the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)

Molina Jaramillo, Elda; Espinel, Elithsine; Borja, Dayana; Santamaria, Javier; Reyes, Carmita; Grijalva, Jorge; Vera, Roy

the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)

The increase in neurodegenerative diseases has led to the search for products with nootropic activity as adjuvants for the prevention or treatment of these pathologies. In this study, we aim to evaluate the nootropic activity of the extract coffee pulp (Coffea arabica) in small mammals. In the first...

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Autores:	Molina Jaramillo, Elda, Espinel, Elithsine, Borja, Dayana, Santamaria, Javier, Reyes, Carmita, Grijalva, Jorge, Vera, Roy
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	Ecuador
Institución:	Universidad Central del Ecuador
Repositorio:	Revista Química central
Idioma:	español
OAI Identifier:	oai:revistadigital.uce.edu.ec:article/3332
Acceso en línea:	https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332
Access Level:	acceso abierto
Palabra clave:	Ácido clorogénico actividad nootrópica aprendizaje memoria Chlorogenic acid Nootropic activity Learning Memory

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network_acronym_str	EC
network_name_str	Ecuador
repository_id_str
dc.title.none.fl_str_mv	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica) La Evaluación de la actividad nootrópica del ácido clorogénico presente en el café para el tratamiento preventivo de enfermedades neurodegenerativas: Actividad Nootrópica del Extracto de la pulpa de café (Coffea arabica)
title	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)
spellingShingle	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica) Molina Jaramillo, Elda Ácido clorogénico actividad nootrópica aprendizaje memoria Chlorogenic acid Nootropic activity Learning Memory
title_short	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)
title_full	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)
title_fullStr	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)
title_full_unstemmed	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)
title_sort	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)
dc.creator.none.fl_str_mv	Molina Jaramillo, Elda Espinel, Elithsine Borja, Dayana Santamaria, Javier Reyes, Carmita Grijalva, Jorge Vera, Roy
author	Molina Jaramillo, Elda
author_facet	Molina Jaramillo, Elda Espinel, Elithsine Borja, Dayana Santamaria, Javier Reyes, Carmita Grijalva, Jorge Vera, Roy
author_role	author
author2	Espinel, Elithsine Borja, Dayana Santamaria, Javier Reyes, Carmita Grijalva, Jorge Vera, Roy
author2_role	author author author author author author
dc.subject.none.fl_str_mv	Ácido clorogénico actividad nootrópica aprendizaje memoria Chlorogenic acid Nootropic activity Learning Memory
topic	Ácido clorogénico actividad nootrópica aprendizaje memoria Chlorogenic acid Nootropic activity Learning Memory
description	The increase in neurodegenerative diseases has led to the search for products with nootropic activity as adjuvants for the prevention or treatment of these pathologies. In this study, we aim to evaluate the nootropic activity of the extract coffee pulp (Coffea arabica) in small mammals. In the first phase, total phenols were quantified from the coffee samples with the Folin-Ciocalteu method by using both dynamic and assisted maceration. Data were analyzed using ANOVA and Duncan's post-hoc test. In the second phase, twenty-four mice (Mus musculus) of 32.5 g on average were used. These animals were split up into four groups and assigned to one of the following treatments: water as negative control, Ginkgo Biloba as positive control, and two doses of coffee pulp extract. The mice were subjected to training and learning tests in the eight-arm-radial and Morris’s aquatic labyrinth. The latency-time and time that each mouse takes to visit the eight arms of the labyrinth were recorded. The extract of arabica coffee pulp reflects nootropic activity, whose dose 100 mg/kg of weight/day of chlorogenic acid (ACG) contributes to the improvement of cognitive properties.
publishDate	2021
dc.date.none.fl_str_mv	2021-12-31
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332 10.29166/quimica.v7i2.3332
url	https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332
identifier_str_mv	10.29166/quimica.v7i2.3332
dc.language.none.fl_str_mv	spa
language	spa
dc.relation.none.fl_str_mv	https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332/4597 https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332/4598 https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332/4599
dc.rights.none.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf text/html
dc.publisher.none.fl_str_mv	Universidad Central del Ecuador
