Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?

Neurocysticercosis (NC) or infection of the central nervous system with Taenia solium larvae is a leading cause of preventable seizures and epilepsy in endemic regions across the globe. Albendazole and praziquantel are commonly used antihelminthic agents to treat NC; however, viable cysts persist in...

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Autor: Carpio Rodas, Luis Arturo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Ecuador
Institución:Universidad de Cuenca
Repositorio:Repositorio Universidad de Cuenca
OAI Identifier:oai:dspace.ucuenca.edu.ec:123456789/29145
Acceso en línea:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896119541&doi=10.1002%2fjcph.269&partnerID=40&md5=847a62340f7ca54981fbccf88e639b30
http://dspace.ucuenca.edu.ec/handle/123456789/29145
Access Level:acceso abierto
Palabra clave:Cysticercosis
Epilepsy
Parasite
Pharmacokinetics
Taenia Solium
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spelling Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?Carpio Rodas, Luis ArturoCysticercosisEpilepsyParasitePharmacokineticsTaenia SoliumNeurocysticercosis (NC) or infection of the central nervous system with Taenia solium larvae is a leading cause of preventable seizures and epilepsy in endemic regions across the globe. Albendazole and praziquantel are commonly used antihelminthic agents to treat NC; however, viable cysts persist in the majority of patients, putting them at risk for future seizures and other neurological complications. Because of their pharmacokinetic profiles, albendazole and praziquantel have the potential to interact with many different drugs. During antihelminthic treatment, antiepileptic drugs and corticosteroids are commonly co-administered to manage seizures and cerebral edema; however, the most commonly used agents from these drug classes are known to significantly alter plasma concentrations of albendazole and praziquantel. The overarching issue with drug interactions during the treatment of NC is whether or not they have clinical relevance, as the plasma concentrations of albendazole and praziquantel have not been directly linked with eradication of viable cysts. Future studies should attempt to evaluate the validity of a causal relationship between antihelminthic plasma concentrations and outcomes so that drug interactions can be better understood and managed and so that treatment can be optimized. © 2014, The American College of Clinical Pharmacology.SAGE PUBLICATIONS INC.2018-01-11T16:47:32Z2018-01-11T16:47:32Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf912700https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896119541&doi=10.1002%2fjcph.269&partnerID=40&md5=847a62340f7ca54981fbccf88e639b30http://dspace.ucuenca.edu.ec/handle/123456789/2914510.1002/jcph.269Journal of Clinical Pharmacologyreponame:Repositorio Universidad de Cuencainstname:Universidad de Cuencainstacron:UCUENCAen_USinfo:eu-repo/semantics/openAccess2020-08-01T01:15:20Zoai:dspace.ucuenca.edu.ec:123456789/29145Institucionalhttp://dspace.ucuenca.edu.ec/Universidad públicahttps://www.ucuenca.edu.ec/http://dspace.ucuenca.edu.ec/oai.Ecuador...opendoar:41862020-08-01T01:15:20Repositorio Universidad de Cuenca - Universidad de Cuencafalse
dc.title.none.fl_str_mv Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
title Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
spellingShingle Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
Carpio Rodas, Luis Arturo
Cysticercosis
Epilepsy
Parasite
Pharmacokinetics
Taenia Solium
title_short Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
title_full Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
title_fullStr Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
title_full_unstemmed Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
title_sort Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: A reason for the variable efficacy of albendazole and praziquantel?
dc.creator.none.fl_str_mv Carpio Rodas, Luis Arturo
author Carpio Rodas, Luis Arturo
author_facet Carpio Rodas, Luis Arturo
author_role author
dc.subject.none.fl_str_mv Cysticercosis
Epilepsy
Parasite
Pharmacokinetics
Taenia Solium
topic Cysticercosis
Epilepsy
Parasite
Pharmacokinetics
Taenia Solium
description Neurocysticercosis (NC) or infection of the central nervous system with Taenia solium larvae is a leading cause of preventable seizures and epilepsy in endemic regions across the globe. Albendazole and praziquantel are commonly used antihelminthic agents to treat NC; however, viable cysts persist in the majority of patients, putting them at risk for future seizures and other neurological complications. Because of their pharmacokinetic profiles, albendazole and praziquantel have the potential to interact with many different drugs. During antihelminthic treatment, antiepileptic drugs and corticosteroids are commonly co-administered to manage seizures and cerebral edema; however, the most commonly used agents from these drug classes are known to significantly alter plasma concentrations of albendazole and praziquantel. The overarching issue with drug interactions during the treatment of NC is whether or not they have clinical relevance, as the plasma concentrations of albendazole and praziquantel have not been directly linked with eradication of viable cysts. Future studies should attempt to evaluate the validity of a causal relationship between antihelminthic plasma concentrations and outcomes so that drug interactions can be better understood and managed and so that treatment can be optimized. © 2014, The American College of Clinical Pharmacology.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
2018-01-11T16:47:32Z
2018-01-11T16:47:32Z
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 912700
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896119541&doi=10.1002%2fjcph.269&partnerID=40&md5=847a62340f7ca54981fbccf88e639b30
http://dspace.ucuenca.edu.ec/handle/123456789/29145
10.1002/jcph.269
identifier_str_mv 912700
10.1002/jcph.269
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896119541&doi=10.1002%2fjcph.269&partnerID=40&md5=847a62340f7ca54981fbccf88e639b30
http://dspace.ucuenca.edu.ec/handle/123456789/29145
dc.language.none.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS INC.
publisher.none.fl_str_mv SAGE PUBLICATIONS INC.
dc.source.none.fl_str_mv Journal of Clinical Pharmacology
reponame:Repositorio Universidad de Cuenca
instname:Universidad de Cuenca
instacron:UCUENCA
instname_str Universidad de Cuenca
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repository.name.fl_str_mv Repositorio Universidad de Cuenca - Universidad de Cuenca
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