TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

BACKGROUND: Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. OBJECTIVE: The objective was to examine the interaction between TCF7L2 rs790314...

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Authors: Grau, K. (K.)|||/items/dee32024-fa7a-4ab1-8273-3a025e0e73fc, Cauchi, S. (Stephane)|||/items/c94d3651-a23e-4caf-88fa-1f131615b3f8, Claus, C. (C.)|||/items/f822f8af-77ff-4f87-876e-4ed404f2e216, Astrup, A. (Arne)|||/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, MacDonald, I. (Ian)|||/items/c1052005-3adc-4628-8276-f2803549627f, Klimcakova, E. (E.)|||/items/8635df1e-657c-40c4-bfe5-03821c37a170, Langin, D. (D.)|||/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81, Pedersen, O. (Oluf)|||/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7, Froguel, P. (Philippe)|||/items/9e9758d5-6b99-406b-ad31-e7eb687e1721, Sørensen, T.I.A (Thorkild I. A.)|||/items/be862a34-8bb8-4755-ac24-3ed3689e43d0
Format: article
Publication Date:2010
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/28214
Online Access:https://hdl.handle.net/10171/28214
Access Level:Open access
Keyword:Diet, reducing
Dietary carbohydrates
Dietary fats
Obesity
TCF transcription factors
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spelling TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic dietGrau, K. (K.)|||/items/dee32024-fa7a-4ab1-8273-3a025e0e73fcCauchi, S. (Stephane)|||/items/c94d3651-a23e-4caf-88fa-1f131615b3f8Claus, C. (C.)|||/items/f822f8af-77ff-4f87-876e-4ed404f2e216Astrup, A. (Arne)|||/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131MacDonald, I. (Ian)|||/items/c1052005-3adc-4628-8276-f2803549627fKlimcakova, E. (E.)|||/items/8635df1e-657c-40c4-bfe5-03821c37a170Langin, D. (D.)|||/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81Pedersen, O. (Oluf)|||/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7Froguel, P. (Philippe)|||/items/9e9758d5-6b99-406b-ad31-e7eb687e1721Sørensen, T.I.A (Thorkild I. A.)|||/items/be862a34-8bb8-4755-ac24-3ed3689e43d0Diet, reducingDietary carbohydratesDietary fatsObesityTCF transcription factorsBACKGROUND: Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. OBJECTIVE: The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals' responses to a 10-wk hypoenergetic diet (-600 kcal/d). DESIGN: European, obese participants (n = 771) were randomly assigned to receive an HF or an LF diet. Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation in percentage of REE (FatOx), homeostasis model assessed insulin release (HOMA-beta), and HOMA-insulin resistance (HOMA-IR) were determined at baseline and after the intervention; 739 individuals were genotyped for rs7903146. RESULTS: Average weight loss was 6.9 kg with the LF and 6.6 kg with the HF (difference between diets, NS) diet. Among individuals who were homozygous for the T-risk allele, those in the HF diet group experienced smaller weight losses (Deltaweight) (2.6 kg; P = 0.009; n = 622), smaller DeltaFFM (1.6 kg; P = 0.027; n = 609), smaller DeltaWC (3.3 cm; P = 0.010; n = 608), and a smaller DeltaHOMA-IR (1.3 units; P = 0.004; n = 615) than did the LF diet group. For C allele carriers, there were no differences between the HF and LF diet groups. For the HF diet group, each additional T allele was associated with a reduced loss of FM (0.67 kg; P = 0.019; n = 609). TCF7L2 rs7903146 was not associated with DeltaREE, DeltaFatOx, DeltaHOMA-beta, or dropout. CONCLUSION: Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T-risk allele are more sensitive to LF than to HF weight-loss diets.American Society for NutritionDadun. Depósito Académico Digital Universidad de Navarra20132013-04-0620102010-01-0120102010-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/28214reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/282142026-06-21T12:47:57Z
dc.title.none.fl_str_mv TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
title TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
spellingShingle TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
Grau, K. (K.)|||/items/dee32024-fa7a-4ab1-8273-3a025e0e73fc
Diet, reducing
Dietary carbohydrates
Dietary fats
Obesity
TCF transcription factors
title_short TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
title_full TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
title_fullStr TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
