Motility and morphodynamics of confined cells

We introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biologicalcell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an activecytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous d...

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Detalles Bibliográficos
Autores: Lavi, Ido, Meunier, Nicolas, Voituriez, Raphaël, Casademunt i Viader, Jaume
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/159357
Acceso en línea:https://hdl.handle.net/2445/159357
Access Level:acceso abierto
Palabra clave:Cèl·lules
Dinàmica molecular
Dinàmica de fluids
Cells
Molecular dynamics
Fluid dynamics
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spelling Motility and morphodynamics of confined cellsLavi, IdoMeunier, NicolasVoituriez, RaphaëlCasademunt i Viader, JaumeCèl·lulesDinàmica molecularDinàmica de fluidsCellsMolecular dynamicsFluid dynamicsWe introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biologicalcell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an activecytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous droplet in the Darcyflow regime, contains a diffusive solute that actively transduces the applied cytoskeleton force. While fairlysimple and analytically tractable, this quasi-two-dimensional model predicts a range of compelling dynamicbehaviours. A linear stability analysis of the system reveals that solute activity first destabilizes a globalpolarization-translation mode, prompting cell motility through spontaneous symmetry breaking. At higheractivity, the system crosses a series of Hopf bifurcations leading to coupled oscillations of droplet shape andsolute concentration profiles. At the nonlinear level, we find traveling-wave solutions associated with uniquepolarized shapes that resemble experimental observations. Altogether, this model offers an analytical paradigmof active deformable systems in which viscous hydrodynamics are coupled to diffusive force transducers.American Physical Society2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion20 p.application/pdfhttps://hdl.handle.net/2445/159357Articles publicats en revistes (Física de la Matèria Condensada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1103/PhysRevE.101.022404Physical Review E, 2020, vol. 101, num. 2, p. 022404https://doi.org/10.1103/PhysRevE.101.022404(c) American Physical Society, 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1593572026-05-29T05:05:01Z
dc.title.none.fl_str_mv Motility and morphodynamics of confined cells
title Motility and morphodynamics of confined cells
spellingShingle Motility and morphodynamics of confined cells
Lavi, Ido
Cèl·lules
Dinàmica molecular
Dinàmica de fluids
Cells
Molecular dynamics
Fluid dynamics
title_short Motility and morphodynamics of confined cells
title_full Motility and morphodynamics of confined cells
title_fullStr Motility and morphodynamics of confined cells
title_full_unstemmed Motility and morphodynamics of confined cells
title_sort Motility and morphodynamics of confined cells
dc.creator.none.fl_str_mv Lavi, Ido
Meunier, Nicolas
Voituriez, Raphaël
Casademunt i Viader, Jaume
author Lavi, Ido
author_facet Lavi, Ido
Meunier, Nicolas
Voituriez, Raphaël
Casademunt i Viader, Jaume
author_role author
author2 Meunier, Nicolas
Voituriez, Raphaël
Casademunt i Viader, Jaume
author2_role author
author
author
dc.subject.none.fl_str_mv Cèl·lules
Dinàmica molecular
Dinàmica de fluids
Cells
Molecular dynamics
Fluid dynamics
topic Cèl·lules
Dinàmica molecular
Dinàmica de fluids
Cells
Molecular dynamics
Fluid dynamics
description We introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biologicalcell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an activecytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous droplet in the Darcyflow regime, contains a diffusive solute that actively transduces the applied cytoskeleton force. While fairlysimple and analytically tractable, this quasi-two-dimensional model predicts a range of compelling dynamicbehaviours. A linear stability analysis of the system reveals that solute activity first destabilizes a globalpolarization-translation mode, prompting cell motility through spontaneous symmetry breaking. At higheractivity, the system crosses a series of Hopf bifurcations leading to coupled oscillations of droplet shape andsolute concentration profiles. At the nonlinear level, we find traveling-wave solutions associated with uniquepolarized shapes that resemble experimental observations. Altogether, this model offers an analytical paradigmof active deformable systems in which viscous hydrodynamics are coupled to diffusive force transducers.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/159357
url https://hdl.handle.net/2445/159357
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1103/PhysRevE.101.022404
Physical Review E, 2020, vol. 101, num. 2, p. 022404
https://doi.org/10.1103/PhysRevE.101.022404
dc.rights.none.fl_str_mv (c) American Physical Society, 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Physical Society, 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20 p.
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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