Optimizing the radioisotope production of the novel AMIT superconducting weak focusing cyclotron
Nuclear imaging techniques are becoming one of the most widely used medical diagnostics tools for certain illness such as cancer and Alzheimer disease. The increase in these medical procedures, particularly positron emission tomography, is leading to a saturation of the actual radioisotope productio...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/11586 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/11586 |
| Access Level: | acceso abierto |
| Palabra clave: | 539.183.2(043.2) AMIT cyclotron Radioisotope production Ciclotrón AMIT Producción de radioisótopos Física nuclear 2207 Física Atómica y Nuclear |
| Sumario: | Nuclear imaging techniques are becoming one of the most widely used medical diagnostics tools for certain illness such as cancer and Alzheimer disease. The increase in these medical procedures, particularly positron emission tomography, is leading to a saturation of the actual radioisotope production system. Therefore, particle accelerators, specially the cyclotron, emerged as an alternative to the traditional supply system based on centralized production in nuclear reactors. Its characteristics from the physical and technological point of view allow a controlled and localized production, especially relevant in the case of short-lived radionuclides, through a well-known technology developed for decades without the use of a large and expensive facilities. With that in mind, the AMIT project (Advanced Molecular Imaging Technologies) aims to extend the use of these medical procedures with the development of a new compact cyclotron focused on the on-site short-life radioisotopes production, specifically 11C and 18F, in hospitals and research centers. In order to achieve this main objective, the AMIT cyclotron is based on a classical weak focus configuration with high magnetic field provided by a superconducting magnet with an autonomous cryogenic system. In addition, with the aim of reducing the total size of the accelerator, the cyclotron employs an internal H- ion source with an electron stripping system that provides a final proton beam that is transported to the production target. This thesis evaluates the challenging combination of all the technical characteristics of the AMIT cyclotron, which results in a balance of the beam dynamics with all the subsystems to achieve an optimal radioisotope production. For this goal, all the physical processes associated with the beam acceleration from the ions production and the injection into the accelerator, to the extraction of the resulting beam and its transport to the target are studied by means of theoretical analysis, computational calculations and experimental measurements... |
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