title_full_unstemmed TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
title_sort TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
dc.creator.none.fl_str_mv Grau, K. (K.)|||/items/dee32024-fa7a-4ab1-8273-3a025e0e73fc
Cauchi, S. (Stephane)|||/items/c94d3651-a23e-4caf-88fa-1f131615b3f8
Claus, C. (C.)|||/items/f822f8af-77ff-4f87-876e-4ed404f2e216
Astrup, A. (Arne)|||/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
MacDonald, I. (Ian)|||/items/c1052005-3adc-4628-8276-f2803549627f
Klimcakova, E. (E.)|||/items/8635df1e-657c-40c4-bfe5-03821c37a170
Langin, D. (D.)|||/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81
Pedersen, O. (Oluf)|||/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7
Froguel, P. (Philippe)|||/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
Sørensen, T.I.A (Thorkild I. A.)|||/items/be862a34-8bb8-4755-ac24-3ed3689e43d0
author Grau, K. (K.)|||/items/dee32024-fa7a-4ab1-8273-3a025e0e73fc
author_facet Grau, K. (K.)|||/items/dee32024-fa7a-4ab1-8273-3a025e0e73fc
Cauchi, S. (Stephane)|||/items/c94d3651-a23e-4caf-88fa-1f131615b3f8
Claus, C. (C.)|||/items/f822f8af-77ff-4f87-876e-4ed404f2e216
Astrup, A. (Arne)|||/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
MacDonald, I. (Ian)|||/items/c1052005-3adc-4628-8276-f2803549627f
Klimcakova, E. (E.)|||/items/8635df1e-657c-40c4-bfe5-03821c37a170
Langin, D. (D.)|||/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81
Pedersen, O. (Oluf)|||/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7
Froguel, P. (Philippe)|||/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
Sørensen, T.I.A (Thorkild I. A.)|||/items/be862a34-8bb8-4755-ac24-3ed3689e43d0
author_role author
author2 Cauchi, S. (Stephane)|||/items/c94d3651-a23e-4caf-88fa-1f131615b3f8
Claus, C. (C.)|||/items/f822f8af-77ff-4f87-876e-4ed404f2e216
Astrup, A. (Arne)|||/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
MacDonald, I. (Ian)|||/items/c1052005-3adc-4628-8276-f2803549627f
Klimcakova, E. (E.)|||/items/8635df1e-657c-40c4-bfe5-03821c37a170
Langin, D. (D.)|||/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81
Pedersen, O. (Oluf)|||/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7
Froguel, P. (Philippe)|||/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
Sørensen, T.I.A (Thorkild I. A.)|||/items/be862a34-8bb8-4755-ac24-3ed3689e43d0
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Diet, reducing
Dietary carbohydrates
Dietary fats
Obesity
TCF transcription factors
topic Diet, reducing
Dietary carbohydrates
Dietary fats
Obesity
TCF transcription factors
description BACKGROUND: Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. OBJECTIVE: The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals' responses to a 10-wk hypoenergetic diet (-600 kcal/d). DESIGN: European, obese participants (n = 771) were randomly assigned to receive an HF or an LF diet. Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation in percentage of REE (FatOx), homeostasis model assessed insulin release (HOMA-beta), and HOMA-insulin resistance (HOMA-IR) were determined at baseline and after the intervention; 739 individuals were genotyped for rs7903146. RESULTS: Average weight loss was 6.9 kg with the LF and 6.6 kg with the HF (difference between diets, NS) diet. Among individuals who were homozygous for the T-risk allele, those in the HF diet group experienced smaller weight losses (Deltaweight) (2.6 kg; P = 0.009; n = 622), smaller DeltaFFM (1.6 kg; P = 0.027; n = 609), smaller DeltaWC (3.3 cm; P = 0.010; n = 608), and a smaller DeltaHOMA-IR (1.3 units; P = 0.004; n = 615) than did the LF diet group. For C allele carriers, there were no differences between the HF and LF diet groups. For the HF diet group, each additional T allele was associated with a reduced loss of FM (0.67 kg; P = 0.019; n = 609). TCF7L2 rs7903146 was not associated with DeltaREE, DeltaFatOx, DeltaHOMA-beta, or dropout. CONCLUSION: Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T-risk allele are more sensitive to LF than to HF weight-loss diets.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01
2010
2010-01-01
2013
2013-04-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/28214
url https://hdl.handle.net/10171/28214
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Nutrition
publisher.none.fl_str_mv American Society for Nutrition
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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