The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study

bjective: To assess the economic burden of epithelial ovarian cancer (EOC) in incident patients and the burden by disease stage in Spain. Methods: We developed a Markov model from a social perspective simulating the natural history of EOC and its four stages, with a 10-year time horizon, 3-week cycl...

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Autores: Delgado-Ortega, Laura, González-Domínguez, Almudena, Borràs Andrés, Josep Maria, Oliva-Moreno, Juan, González‑Haba, Eva, Menjón, Salomón, Pérez, Pedro, Vicente, David, Cordero, Luis, Jiménez, Margarita, Simón, Susana, Hidalgo‑Vega, Álvaro, Moya‑Alarcón, Carlota
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171990
Acceso en línea:https://hdl.handle.net/2445/171990
Access Level:acceso abierto
Palabra clave:Càncer d'ovari
Diagnòstic
Ovarian cancer
Diagnosis
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spelling The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost studyDelgado-Ortega, LauraGonzález-Domínguez, AlmudenaBorràs Andrés, Josep MariaOliva-Moreno, JuanGonzález‑Haba, EvaMenjón, SalomónPérez, PedroVicente, DavidCordero, LuisJiménez, MargaritaSimón, SusanaHidalgo‑Vega, ÁlvaroMoya‑Alarcón, CarlotaCàncer d'ovariDiagnòsticOvarian cancerDiagnosisbjective: To assess the economic burden of epithelial ovarian cancer (EOC) in incident patients and the burden by disease stage in Spain. Methods: We developed a Markov model from a social perspective simulating the natural history of EOC and its four stages, with a 10-year time horizon, 3-week cycles, 3% discount rate, and 2016 euros. Healthcare resource utilization and costs were estimated by disease stage. Direct healthcare costs (DHC) included early screening, genetic counselling, medical visits, diagnostic tests, surgery, chemotherapy, hospitalizations, emergency services, and palliative care. Direct non-healthcare costs (DNHC) included formal and informal care. Indirect costs (IC) included labour productivity losses due to temporary and permanent leaves, and premature death. Epidemiology data and resource use were taken from the literature and validated for Spain by the OvarCost group using a Delphi method. Results: The total burden of EOC over 10 years was 3102 mill euros: 15.1% in stage I, 3.9% in stage II, 41.0% in stage III, and 40.2% in stage IV. Annual average cost/patient was 24,111 and it was 8,641; 14,184; 33,858, and 42,547 in stages I-IV, respectively. Of total costs, 71.2% were due to DHC, 24.7% to DNHC, and 4.1% to IC. Conclusions: EOC imposes a significant economic burden on the national healthcare system and society in Spain. Investment in better early diagnosis techniques might increase survival and patients' quality of life. This would likely reduce costs derived from late stages, consequently leading to a substantial reduction of the economic burden associated with EOC.Springer Verlag2020202020192020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/171990Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s10198-018-0986-yEuropean Journal of Health Economics, 2019, vol. 20, num. 1, p. 135-147https://doi.org/10.1007/s10198-018-0986-ycc-by (c) Delgado-Ortega et. al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1719902026-05-29T05:05:01Z
dc.title.none.fl_str_mv The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
title The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
spellingShingle The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
Delgado-Ortega, Laura
Càncer d'ovari
Diagnòstic
Ovarian cancer
Diagnosis
title_short The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
title_full The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
title_fullStr The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
title_full_unstemmed The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
title_sort The economic burden of disease of epithelial ovarian cancer in Spain: the OvarCost study
dc.creator.none.fl_str_mv Delgado-Ortega, Laura
González-Domínguez, Almudena
Borràs Andrés, Josep Maria
Oliva-Moreno, Juan
González‑Haba, Eva
Menjón, Salomón
Pérez, Pedro
Vicente, David
Cordero, Luis
Jiménez, Margarita
Simón, Susana
Hidalgo‑Vega, Álvaro
Moya‑Alarcón, Carlota
author Delgado-Ortega, Laura
author_facet Delgado-Ortega, Laura
González-Domínguez, Almudena
Borràs Andrés, Josep Maria
Oliva-Moreno, Juan
González‑Haba, Eva
Menjón, Salomón
Pérez, Pedro
Vicente, David
Cordero, Luis
Jiménez, Margarita
Simón, Susana
Hidalgo‑Vega, Álvaro
Moya‑Alarcón, Carlota
author_role author
author2 González-Domínguez, Almudena
Borràs Andrés, Josep Maria
Oliva-Moreno, Juan
González‑Haba, Eva
Menjón, Salomón
Pérez, Pedro
Vicente, David
Cordero, Luis
Jiménez, Margarita
Simón, Susana
Hidalgo‑Vega, Álvaro
Moya‑Alarcón, Carlota
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'ovari
Diagnòstic
Ovarian cancer
Diagnosis
topic Càncer d'ovari
Diagnòstic
Ovarian cancer
Diagnosis
description bjective: To assess the economic burden of epithelial ovarian cancer (EOC) in incident patients and the burden by disease stage in Spain. Methods: We developed a Markov model from a social perspective simulating the natural history of EOC and its four stages, with a 10-year time horizon, 3-week cycles, 3% discount rate, and 2016 euros. Healthcare resource utilization and costs were estimated by disease stage. Direct healthcare costs (DHC) included early screening, genetic counselling, medical visits, diagnostic tests, surgery, chemotherapy, hospitalizations, emergency services, and palliative care. Direct non-healthcare costs (DNHC) included formal and informal care. Indirect costs (IC) included labour productivity losses due to temporary and permanent leaves, and premature death. Epidemiology data and resource use were taken from the literature and validated for Spain by the OvarCost group using a Delphi method. Results: The total burden of EOC over 10 years was 3102 mill euros: 15.1% in stage I, 3.9% in stage II, 41.0% in stage III, and 40.2% in stage IV. Annual average cost/patient was 24,111 and it was 8,641; 14,184; 33,858, and 42,547 in stages I-IV, respectively. Of total costs, 71.2% were due to DHC, 24.7% to DNHC, and 4.1% to IC. Conclusions: EOC imposes a significant economic burden on the national healthcare system and society in Spain. Investment in better early diagnosis techniques might increase survival and patients' quality of life. This would likely reduce costs derived from late stages, consequently leading to a substantial reduction of the economic burden associated with EOC.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/171990
url https://hdl.handle.net/2445/171990
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s10198-018-0986-y
European Journal of Health Economics, 2019, vol. 20, num. 1, p. 135-147
https://doi.org/10.1007/s10198-018-0986-y
dc.rights.none.fl_str_mv cc-by (c) Delgado-Ortega et. al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Delgado-Ortega et. al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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