophysiology parametersPrimary somatosensory cortexSomatosensory cortexMedicinaThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Current knowledge of thalamocortical interaction comes mainly from studying lemniscal thalamic systems. Less is known about paralemniscal thalamic nuclei function. In the vibrissae system, the posterior medial nucleus (POm) is the corresponding paralemniscal nucleus. POm neurons project to L1 and L5A of the primary somatosensory cortex (S1) in the rat brain. It is known that L1 modifies sensory-evoked responses through control of intracortical excitability suggesting that L1 exerts an influence on whisker responses. Therefore, thalamocortical pathways targeting L1 could modulate cortical firing. Here, using a combination of electrophysiology and pharmacology in vivo, we have sought to determine how POm influences cortical processing. In our experiments, single unit recordings performed in urethane- anesthetized rats showed that POm imposes precise control on the magnitude and duration of supra- and infragranular barrel cortex whisker responses. Our findings demonstrated that L1 inputs from POm imposed a time and intensity dependent regulation on cortical sensory processing. Moreover, we found that blocking L1 GABAergic inhibition or blocking P/Q-type Ca2+ channels in L1 prevents POm adjustment of whisker responses in the barrel cortex. Additionally, we found that POm was also controlling the sensory processing in S2 and this regulation was modulated by corticofugal activity from L5 in S1. Taken together, our data demonstrate the determinant role exerted by the POm in the adjustment of somatosensory cortical processing and in the regulation of cortical processing between S1 and S2. We propose that this adjustment could be a thalamocortical gain regulation mechanism also present in the processing of information between cortical areas.This work was supported by a grant from Ministerio de Economia y Competitividad (BFU2012- 36107)Public Library of ScienceDepartamento de Anatomía, Histología y NeurocienciaFacultad de Medicina20162016-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/676659https://dx.doi.org/10.1371/journal.pone.0148169reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6766592026-06-23T12:46:27Z
dc.title.none.fl_str_mv Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
title Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
spellingShingle Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
Castejón, Carlos
Brain function
Electrophysiology parameters
Primary somatosensory cortex
Somatosensory cortex
Medicina
title_short Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
title_full Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
title_fullStr Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
title_full_unstemmed Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
title_sort Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function
dc.creator.none.fl_str_mv Castejón, Carlos
Barros-Zulaica, Natali
Núñez Molina, Ángel
author Castejón, Carlos
author_facet Castejón, Carlos
Barros-Zulaica, Natali
Núñez Molina, Ángel
author_role author
author2 Barros-Zulaica, Natali
Núñez Molina, Ángel
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Anatomía, Histología y Neurociencia
Facultad de Medicina
dc.subject.none.fl_str_mv Brain function
Electrophysiology parameters
Primary somatosensory cortex
Somatosensory cortex
Medicina
topic Brain function
Electrophysiology parameters
Primary somatosensory cortex
Somatosensory cortex
Medicina
description This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Current knowledge of thalamocortical interaction comes mainly from studying lemniscal thalamic systems. Less is known about paralemniscal thalamic nuclei function. In the vibrissae system, the posterior medial nucleus (POm) is the corresponding paralemniscal nucleus. POm neurons project to L1 and L5A of the primary somatosensory cortex (S1) in the rat brain. It is known that L1 modifies sensory-evoked responses through control of intracortical excitability suggesting that L1 exerts an influence on whisker responses. Therefore, thalamocortical pathways targeting L1 could modulate cortical firing. Here, using a combination of electrophysiology and pharmacology in vivo, we have sought to determine how POm influences cortical processing. In our experiments, single unit recordings performed in urethane- anesthetized rats showed that POm imposes precise control on the magnitude and duration of supra- and infragranular barrel cortex whisker responses. Our findings demonstrated that L1 inputs from POm imposed a time and intensity dependent regulation on cortical sensory processing. Moreover, we found that blocking L1 GABAergic inhibition or blocking P/Q-type Ca2+ channels in L1 prevents POm adjustment of whisker responses in the barrel cortex. Additionally, we found that POm was also controlling the sensory processing in S2 and this regulation was modulated by corticofugal activity from L5 in S1. Taken together, our data demonstrate the determinant role exerted by the POm in the adjustment of somatosensory cortical processing and in the regulation of cortical processing between S1 and S2. We propose that this adjustment could be a thalamocortical gain regulation mechanism also present in the processing of information between cortical areas.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/676659
https://dx.doi.org/10.1371/journal.pone.0148169
url http://hdl.handle.net/10486/676659
https://dx.doi.org/10.1371/journal.pone.0148169
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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