publisher.none.fl_str_mv	Universidad Central del Ecuador
dc.source.none.fl_str_mv	Química Central; Vol. 7 Núm. 2 (2021): Química Central; 32-39 2477-9121 1390-5562 10.29166/quimica.v7i2 reponame:Revista Química central instname:Universidad Central del Ecuador instacron:UCE
instname_str	Universidad Central del Ecuador
instacron_str	UCE
institution	UCE
reponame_str	Revista Química central
collection	Revista Química central
repository.name.fl_str_mv	Revista Química central - Universidad Central del Ecuador
repository.mail.fl_str_mv	.
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spelling	the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)La Evaluación de la actividad nootrópica del ácido clorogénico presente en el café para el tratamiento preventivo de enfermedades neurodegenerativas: Actividad Nootrópica del Extracto de la pulpa de café (Coffea arabica) Molina Jaramillo, EldaEspinel, Elithsine Borja, Dayana Santamaria, JavierReyes, CarmitaGrijalva, JorgeVera, RoyÁcido clorogénico actividad nootrópicaaprendizaje memoriaChlorogenic acidNootropic activityLearning MemoryThe increase in neurodegenerative diseases has led to the search for products with nootropic activity as adjuvants for the prevention or treatment of these pathologies. In this study, we aim to evaluate the nootropic activity of the extract coffee pulp (Coffea arabica) in small mammals. In the first phase, total phenols were quantified from the coffee samples with the Folin-Ciocalteu method by using both dynamic and assisted maceration. Data were analyzed using ANOVA and Duncan's post-hoc test. In the second phase, twenty-four mice (Mus musculus) of 32.5 g on average were used. These animals were split up into four groups and assigned to one of the following treatments: water as negative control, Ginkgo Biloba as positive control, and two doses of coffee pulp extract. The mice were subjected to training and learning tests in the eight-arm-radial and Morris’s aquatic labyrinth. The latency-time and time that each mouse takes to visit the eight arms of the labyrinth were recorded. The extract of arabica coffee pulp reflects nootropic activity, whose dose 100 mg/kg of weight/day of chlorogenic acid (ACG) contributes to the improvement of cognitive properties.El aumento de enfermedades neurodegenerativas ha conducido a la búsqueda de productos con actividad nootrópica para la prevención o tratamiento de esas patologías. En este estudio buscamos evaluar la actividad nootrópica del extracto de la pulpa del café arábica (Coffea arabica) en mamíferos menores. En la primera fase se cuantificaron los fenoles totales en la pulpa de café mediante el método Folin Ciocalteu extraídos con maceración dinámica y asistida. Los datos se analizaron mediante adeva y la prueba posthoc de Duncan. En la segunda fase se utilizaron 24 ratones (Mus musculus) de 32,5 g de peso promedio.Los ratones fueron divididos en cuatro grupos y asignados a los siguientes tratamientos: agua (control negativo), ginkgo biloba (control positivo) y dos dosis de extracto de pulpa de café. Los ratones se sometieron a pruebas de aprendizaje en el laberinto acuático de Morris y el laberinto radial de 8 brazos. Se registró el tiempo de latencia y el tiempo que demoraron los ratones en visitar los 8 brazos del laberinto. El extracto de la pulpa de café arábica refleja actividad nootrópica, cuya dosis 100 mg/kg de peso/día de ácido clorogénico (acg) contribuye al mejoramiento de las propiedades cognitivas.Universidad Central del Ecuador2021-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdftext/htmlhttps://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/333210.29166/quimica.v7i2.3332Química Central; Vol. 7 Núm. 2 (2021): Química Central; 32-392477-91211390-556210.29166/quimica.v7i2reponame:Revista Química centralinstname:Universidad Central del Ecuadorinstacron:UCEspahttps://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332/4597https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332/4598https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/3332/4599Derechos de autor 2022 Elda Molina Jaramillo, Elithsine Espinel, Dayana Borja, Javier Santamaria, Carmita Reyes, Jorge Grijalva, Roy Verahttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccess2022-03-30T19:57:35Zoai:revistadigital.uce.edu.ec:article/3332Portal de revistashttps://revistadigital.uce.edu.ec/Universidad públicahttps://uce.edu.ec/..Ecuador.2477-91211390-5562opendoar:02024-03-31T15:57:56.074720Revista Química central - Universidad Central del Ecuadortrue
score	15,301603

the Evaluation of the nootropic activity of the chlorogenic acid present in coffee for the preventive treatment of neurodegenerative diseases: Nootropic Activity of Coffee Pulp Extract (Coffea arabica)

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