Neurocysticercosis: Neurology and neurobiology

Neurocysticercosis, the most common parasitic brain disease worldwide, is due to the larvae infestation of Taenia solium. It is an endemic, neglected disease in poor countries with deprived sanitation, and is increasingly being reported in wealthy countries due to migration. Humans are the only defi...

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Autor: Carpio Rodas, Luis Arturo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Ecuador
Institución:Universidad de Cuenca
Repositorio:Repositorio Universidad de Cuenca
OAI Identifier:oai:dspace.ucuenca.edu.ec:123456789/29094
Acceso en línea:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84
http://dspace.ucuenca.edu.ec/handle/123456789/29094
Access Level:acceso abierto
Palabra clave:Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
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spelling Neurocysticercosis: Neurology and neurobiologyCarpio Rodas, Luis ArturoAlbendazoleEpilepsyImagingParasitic InfectionPraziquantelSeizuresTaenia SoliumTaeniasis/CysticercosisNeurocysticercosis, the most common parasitic brain disease worldwide, is due to the larvae infestation of Taenia solium. It is an endemic, neglected disease in poor countries with deprived sanitation, and is increasingly being reported in wealthy countries due to migration. Humans are the only definitive host of T. solium, while pigs are the intermediate hosts. Humans may become intermediate host by ingesting food or water contaminated by T. solium eggs.Infection is associated with local and systemic immune-inflammatory responses modulated by the developmental stage of the parasite in the host (vesicular, colloidal. granular-nodular, and calcified stages) and by the central nervous system compartment where the parasites are located. Genetic diversity of cysticerci has been studied and the genome of T. solium is currently being sequenced.The clinical manifestations are heterogeneous and depend mainly on the localization of cysts and immune response to the host. Seizures, headache, focal deficits and cognitive abnormalities are the most frequent manifestations. The prognosis is good; nevertheless, it may lead to long-term neurological sequels such as epilepsy and hydrocephalus.Diagnosis is made mainly by neuroimaging, which is useful in the detection of evolutionary stage, number and localization of cysts. Immunological testing can be helpful; nonetheless, a negative test does not rule out the diagnosis. Treatment is complex and should be individualized, based on location and viability of the parasites. In most cases treatment is only symptomatic. Antihelminthic drugs are effective in approximately one-third of patients with parenchymal viable cysts. The most effective approach to Taeniasis/cysticercosis is prevention. This should be a primary public health focus for poor countries.SPRINGER NEW YORK2018-01-11T16:47:23Z2018-01-11T16:47:23Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf9781461481003; 9781461480990https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84http://dspace.ucuenca.edu.ec/handle/123456789/2909410.1007/978-1-4614-8100-3_7Neglected Tropical Diseases and Conditions of the Nervous Systemreponame:Repositorio Universidad de Cuencainstname:Universidad de Cuencainstacron:UCUENCAen_USinfo:eu-repo/semantics/openAccess2020-08-01T01:14:56Zoai:dspace.ucuenca.edu.ec:123456789/29094Institucionalhttp://dspace.ucuenca.edu.ec/Universidad públicahttps://www.ucuenca.edu.ec/http://dspace.ucuenca.edu.ec/oai.Ecuador...opendoar:41862020-08-01T01:14:56Repositorio Universidad de Cuenca - Universidad de Cuencafalse
dc.title.none.fl_str_mv Neurocysticercosis: Neurology and neurobiology
title Neurocysticercosis: Neurology and neurobiology
spellingShingle Neurocysticercosis: Neurology and neurobiology
Carpio Rodas, Luis Arturo
Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
title_short Neurocysticercosis: Neurology and neurobiology
title_full Neurocysticercosis: Neurology and neurobiology
title_fullStr Neurocysticercosis: Neurology and neurobiology
title_full_unstemmed Neurocysticercosis: Neurology and neurobiology
title_sort Neurocysticercosis: Neurology and neurobiology
dc.creator.none.fl_str_mv Carpio Rodas, Luis Arturo
author Carpio Rodas, Luis Arturo
author_facet Carpio Rodas, Luis Arturo
author_role author
dc.subject.none.fl_str_mv Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
topic Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
description Neurocysticercosis, the most common parasitic brain disease worldwide, is due to the larvae infestation of Taenia solium. It is an endemic, neglected disease in poor countries with deprived sanitation, and is increasingly being reported in wealthy countries due to migration. Humans are the only definitive host of T. solium, while pigs are the intermediate hosts. Humans may become intermediate host by ingesting food or water contaminated by T. solium eggs.Infection is associated with local and systemic immune-inflammatory responses modulated by the developmental stage of the parasite in the host (vesicular, colloidal. granular-nodular, and calcified stages) and by the central nervous system compartment where the parasites are located. Genetic diversity of cysticerci has been studied and the genome of T. solium is currently being sequenced.The clinical manifestations are heterogeneous and depend mainly on the localization of cysts and immune response to the host. Seizures, headache, focal deficits and cognitive abnormalities are the most frequent manifestations. The prognosis is good; nevertheless, it may lead to long-term neurological sequels such as epilepsy and hydrocephalus.Diagnosis is made mainly by neuroimaging, which is useful in the detection of evolutionary stage, number and localization of cysts. Immunological testing can be helpful; nonetheless, a negative test does not rule out the diagnosis. Treatment is complex and should be individualized, based on location and viability of the parasites. In most cases treatment is only symptomatic. Antihelminthic drugs are effective in approximately one-third of patients with parenchymal viable cysts. The most effective approach to Taeniasis/cysticercosis is prevention. This should be a primary public health focus for poor countries.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
2018-01-11T16:47:23Z
2018-01-11T16:47:23Z
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 9781461481003; 9781461480990
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84
http://dspace.ucuenca.edu.ec/handle/123456789/29094
10.1007/978-1-4614-8100-3_7
identifier_str_mv 9781461481003; 9781461480990
10.1007/978-1-4614-8100-3_7
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84
http://dspace.ucuenca.edu.ec/handle/123456789/29094
dc.language.none.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SPRINGER NEW YORK
publisher.none.fl_str_mv SPRINGER NEW YORK
dc.source.none.fl_str_mv Neglected Tropical Diseases and Conditions of the Nervous System
reponame:Repositorio Universidad de Cuenca
instname:Universidad de Cuenca
instacron:UCUENCA
instname_str Universidad de Cuenca
instacron_str UCUENCA
institution UCUENCA
reponame_str Repositorio Universidad de Cuenca
collection Repositorio Universidad de Cuenca
repository.name.fl_str_mv Repositorio Universidad de Cuenca - Universidad de Cuenca
repository.mail.fl_str_mv .
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