Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity
We report the characterization of a cDNA induced in mouse macrophages that encodes a 332-amino acid protein with extensive sequence identity with members of the mammalian nudC-like genes. The interaction between mNUDC and the regulatory β subunit of platelet activating factor acetylhydrolase I (PAF-...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2007 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/414193 |
| Acceso en línea: | http://hdl.handle.net/10261/414193 |
| Access Level: | acceso abierto |
| Palabra clave: | GST Glutathione-S-transferase LIS-1 lisoencephaly gene 1 NudC Nuclear distribution clone C NudF nuclear distribution clone F PAF platelet activating factor PAF-AH(I) Platelet activating factor acetylhydrolase type I Monocytes/macrophages Inflammation Platelet activating factor acetylhydrolase nudC |
| Sumario: | We report the characterization of a cDNA induced in mouse macrophages that encodes a 332-amino acid protein with extensive sequence identity with members of the mammalian nudC-like genes. The interaction between mNUDC and the regulatory β subunit of platelet activating factor acetylhydrolase I (PAF-AH(I)) shown in this article indicates a new function of NUDC. Thus, we show that NUDC increases the catalytic activity of PAF-AH(I) and that this regulatory activity is located in the carboxyl terminal half of the protein which is highly conserved. This suggests a novel function for mammalian nudC-like genes as anti-inflammatory proteins. |
|---|