Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

© The author(s).

Detalles Bibliográficos
Autores: Valent, Peter, Akin, Cem, Hartmann, Karin, Nilsson, Gunnar, Reiter, Andreas, Hermine, Olivier, Sotlar, Karl, Sperr, Wolfgang R., Escribano, Luis, George, Tracy I., Kluin-Nelemans, Hanneke C., Ustun, Celalettin, Triggiani, Massimo, Brockow, Knut, Gotlib, Jason, Orfao, Alberto, Kovanen, Petri T., Hadzijusufovic, Emir, Sadovnik, Irina, Horn, Hans-Peter, Arock, Michel, Schwartz, Lawrence B., Austen, K. Frank, Metcalfe, Dean D., Galli, Stephen J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/226498
Acceso en línea:http://hdl.handle.net/10261/226498
Access Level:acceso abierto
Palabra clave:Histamine
IgE receptor
KIT
Mast cell activation
Mastocytosis
Tryptase
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spelling Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine conceptsValent, PeterAkin, CemHartmann, KarinNilsson, GunnarReiter, AndreasHermine, OlivierSotlar, KarlSperr, Wolfgang R.Escribano, LuisGeorge, Tracy I.Kluin-Nelemans, Hanneke C.Ustun, CelalettinTriggiani, MassimoBrockow, KnutGotlib, JasonOrfao, AlbertoKovanen, Petri T.Hadzijusufovic, EmirSadovnik, IrinaHorn, Hans-PeterArock, MichelSchwartz, Lawrence B.Austen, K. FrankMetcalfe, Dean D.Galli, Stephen J.HistamineIgE receptorKITMast cell activationMastocytosisTryptase© The author(s).The origin and functions of mast cells (MCs) have been debated since their description by Paul Ehrlich in 1879. MCs have long been considered 'reactive bystanders' and 'amplifiers' in inflammatory processes, allergic reactions, and host responses to infectious diseases. However, knowledge about the origin, phenotypes and functions of MCs has increased substantially over the past 50 years. MCs are now known to be derived from multipotent hematopoietic progenitors, which, through a process of differentiation and maturation, form a unique hematopoietic lineage residing in multiple organs. In particular, MCs are distinguishable from basophils and other hematopoietic cells by their unique phenotype, origin(s), and spectrum of functions, both in innate and adaptive immune responses and in other settings. The concept of a unique MC lineage is further supported by the development of a distinct group of neoplasms, collectively referred to as mastocytosis, in which MC precursors expand as clonal cells. The clinical consequences of the expansion and/or activation of MCs are best established in mastocytosis and in allergic inflammation. However, MCs have also been implicated as important participants in a number of additional pathologic conditions and physiological processes. In this article, we review concepts regarding MC development, factors controlling MC expansion and activation, and some of the fundamental roles MCs may play in both health and disease. We also discuss new concepts for suppressing MC expansion and/or activation using molecularly-targeted drugs.P.V. was supported by the Austrian Science Fund (FWF), grants F4701-B28, F4704-B28 and P32470-B. DDM is supported by the Division of Intramural Research, NIAID. SJG's research is supported by the NIH, USA, the US-Israel Binational Foundation, and the Department of Pathology and the Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA.Ivyspring International PublisherAustrian Science FundNational Institutes of Health (US)United States-Israel Binational Science FoundationStanford UniversityConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/226498reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.7150/thno.46719Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2264982026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
title Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
spellingShingle Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
Valent, Peter
Histamine
IgE receptor
KIT
Mast cell activation
Mastocytosis
Tryptase
title_short Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
title_full Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
title_fullStr Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
title_full_unstemmed Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
title_sort Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
dc.creator.none.fl_str_mv Valent, Peter
Akin, Cem
Hartmann, Karin
Nilsson, Gunnar
Reiter, Andreas
Hermine, Olivier
Sotlar, Karl
Sperr, Wolfgang R.
Escribano, Luis
George, Tracy I.
Kluin-Nelemans, Hanneke C.
Ustun, Celalettin
Triggiani, Massimo
Brockow, Knut
Gotlib, Jason
Orfao, Alberto
Kovanen, Petri T.
Hadzijusufovic, Emir
Sadovnik, Irina
Horn, Hans-Peter
Arock, Michel
Schwartz, Lawrence B.
Austen, K. Frank
Metcalfe, Dean D.
Galli, Stephen J.
author Valent, Peter
author_facet Valent, Peter
Akin, Cem
Hartmann, Karin
Nilsson, Gunnar
Reiter, Andreas
Hermine, Olivier
Sotlar, Karl
Sperr, Wolfgang R.
Escribano, Luis
George, Tracy I.
Kluin-Nelemans, Hanneke C.
Ustun, Celalettin
Triggiani, Massimo
Brockow, Knut
Gotlib, Jason
Orfao, Alberto
Kovanen, Petri T.
Hadzijusufovic, Emir
Sadovnik, Irina
Horn, Hans-Peter
Arock, Michel
Schwartz, Lawrence B.
Austen, K. Frank
Metcalfe, Dean D.
Galli, Stephen J.
author_role author
author2 Akin, Cem
Hartmann, Karin
Nilsson, Gunnar
Reiter, Andreas
Hermine, Olivier
Sotlar, Karl
Sperr, Wolfgang R.
Escribano, Luis
George, Tracy I.
Kluin-Nelemans, Hanneke C.
Ustun, Celalettin
Triggiani, Massimo
Brockow, Knut
Gotlib, Jason
Orfao, Alberto
Kovanen, Petri T.
Hadzijusufovic, Emir
Sadovnik, Irina
Horn, Hans-Peter
Arock, Michel
Schwartz, Lawrence B.
Austen, K. Frank
Metcalfe, Dean D.
Galli, Stephen J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Austrian Science Fund
National Institutes of Health (US)
United States-Israel Binational Science Foundation
Stanford University
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Histamine
IgE receptor
KIT
Mast cell activation
Mastocytosis
Tryptase
topic Histamine
IgE receptor
KIT
Mast cell activation
Mastocytosis
Tryptase
description © The author(s).
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/226498
url http://hdl.handle.net/10261/226498
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.7150/thno.46719
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Ivyspring International Publisher
publisher.none.fl_str_mv Ivyspring International Publisher
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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