Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials

Intrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in seve...

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Detalles Bibliográficos
Autores: Bettinardi, Ruggero G., Tort-Colet, Núria, Ruiz Mejias, Marcel, Sanchez-Vives, Maria V., Deco, Gustavo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26160
Acceso en línea:http://hdl.handle.net/10230/26160
http://dx.doi.org/10.1016/j.neuroimage.2015.03.037
Access Level:acceso abierto
Palabra clave:Brain states
Connectivity
Anesthesia levels
Default-mode network
Alpha rhythm
Gamma rhythm
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spelling Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentialsBettinardi, Ruggero G.Tort-Colet, NúriaRuiz Mejias, MarcelSanchez-Vives, Maria V.Deco, GustavoBrain statesConnectivityAnesthesia levelsDefault-mode networkAlpha rhythmGamma rhythmIntrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in several neurobiological disorders. In the present study, we induced a deep state of anesthesia in rats by means of a ketamine/medetomidine peritoneal injection, and analyzed the time course of the correlation between the brain activity in different areas while anesthesia spontaneously decreased over time. We compared results separately obtained from fMRI and local field potentials (LFPs) under the same anesthesia protocol, finding that while most profound phases of anesthesia can be described by overall sparse connectivity, stereotypical activity and poor functional integration, during lighter states different frequency-specific functional networks emerge, endowing the gradual restoration of structured large-scale activity seen during rest. Noteworthy, our in vivo results show that those areas belonging to the same functional network (the default-mode) exhibited sustained correlated oscillations around 10 Hz throughout the protocol, suggesting the presence of a specific functional backbone that is preserved even during deeper phases of anesthesia. Finally, the overall pattern of results obtained from both imaging and in vivo-recordings suggests that the progressive emergence from deep anesthesia is reflected by a corresponding gradual increase of organized correlated oscillations across the cortex.The research reported herein was supported by the ERC Advanced Grant DYSTRUCTURE (No. 295129), FET Flagship Human Brain Project, Brain Network Recovery Group through the James S. McDonnell Foundation (220020255), FP7-ICT BrainScales (No. 269921), CORONET (No. 269459), Ministerio de Economia y Competitividad (MINECO-PSI2013-42091-P), and Agència Gestió d'Ajuts Universitaris i de Recerca (2009SGR292) to G.D. M.V.S.V. was supported by the Ministerio de Economía y Competitividad (Spain)BFU2011-27094 and EU project CORTICONIC Contract number 600806.Elsevier201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26160http://dx.doi.org/10.1016/j.neuroimage.2015.03.037reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuroImage. 2015;114:185-198info:eu-repo/grantAgreement/EC/FP7/295129info:eu-repo/grantAgreement/EC/FP7/269921info:eu-repo/grantAgreement/EC/FP7/269459info:eu-repo/grantAgreement/EC/FP7/600806info:eu-repo/grantAgreement/EC/FP7/604102info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-Pinfo:eu-repo/grantAgreement/ES/3PN/BFU2011-27094© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY licensehttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/261602026-06-12T07:21:37Z
dc.title.none.fl_str_mv Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
title Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
spellingShingle Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
Bettinardi, Ruggero G.
Brain states
Connectivity
Anesthesia levels
Default-mode network
Alpha rhythm
Gamma rhythm
title_short Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
title_full Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
title_fullStr Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
title_full_unstemmed Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
title_sort Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
dc.creator.none.fl_str_mv Bettinardi, Ruggero G.
Tort-Colet, Núria
Ruiz Mejias, Marcel
Sanchez-Vives, Maria V.
Deco, Gustavo
author Bettinardi, Ruggero G.
author_facet Bettinardi, Ruggero G.
Tort-Colet, Núria
Ruiz Mejias, Marcel
Sanchez-Vives, Maria V.
Deco, Gustavo
author_role author
author2 Tort-Colet, Núria
Ruiz Mejias, Marcel
Sanchez-Vives, Maria V.
Deco, Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Brain states
Connectivity
Anesthesia levels
Default-mode network
Alpha rhythm
Gamma rhythm
topic Brain states
Connectivity
Anesthesia levels
Default-mode network
Alpha rhythm
Gamma rhythm
description Intrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in several neurobiological disorders. In the present study, we induced a deep state of anesthesia in rats by means of a ketamine/medetomidine peritoneal injection, and analyzed the time course of the correlation between the brain activity in different areas while anesthesia spontaneously decreased over time. We compared results separately obtained from fMRI and local field potentials (LFPs) under the same anesthesia protocol, finding that while most profound phases of anesthesia can be described by overall sparse connectivity, stereotypical activity and poor functional integration, during lighter states different frequency-specific functional networks emerge, endowing the gradual restoration of structured large-scale activity seen during rest. Noteworthy, our in vivo results show that those areas belonging to the same functional network (the default-mode) exhibited sustained correlated oscillations around 10 Hz throughout the protocol, suggesting the presence of a specific functional backbone that is preserved even during deeper phases of anesthesia. Finally, the overall pattern of results obtained from both imaging and in vivo-recordings suggests that the progressive emergence from deep anesthesia is reflected by a corresponding gradual increase of organized correlated oscillations across the cortex.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26160
http://dx.doi.org/10.1016/j.neuroimage.2015.03.037
url http://hdl.handle.net/10230/26160
http://dx.doi.org/10.1016/j.neuroimage.2015.03.037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv NeuroImage. 2015;114:185-198
info:eu-repo/grantAgreement/EC/FP7/295129
info:eu-repo/grantAgreement/EC/FP7/269921
info:eu-repo/grantAgreement/EC/FP7/269459
info:eu-repo/grantAgreement/EC/FP7/600806
info:eu-repo/grantAgreement/EC/FP7/604102
info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P
info:eu-repo/grantAgreement/ES/3PN/BFU2011-27094
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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